DegronMD

Uniprot ID: O43155

Source protein: Leucine-rich repeat transmembrane protein FLRT2

Source gene: FLRT2

Class: DEG_SCF_FBW7_1

Location: 417:422

E3 ligase: FBXW7

DEGRON score: 0.9682

ASA_SCORE: 56.25

COIL: 0.8092

CONS_SCORE: 0.7067

DSS_SCORE: 0.3588

HELIX: 0.0197

FCONS_SCORE: 0.9946

RIG_SCORE: 0.7864

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W411R	TCGA-55-8511	LUAD	TCGA	VTPPIS	DEG_SCF_FBW7_1	0.1667
p.W411R	DO24940	LUAD	ICGC	VTPPIS	DEG_SCF_FBW7_1	0.1667
p.W411L	TCGA-55-8511	LUAD	TCGA	VTPPIS	DEG_SCF_FBW7_1	0.1667
p.W411L	DO24940	LUAD	ICGC	VTPPIS	DEG_SCF_FBW7_1	0.1667
p.R424W	TCGA-B6-A40C	BRCA	TCGA	VTPPIS	DEG_SCF_FBW7_1	0.2778
p.R424W	DO50045	BRCA	ICGC	VTPPIS	DEG_SCF_FBW7_1	0.2778
p.R424W	DO50946	LICA	ICGC	VTPPIS	DEG_SCF_FBW7_1	0.2778
p.R424W	DO51475	PACA	ICGC	VTPPIS	DEG_SCF_FBW7_1	0.2778
p.R424W	SIDM02013	Colorectal Carcinoma	GDSC	VTPPIS	DEG_SCF_FBW7_1	0.2778
p.G413D	TCGA-D7-5578	STAD	TCGA	VTPPIS	DEG_SCF_FBW7_1	0.2222
p.G413D	DO38475	STAD	ICGC	VTPPIS	DEG_SCF_FBW7_1	0.2222
p.S422F	TCGA-GN-A8LK	SKCM	TCGA	VTPPIS	DEG_SCF_FBW7_1	0.9093
p.S422F	DO51259	SKCM	ICGC	VTPPIS	DEG_SCF_FBW7_1	0.9093
p.D412G	TCGA-JX-A3Q0	CESC	TCGA	VTPPIS	DEG_SCF_FBW7_1	0.1944
p.D412G	DO51607	CESC	ICGC	VTPPIS	DEG_SCF_FBW7_1	0.1944
p.D410G	TCGA-UB-A7MB	LIHC	TCGA	VTPPIS	DEG_SCF_FBW7_1	0.1389
p.D410G	DO52318	LIHC	ICGC	VTPPIS	DEG_SCF_FBW7_1	0.1389
p.R424Q	TCGA-W3-AA1V	SKCM	TCGA	VTPPIS	DEG_SCF_FBW7_1	0.2778
p.R424Q	DO51276	SKCM	ICGC	VTPPIS	DEG_SCF_FBW7_1	0.2778
p.Q426P	TCGA-XF-A8HG	BLCA	TCGA	VTPPIS	DEG_SCF_FBW7_1	0.2222
p.Q426P	DO49802	BLCA	ICGC	VTPPIS	DEG_SCF_FBW7_1	0.2222
p.P420R	DO234464	ESAD	ICGC	VTPPIS	DEG_SCF_FBW7_1	0.6401
p.T407M	DO233867	GACA	ICGC	VTPPIS	DEG_SCF_FBW7_1	0.0556
p.D410Y	DO45089	LINC	ICGC	VTPPIS	DEG_SCF_FBW7_1	0.1389
p.R414K	DO45096	LIRI	ICGC	VTPPIS	DEG_SCF_FBW7_1	0.25
p.I429M	SIDM01322	Oral Cavity Carcinoma	GDSC	VTPPIS	DEG_SCF_FBW7_1	0.1389
p.I429M	ACH-000735	Head and Neck Cancer	CCLE	VTPPIS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43155	Leucine-rich repeat transmembrane protein FLRT2	DEG_SCF_FBW7_1	417:422	VTPPIS	FBXW7	0.9682	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons