DegronMD - O95104(SCAF4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A852T	TCGA-27-2526	GBM	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.6028
p.A852T	TCGA-EI-6917	READ	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.6028
p.A852T	TCGA-HT-A5RC	LGG	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.6028
p.A852T	DO222817	BTCA	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.6028
p.A852T	DO13719	GBM	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.6028
p.A852T	DO48525	LGG	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.6028
p.A852T	DO36881	READ	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.6028
p.Q843K	TCGA-29-1698	OV	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.0833
p.Q843K	DO28531	OV	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.0833
p.Q843K	DO229272	THCA	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.0833
p.T831S	TCGA-37-4133	LUSC	TCGA	LPTPPVT	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.1111
p.T831S	DO26465	LUSC	ICGC	LPTPPVT	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.1111
p.M865K	TCGA-55-A48X	LUAD	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.1944
p.M865K	DO24048	LUAD	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.1944
p.S752F	TCGA-A5-A0G2	UCEC	TCGA	PPITPPVS	DEG_SCF_FBW7_1	745:752	Mutation altering degron motif	0.7982
p.P811A	TCGA-A6-A56B	COAD	TCGA	LPTPPVT	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.1667
p.G855S	TCGA-AA-3947	COAD	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.5882
p.G855S	TCGA-EO-A22U	UCEC	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.5882
p.G855S	DO8192	COAD	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.5882
p.G855S	DO43755	UCEC	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.5882
p.G855S	ACH-000673	Brain Cancer	CCLE	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.5882
p.V285I	TCGA-AP-A051	UCEC	TCGA	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.5965
p.V285I	DO42673	UCEC	ICGC	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.5965
p.L870S	TCGA-AP-A0LM	UCEC	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.0556
p.L870S	DO43306	UCEC	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.0556
p.L850F	TCGA-AP-A1DV	UCEC	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.2778
p.L850F	DO43186	UCEC	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.2778
p.F738Y	TCGA-AX-A2HC	UCEC	TCGA	PPITPPVS	DEG_SCF_FBW7_1	745:752	Mutation rewiring degron network	0.1389
p.F738Y	DO41572	UCEC	ICGC	PPITPPVS	DEG_SCF_FBW7_1	745:752	Mutation rewiring degron network	0.1389
p.P741S	TCGA-B5-A1MX	UCEC	TCGA	PPITPPVS	DEG_SCF_FBW7_1	745:752	Mutation rewiring degron network	0.2222
p.P741S	DO41999	UCEC	ICGC	PPITPPVS	DEG_SCF_FBW7_1	745:752	Mutation rewiring degron network	0.2222
p.R861H	TCGA-B7-5816	STAD	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.3056
p.R861H	DO38599	STAD	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.3056
p.A306T	TCGA-BR-7851	STAD	TCGA	APAAAVPPA	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.0833
p.A306T	DO38711	STAD	ICGC	APAAAVPPA	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.0833
p.P754S	TCGA-CV-7095	HNSC	TCGA	PPITPPVS	DEG_SCF_FBW7_1	745:752	Mutation rewiring degron network	0.2778
p.P754S	TCGA-CV-7095	HNSC	TCGA	PPHTPPIS	DEG_SCF_FBW7_1	755:762	Mutation rewiring degron network	0.3056
p.G830C	TCGA-D3-A2JC	SKCM	TCGA	LPTPPVT	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.1389
p.G830C	DO47578	SKCM	ICGC	LPTPPVT	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.1389
p.T287M	TCGA-DF-A2KU	UCEC	TCGA	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7423
p.T287M	DO223286	UCEC	ICGC	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7423
p.H757Q	TCGA-LT-A5Z6	BLCA	TCGA	PPHTPPIS	DEG_SCF_FBW7_1	755:762	Mutation altering degron motif	0.647
p.H757Q	DO44029	BLCA	ICGC	PPHTPPIS	DEG_SCF_FBW7_1	755:762	Mutation altering degron motif	0.647
p.T847A	TCGA-OR-A5J6	ACC	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.1944
p.P735Q	DO225028	BRCA	ICGC	PPITPPVS	DEG_SCF_FBW7_1	745:752	Mutation rewiring degron network	0.0556
p.T286I	DO234230	ESAD	ICGC	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7078
p.P739S	DO14252	HNSC	ICGC	PPITPPVS	DEG_SCF_FBW7_1	745:752	Mutation rewiring degron network	0.1667
p.P769T	DO228948	LICA	ICGC	PPHTPPIS	DEG_SCF_FBW7_1	755:762	Mutation rewiring degron network	0.1389
p.A306D	DO228948	LICA	ICGC	APAAAVPPA	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.0833
p.T288K	DO229027	LICA	ICGC	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7306
p.P298H	DO229035	LICA	ICGC	APAAAVPPA	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.3056
p.P298H	DO229035	LICA	ICGC	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.0556
p.S762N	DO23134	LINC	ICGC	PPHTPPIS	DEG_SCF_FBW7_1	755:762	Mutation altering degron motif	0.7069
p.I768M	DO222696	MELA	ICGC	PPHTPPIS	DEG_SCF_FBW7_1	755:762	Mutation rewiring degron network	0.1667
p.A808V	DO229218	THCA	ICGC	LPTPPVT	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.0833
p.S737F	DO41235	UCEC	ICGC	PPITPPVS	DEG_SCF_FBW7_1	745:752	Mutation rewiring degron network	0.1111
p.A300T	SIDM00216	Colorectal Carcinoma	GDSC	APAAAVPPA	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.25
p.A300T	ACH-000989	Colon/Colorectal Cancer	CCLE	APAAAVPPA	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.25
p.A300T	SNU-175	large intestine	COSMIC	APAAAVPPA	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.25
p.V274M	SIDM01178	Other Solid Cancers	GDSC	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.0556
p.V274M	ACH-002200	Skin Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.0556
p.V274M	SW962	vulva	COSMIC	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.0556
p.S766F	SIDM00282	Colorectal Carcinoma	GDSC	PPHTPPIS	DEG_SCF_FBW7_1	755:762	Mutation rewiring degron network	0.2222
p.S766F	CW-2	large intestine	COSMIC	PPHTPPIS	DEG_SCF_FBW7_1	755:762	Mutation rewiring degron network	0.2222
p.K279Q	SIDM00754	Non-Small Cell Lung Carcinoma	GDSC	APAAAVPPA	DEG_SIAH_1	289:297	Mutation substituting flanking lysine	0.1667
p.K279Q	SIDM00754	Non-Small Cell Lung Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation substituting flanking lysine	0.3056
p.K279Q	ACH-000379	Lung Cancer	CCLE	APAAAVPPA	DEG_SIAH_1	289:297	Mutation substituting flanking lysine	0.1667
p.K279Q	ACH-000379	Lung Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation substituting flanking lysine	0.3056
p.K279Q	NCI-H1781	lung	COSMIC	APAAAVPPA	DEG_SIAH_1	289:297	Mutation substituting flanking lysine	0.1667
p.K279Q	NCI-H1781	lung	COSMIC	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation substituting flanking lysine	0.3056
p.Q832K	SIDM00151	Ovarian Carcinoma	GDSC	LPTPPVT	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.0833
p.Q832K	ACH-000966	Ovarian Cancer	CCLE	LPTPPVT	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.0833
p.Q832K	IGROV-1	ovary	COSMIC	LPTPPVT	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.0833
p.N816S	SIDM00035	Thyroid Gland Carcinoma	GDSC	LPTPPVT	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.3056
p.P298L	SIDM00516	Melanoma	GDSC	APAAAVPPA	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.3056
p.P298L	SIDM00516	Melanoma	GDSC	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.0556
p.P298L	ACH-002166	Skin Cancer	CCLE	APAAAVPPA	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.3056
p.P298L	ACH-002166	Skin Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.0556
p.P298L	MZ7-mel	skin	COSMIC	APAAAVPPA	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.3056
p.P298L	MZ7-mel	skin	COSMIC	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.0556
p.F738V	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PPITPPVS	DEG_SCF_FBW7_1	745:752	Mutation rewiring degron network	0.1389
p.F738V	ACH-002222	Leukemia	CCLE	PPITPPVS	DEG_SCF_FBW7_1	745:752	Mutation rewiring degron network	0.1389
p.F738V	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PPITPPVS	DEG_SCF_FBW7_1	745:752	Mutation rewiring degron network	0.1389
p.A304D	ACH-002061	Leukemia	CCLE	APAAAVPPA	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.1389
p.P862S	ACH-002269	Brain Cancer	CCLE	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.2778
p.P283L	MZ7-mel	skin	COSMIC	APAAAVPPA	DEG_SIAH_1	289:297	Mutation rewiring degron network	0.1667
p.P283L	MZ7-mel	skin	COSMIC	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.3056
p.A285T	SNU-175	large intestine	COSMIC	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7139
p.R857Q	GP5d	large intestine	COSMIC	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.7329
p.Q810K	IGROV-1	ovary	COSMIC	LPTPPVT	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.1389
p.R850Q	GP5d	large intestine	COSMIC	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation rewiring degron network	0.2778
p.A294T	H2869	pleura	COSMIC	APAAAVPPA	DEG_SIAH_1	289:297	Mutation altering degron motif	0.7139
p.S751F	CW-2	large intestine	COSMIC	PPITPPVS	DEG_SCF_FBW7_1	745:752	Mutation altering degron motif	0.7982
p.Q817K	IGROV-1	ovary	COSMIC	LPTPPVT	DEG_SCF_FBW7_1	817:823	Mutation altering degron motif	0.6944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCAF4

UniProt ID: O95104

Entrez ID: 57466

Protein name: SR-related and CTD-associated factor 4 (CTD-binding SR-like protein RA4) (Splicing factor, arginine/serine-rich 15)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCAF4 in