DegronMD

Uniprot ID: Q6Q4G3

Source protein: Aminopeptidase Q

Source gene: LVRN

Class: DEG_SCF_FBW7_1

Location: 66:73

E3 ligase: FBXW7

DEGRON score: 0.6471

ASA_SCORE: 97.45

COIL: 0.9566

CONS_SCORE: 0.3997

DSS_SCORE: 0.7617

HELIX: 0.0228

FCONS_SCORE: 1.0169

RIG_SCORE: 0.553

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R63S	SIDM01020	Plasma Cell Myeloma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	0.25
p.R63S	SIDM00194	Colorectal Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	0.25
p.R63S	SIDM00437	Acute Myeloid Leukemia	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	0.25
p.R63S	SIDM00064	Hepatocellular Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	0.25
p.R63S	SIDM00577	Neuroblastoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	0.25
p.R63S	SIDM00463	T-Lymphoblastic Leukemia	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	0.25
p.R63S	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	0.25
p.R63S	SIDM00533	Pancreatic Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	0.25
p.R63S	SIDM00040	Gastric Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	0.25
p.R63S	SIDM01196	Hepatocellular Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	0.25
p.R63S	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	0.25
p.R63S	SIDM00567	Other Solid Cancers	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	0.25
p.R63S	SIDM00988	Kidney Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	0.25
p.R63S	SIDM00241	Breast Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	0.25
p.R63S	SIDM01617	Endometrial Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	0.25
p.R63S	SIDM01578	Bladder Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	0.25
p.R63S	SIDM00163	Biliary Tract Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	0.25
p.R63S	SIDM01729	Endometrial Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	0.25
p.R76L	SIDM00770	Small Cell Lung Carcinoma	GDSC	PTPTPKPS	DEG_SCF_FBW7_1	0.25
p.R76L	NCI-H1836	lung	COSMIC	PTPTPKPS	DEG_SCF_FBW7_1	0.25

Showing 1 to 20 of 20 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6Q4G3	Aminopeptidase Q	DEG_SCF_FBW7_1	66:73	PTPTPKPS	FBXW7	0.6471	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons