DegronMD

Uniprot ID: Q6Q4G3

Source protein: Aminopeptidase Q

Source gene: LVRN

Class: DEG_SPOP_SBC_1

Location: 79:83

E3 ligase: SPOP

DEGRON score: 0.9845

ASA_SCORE: 80.54

COIL: 0.8656

CONS_SCORE: 0.3974

DSS_SCORE: 0.6339

HELIX: 0.0244

FCONS_SCORE: 1.0115

RIG_SCORE: 0.6862

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R76L	SIDM00770	Small Cell Lung Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.25
p.R76L	NCI-H1836	lung	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.25
p.T83A	SIDM00364	B-Lymphoblastic Leukemia	GDSC	AVTTT	DEG_SPOP_SBC_1	0.7139
p.T83A	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.7139
p.T83P	RCC-ER	kidney	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	750:754	AVTTT	SPOP	0.963	More...
O95104	SR-related and CTD-associated factor 4	DEG_SPOP_SBC_1	284:288	AVTTT	SPOP	0.5941	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	400:404	AVTTT	SPOP	0.6447	More...
Q6Q4G3	Aminopeptidase Q	DEG_SPOP_SBC_1	79:83	AVTTT	SPOP	0.9845	More...
Q86SE5	RNA-binding Raly-like protein	DEG_SPOP_SBC_1	162:166	AVTTT	SPOP	0.9953	More...
Q8IWI9	MAX gene-associated protein	DEG_SPOP_SBC_1	1596:1600	AVTTT	SPOP	0.5077	More...
Q9H3R2	Mucin-13	DEG_SPOP_SBC_1	27:31	AVTTT	SPOP	0.8418	More...
Q9NSU2	Three-prime repair exonuclease 1	DEG_SPOP_SBC_1	247:251	AVTTT	SPOP	0.9952	More...
Q9UKJ1	Paired immunoglobulin-like type 2 receptor alpha	DEG_SPOP_SBC_1	152:156	AVTTT	SPOP	0.5634	More...
Q9Y2H9	Microtubule-associated serine/threonine-protein kinase 1	DEG_SPOP_SBC_1	1048:1052	AVTTT	SPOP	0.8655	More...
Q9UKJ0	Paired immunoglobulin-like type 2 receptor beta	DEG_SPOP_SBC_1	152:156	AVTTT	SPOP	0.7899	More...
A2A368	Melanoma-associated antigen B16	DEG_SPOP_SBC_1	74:78	AVTTT	SPOP	0.5345	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons