DegronMD

Uniprot ID: O43155

Source protein: Leucine-rich repeat transmembrane protein FLRT2

Source gene: FLRT2

Class: DEG_SCF_FBW7_1

Location: 368:375

E3 ligase: FBXW7

DEGRON score: 0.7654

ASA_SCORE: 83.6875

COIL: 0.8926

CONS_SCORE: 0.5696

DSS_SCORE: 0.6215

HELIX: 0.02

FCONS_SCORE: 0.8159

RIG_SCORE: 0.6649

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P365L	TCGA-A5-A0G1	UCEC	TCGA	PLFTPAPS	DEG_SCF_FBW7_1	0.25
p.P365L	DO42472	UCEC	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	0.25
p.L369R	TCGA-CD-5798	STAD	TCGA	PLFTPAPS	DEG_SCF_FBW7_1	0.7316
p.L369R	DO234191	ESAD	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	0.7316
p.L369R	DO38751	STAD	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	0.7316
p.S359F	TCGA-D3-A8GI	SKCM	TCGA	PLFTPAPS	DEG_SCF_FBW7_1	0.0833
p.S359F	DO50284	SKCM	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	0.0833
p.P379L	TCGA-DC-6155	READ	TCGA	PLFTPAPS	DEG_SCF_FBW7_1	0.2222
p.P379L	DO36953	READ	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	0.2222
p.P361S	TCGA-FS-A1ZZ	SKCM	TCGA	PLFTPAPS	DEG_SCF_FBW7_1	0.1389
p.P361S	TCGA-Z2-AA3S	SKCM	TCGA	PLFTPAPS	DEG_SCF_FBW7_1	0.1389
p.P361S	DO233830	GACA	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	0.1389
p.P361S	DO37412	SKCM	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	0.1389
p.P361S	DO51302	SKCM	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	0.1389
p.P384S	TCGA-WE-A8K1	SKCM	TCGA	PLFTPAPS	DEG_SCF_FBW7_1	0.0833
p.P384S	DO51280	SKCM	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	0.0833
p.P361L	TCGA-YD-A89C	SKCM	TCGA	PLFTPAPS	DEG_SCF_FBW7_1	0.1389
p.P361L	DO219501	SKCM	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	0.1389
p.P361L	SIDM01175	Other Sarcomas	GDSC	PLFTPAPS	DEG_SCF_FBW7_1	0.1389
p.P361L	ACH-001982	Metastasis	CCLE	PLFTPAPS	DEG_SCF_FBW7_1	0.1389
p.P361L	ACH-002309	Sarcoma	CCLE	PLFTPAPS	DEG_SCF_FBW7_1	0.1389
p.P361L	SW684	soft_tissue	COSMIC	PLFTPAPS	DEG_SCF_FBW7_1	0.1389
p.G366S	DO48381	BLCA	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	0.2778
p.T380S	DO6436	CLLE	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	0.1944
p.S375G	DO234449	ESAD	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	0.6993
p.S375G	DO234462	ESAD	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	0.6993
p.S375G	DO233145	GACA	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	0.6993
p.T376A	DO233903	GACA	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	0.3056
p.P374S	DO35083	PACA	ICGC	PLFTPAPS	DEG_SCF_FBW7_1	0.5641
p.T363R	ACH-000836	Head and Neck Cancer	CCLE	PLFTPAPS	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLFTPAPS

Degron related mutations and impact score

Drug responses associated with FLRT2 mutations

All proteins holding degron of PLFTPAPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43155	Leucine-rich repeat transmembrane protein FLRT2	DEG_SCF_FBW7_1	368:375	PLFTPAPS	FBXW7	0.7654	More...