DegronMD - Q6Q4G3(LVRN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R63S	SIDM01020	Plasma Cell Myeloma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.25
p.R63S	SIDM00194	Colorectal Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.25
p.R63S	SIDM00437	Acute Myeloid Leukemia	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.25
p.R63S	SIDM00064	Hepatocellular Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.25
p.R63S	SIDM00577	Neuroblastoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.25
p.R63S	SIDM00463	T-Lymphoblastic Leukemia	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.25
p.R63S	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.25
p.R63S	SIDM00533	Pancreatic Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.25
p.R63S	SIDM00040	Gastric Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.25
p.R63S	SIDM01196	Hepatocellular Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.25
p.R63S	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.25
p.R63S	SIDM00567	Other Solid Cancers	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.25
p.R63S	SIDM00988	Kidney Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.25
p.R63S	SIDM00241	Breast Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.25
p.R63S	SIDM01617	Endometrial Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.25
p.R63S	SIDM01578	Bladder Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.25
p.R63S	SIDM00163	Biliary Tract Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.25
p.R63S	SIDM01729	Endometrial Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.25
p.R76L	SIDM00770	Small Cell Lung Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.25
p.R76L	SIDM00770	Small Cell Lung Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	79:83	Mutation rewiring degron network	0.25
p.R76L	NCI-H1836	lung	COSMIC	PTPTPKPS	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.25
p.R76L	NCI-H1836	lung	COSMIC	AVTTT	DEG_SPOP_SBC_1	79:83	Mutation rewiring degron network	0.25
p.T83A	SIDM00364	B-Lymphoblastic Leukemia	GDSC	AVTTT	DEG_SPOP_SBC_1	79:83	Mutation altering degron motif	0.7139
p.T83A	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	AVTTT	DEG_SPOP_SBC_1	79:83	Mutation altering degron motif	0.7139
p.T83P	RCC-ER	kidney	COSMIC	AVTTT	DEG_SPOP_SBC_1	79:83	Mutation altering degron motif	0.7031

Kaplan plot for LVRN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LVRN

UniProt ID: Q6Q4G3

Entrez ID: 206338

Protein name: Aminopeptidase Q (AP-Q) (APQ) (EC 3.4.11.-) (CHL2 antigen) (Laeverin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LVRN in