DegronMD

Uniprot ID: O43155

Source protein: Leucine-rich repeat transmembrane protein FLRT2

Source gene: FLRT2

Class: DEG_SCF_FBW7_1

Location: 397:403

E3 ligase: FBXW7

DEGRON score: 0.9719

ASA_SCORE: 81.8143

COIL: 0.9397

CONS_SCORE: 0.576

DSS_SCORE: 0.6701

HELIX: 0.0133

FCONS_SCORE: 0.9832

RIG_SCORE: 0.5985

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W411R	TCGA-55-8511	LUAD	TCGA	PPTPTTS	DEG_SCF_FBW7_1	0.1111
p.W411R	DO24940	LUAD	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.1111
p.W411L	TCGA-55-8511	LUAD	TCGA	PPTPTTS	DEG_SCF_FBW7_1	0.1111
p.W411L	DO24940	LUAD	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.1111
p.P398L	TCGA-AA-A01P	COAD	TCGA	PPTPTTS	DEG_SCF_FBW7_1	0.6471
p.P398L	DO8642	COAD	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.6471
p.S403L	TCGA-B5-A0JY	UCEC	TCGA	PPTPTTS	DEG_SCF_FBW7_1	0.7667
p.S403L	TCGA-E6-A1LX	UCEC	TCGA	PPTPTTS	DEG_SCF_FBW7_1	0.7667
p.S403L	DO233147	GACA	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.7667
p.S403L	DO41020	UCEC	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.7667
p.S403L	DO43041	UCEC	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.7667
p.S392N	TCGA-B5-A1MX	UCEC	TCGA	PPTPTTS	DEG_SCF_FBW7_1	0.1944
p.S392N	DO41999	UCEC	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.1944
p.S392N	SIDM00293	Small Cell Lung Carcinoma	GDSC	PPTPTTS	DEG_SCF_FBW7_1	0.1944
p.S392N	ACH-002052	Lung Cancer	CCLE	PPTPTTS	DEG_SCF_FBW7_1	0.1944
p.S392N	LU-139	lung	COSMIC	PPTPTTS	DEG_SCF_FBW7_1	0.1944
p.R393I	TCGA-B5-A3FC	UCEC	TCGA	PPTPTTS	DEG_SCF_FBW7_1	0.2222
p.R393I	DO41871	UCEC	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.2222
p.G413D	TCGA-D7-5578	STAD	TCGA	PPTPTTS	DEG_SCF_FBW7_1	0.0556
p.G413D	DO38475	STAD	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.0556
p.T399I	TCGA-D9-A6EC	SKCM	TCGA	PPTPTTS	DEG_SCF_FBW7_1	0.7078
p.T399I	DO50291	SKCM	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.7078
p.S394N	TCGA-GN-A269	SKCM	TCGA	PPTPTTS	DEG_SCF_FBW7_1	0.25
p.S394N	DO37483	SKCM	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.25
p.D412G	TCGA-JX-A3Q0	CESC	TCGA	PPTPTTS	DEG_SCF_FBW7_1	0.0833
p.D412G	DO51607	CESC	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.0833
p.D410G	TCGA-UB-A7MB	LIHC	TCGA	PPTPTTS	DEG_SCF_FBW7_1	0.1389
p.D410G	DO52318	LIHC	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.1389
p.P400A	DO222705	ESCA	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.7503
p.T407M	DO233867	GACA	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.2222
p.N390S	DO44744	LICA	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.1389
p.D410Y	DO45089	LINC	ICGC	PPTPTTS	DEG_SCF_FBW7_1	0.1389
p.T396M	SIDM00214	Colorectal Carcinoma	GDSC	PPTPTTS	DEG_SCF_FBW7_1	0.3056
p.T396M	ACH-000955	Colon/Colorectal Cancer	CCLE	PPTPTTS	DEG_SCF_FBW7_1	0.3056
p.T396M	SNU-407	large_intestine	COSMIC	PPTPTTS	DEG_SCF_FBW7_1	0.3056
p.T401I	SIDM00150	Colorectal Carcinoma	GDSC	PPTPTTS	DEG_SCF_FBW7_1	0.5966
p.T401I	ACH-000969	Colon/Colorectal Cancer	CCLE	PPTPTTS	DEG_SCF_FBW7_1	0.5966
p.T401I	KM12	large_intestine	COSMIC	PPTPTTS	DEG_SCF_FBW7_1	0.5966

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15054	Lysine-specific demethylase 6B	DEG_SCF_FBW7_1	546:552	PPTPTTS	FBXW7	0.9817	More...
O43155	Leucine-rich repeat transmembrane protein FLRT2	DEG_SCF_FBW7_1	397:403	PPTPTTS	FBXW7	0.9719	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTPTTS

Degron related mutations and impact score

Drug responses associated with FLRT2 mutations

All proteins holding degron of PPTPTTS