DegronMD - O43155(FLRT2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W411R	TCGA-55-8511	LUAD	TCGA	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.1111
p.W411R	TCGA-55-8511	LUAD	TCGA	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.1667
p.W411R	DO24940	LUAD	ICGC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.1111
p.W411R	DO24940	LUAD	ICGC	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.1667
p.W411L	TCGA-55-8511	LUAD	TCGA	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.1111
p.W411L	TCGA-55-8511	LUAD	TCGA	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.1667
p.W411L	DO24940	LUAD	ICGC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.1111
p.W411L	DO24940	LUAD	ICGC	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.1667
p.P365L	TCGA-A5-A0G1	UCEC	TCGA	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.25
p.P365L	DO42472	UCEC	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.25
p.P398L	TCGA-AA-A01P	COAD	TCGA	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation altering degron motif	0.6471
p.P398L	DO8642	COAD	ICGC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation altering degron motif	0.6471
p.S403L	TCGA-B5-A0JY	UCEC	TCGA	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation altering degron motif	0.7667
p.S403L	TCGA-E6-A1LX	UCEC	TCGA	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation altering degron motif	0.7667
p.S403L	DO233147	GACA	ICGC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation altering degron motif	0.7667
p.S403L	DO41020	UCEC	ICGC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation altering degron motif	0.7667
p.S403L	DO43041	UCEC	ICGC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation altering degron motif	0.7667
p.S392N	TCGA-B5-A1MX	UCEC	TCGA	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.1944
p.S392N	DO41999	UCEC	ICGC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.1944
p.S392N	SIDM00293	Small Cell Lung Carcinoma	GDSC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.1944
p.S392N	ACH-002052	Lung Cancer	CCLE	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.1944
p.S392N	LU-139	lung	COSMIC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.1944
p.R393I	TCGA-B5-A3FC	UCEC	TCGA	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.2222
p.R393I	DO41871	UCEC	ICGC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.2222
p.R424W	TCGA-B6-A40C	BRCA	TCGA	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.2778
p.R424W	DO50045	BRCA	ICGC	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.2778
p.R424W	DO50946	LICA	ICGC	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.2778
p.R424W	DO51475	PACA	ICGC	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.2778
p.R424W	SIDM02013	Colorectal Carcinoma	GDSC	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.2778
p.L369R	TCGA-CD-5798	STAD	TCGA	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation altering degron motif	0.7316
p.L369R	DO234191	ESAD	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation altering degron motif	0.7316
p.L369R	DO38751	STAD	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation altering degron motif	0.7316
p.S359F	TCGA-D3-A8GI	SKCM	TCGA	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.0833
p.S359F	DO50284	SKCM	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.0833
p.G413D	TCGA-D7-5578	STAD	TCGA	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.0556
p.G413D	TCGA-D7-5578	STAD	TCGA	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.2222
p.G413D	DO38475	STAD	ICGC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.0556
p.G413D	DO38475	STAD	ICGC	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.2222
p.T399I	TCGA-D9-A6EC	SKCM	TCGA	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation altering degron motif	0.7078
p.T399I	DO50291	SKCM	ICGC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation altering degron motif	0.7078
p.P379L	TCGA-DC-6155	READ	TCGA	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.2222
p.P379L	DO36953	READ	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.2222
p.P361S	TCGA-FS-A1ZZ	SKCM	TCGA	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.1389
p.P361S	TCGA-Z2-AA3S	SKCM	TCGA	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.1389
p.P361S	DO233830	GACA	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.1389
p.P361S	DO37412	SKCM	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.1389
p.P361S	DO51302	SKCM	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.1389
p.S394N	TCGA-GN-A269	SKCM	TCGA	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.25
p.S394N	DO37483	SKCM	ICGC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.25
p.S422F	TCGA-GN-A8LK	SKCM	TCGA	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation altering degron motif	0.9093
p.S422F	DO51259	SKCM	ICGC	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation altering degron motif	0.9093
p.D412G	TCGA-JX-A3Q0	CESC	TCGA	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.0833
p.D412G	TCGA-JX-A3Q0	CESC	TCGA	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.1944
p.D412G	DO51607	CESC	ICGC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.0833
p.D412G	DO51607	CESC	ICGC	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.1944
p.D410G	TCGA-UB-A7MB	LIHC	TCGA	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.1389
p.D410G	TCGA-UB-A7MB	LIHC	TCGA	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.1389
p.D410G	DO52318	LIHC	ICGC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.1389
p.D410G	DO52318	LIHC	ICGC	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.1389
p.R424Q	TCGA-W3-AA1V	SKCM	TCGA	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.2778
p.R424Q	DO51276	SKCM	ICGC	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.2778
p.P384S	TCGA-WE-A8K1	SKCM	TCGA	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.0833
p.P384S	DO51280	SKCM	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.0833
p.Q426P	TCGA-XF-A8HG	BLCA	TCGA	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.2222
p.Q426P	DO49802	BLCA	ICGC	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.2222
p.P361L	TCGA-YD-A89C	SKCM	TCGA	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.1389
p.P361L	DO219501	SKCM	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.1389
p.P361L	SIDM01175	Other Sarcomas	GDSC	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.1389
p.P361L	ACH-001982	Metastasis	CCLE	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.1389
p.P361L	ACH-002309	Sarcoma	CCLE	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.1389
p.P361L	SW684	soft tissue	COSMIC	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.1389
p.G366S	DO48381	BLCA	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.2778
p.T380S	DO6436	CLLE	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.1944
p.S375G	DO234449	ESAD	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation altering degron motif	0.6993
p.S375G	DO234462	ESAD	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation altering degron motif	0.6993
p.S375G	DO233145	GACA	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation altering degron motif	0.6993
p.P420R	DO234464	ESAD	ICGC	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation altering degron motif	0.6401
p.P400A	DO222705	ESCA	ICGC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation altering degron motif	0.7503
p.T407M	DO233867	GACA	ICGC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.2222
p.T407M	DO233867	GACA	ICGC	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.0556
p.T376A	DO233903	GACA	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.3056
p.N390S	DO44744	LICA	ICGC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.1389
p.D410Y	DO45089	LINC	ICGC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.1389
p.D410Y	DO45089	LINC	ICGC	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.1389
p.R414K	DO45096	LIRI	ICGC	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.25
p.P374S	DO35083	PACA	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation altering degron motif	0.5641
p.T396M	SIDM00214	Colorectal Carcinoma	GDSC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.3056
p.T396M	ACH-000955	Colon/Colorectal Cancer	CCLE	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.3056
p.T396M	SNU-407	large intestine	COSMIC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation rewiring degron network	0.3056
p.T401I	SIDM00150	Colorectal Carcinoma	GDSC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation altering degron motif	0.5966
p.T401I	ACH-000969	Colon/Colorectal Cancer	CCLE	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation altering degron motif	0.5966
p.T401I	KM12	large intestine	COSMIC	PPTPTTS	DEG_SCF_FBW7_1	397:403	Mutation altering degron motif	0.5966
p.I429M	SIDM01322	Oral Cavity Carcinoma	GDSC	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.1389
p.I429M	ACH-000735	Head and Neck Cancer	CCLE	VTPPIS	DEG_SCF_FBW7_1	417:422	Mutation rewiring degron network	0.1389
p.T363R	ACH-000836	Head and Neck Cancer	CCLE	PLFTPAPS	DEG_SCF_FBW7_1	368:375	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FLRT2

UniProt ID: O43155

Entrez ID: 23768

Protein name: Leucine-rich repeat transmembrane protein FLRT2 (Fibronectin-like domain-containing leucine-rich transmembrane protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FLRT2 in