DegronMD

Uniprot ID: O15054

Source protein: Lysine-specific demethylase 6B

Source gene: KDM6B

Class: DEG_SPOP_SBC_1

Location: 750:754

E3 ligase: SPOP

DEGRON score: 0.963

ASA_SCORE: 94.4

COIL: 0.9576

CONS_SCORE: 0.329

DSS_SCORE: 0.634

HELIX: 0.02

FCONS_SCORE: 0.8142

RIG_SCORE: 0.7419

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V751I	TCGA-B5-A3FC	UCEC	TCGA	AVTTT	DEG_SPOP_SBC_1	0.5965
p.V751I	DO41871	UCEC	ICGC	AVTTT	DEG_SPOP_SBC_1	0.5965
p.P747A	TCGA-FD-A3SP	BLCA	TCGA	AVTTT	DEG_SPOP_SBC_1	0.25
p.P747A	DO594	BLCA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.25
p.A750T	TCGA-PG-A917	UCEC	TCGA	AVTTT	DEG_SPOP_SBC_1	0.7139
p.A750T	DO52424	UCEC	ICGC	AVTTT	DEG_SPOP_SBC_1	0.7139
p.T761A	DO222867	BTCA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.1389
p.T761A	DO222913	BTCA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.1389
p.P747L	SIDM00333	Endometrial Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.25
p.P747L	MFE-319	endometrium	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.25
p.A763T	ACH-000969	Colon/Colorectal Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	750:754	AVTTT	SPOP	0.963	More...
O95104	SR-related and CTD-associated factor 4	DEG_SPOP_SBC_1	284:288	AVTTT	SPOP	0.5941	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	400:404	AVTTT	SPOP	0.6447	More...
Q6Q4G3	Aminopeptidase Q	DEG_SPOP_SBC_1	79:83	AVTTT	SPOP	0.9845	More...
Q86SE5	RNA-binding Raly-like protein	DEG_SPOP_SBC_1	162:166	AVTTT	SPOP	0.9953	More...
Q8IWI9	MAX gene-associated protein	DEG_SPOP_SBC_1	1596:1600	AVTTT	SPOP	0.5077	More...
Q9H3R2	Mucin-13	DEG_SPOP_SBC_1	27:31	AVTTT	SPOP	0.8418	More...
Q9NSU2	Three-prime repair exonuclease 1	DEG_SPOP_SBC_1	247:251	AVTTT	SPOP	0.9952	More...
Q9UKJ1	Paired immunoglobulin-like type 2 receptor alpha	DEG_SPOP_SBC_1	152:156	AVTTT	SPOP	0.5634	More...
Q9Y2H9	Microtubule-associated serine/threonine-protein kinase 1	DEG_SPOP_SBC_1	1048:1052	AVTTT	SPOP	0.8655	More...
Q9UKJ0	Paired immunoglobulin-like type 2 receptor beta	DEG_SPOP_SBC_1	152:156	AVTTT	SPOP	0.7899	More...
A2A368	Melanoma-associated antigen B16	DEG_SPOP_SBC_1	74:78	AVTTT	SPOP	0.5345	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons