DegronMD - O95104(SCAF4)

FUNCTION: Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mecha... View more >>

GO - Biological processes (BP): mRNA processing [GO:0006397]; negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000805]

GO - Molecular function (MF): protein C-terminus binding [GO:0008022]; RNA binding [GO:0003723]; RNA polymerase II C-terminal domain phosphoserine binding [GO:1990269]

GO - Cellular component (CC): nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S752F	TCGA-A5-A0G2	UCEC	TCGA	PPITPPVS	DEG_SCF_FBW7_1	745:752	Mutation altering degron motif	0.7982
p.S751F	CW-2	large intestine	COSMIC	PPITPPVS	DEG_SCF_FBW7_1	745:752	Mutation altering degron motif	0.7982
p.T287M	TCGA-DF-A2KU	UCEC	TCGA	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7423
p.T287M	DO223286	UCEC	ICGC	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7423
p.R857Q	GP5d	large intestine	COSMIC	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.7329
p.T288K	DO229027	LICA	ICGC	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7306
p.A285T	SNU-175	large intestine	COSMIC	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7139
p.A294T	H2869	pleura	COSMIC	APAAAVPPA	DEG_SIAH_1	289:297	Mutation altering degron motif	0.7139
p.T286I	DO234230	ESAD	ICGC	AVTTT	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7078
p.S762N	DO23134	LINC	ICGC	PPHTPPIS	DEG_SCF_FBW7_1	755:762	Mutation altering degron motif	0.7069
p.Q817K	IGROV-1	ovary	COSMIC	LPTPPVT	DEG_SCF_FBW7_1	817:823	Mutation altering degron motif	0.6944
p.H757Q	TCGA-LT-A5Z6	BLCA	TCGA	PPHTPPIS	DEG_SCF_FBW7_1	755:762	Mutation altering degron motif	0.647
p.H757Q	DO44029	BLCA	ICGC	PPHTPPIS	DEG_SCF_FBW7_1	755:762	Mutation altering degron motif	0.647
p.A852T	TCGA-27-2526	GBM	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.6028
p.A852T	TCGA-EI-6917	READ	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.6028
p.A852T	TCGA-HT-A5RC	LGG	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.6028
p.A852T	DO222817	BTCA	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.6028
p.A852T	DO13719	GBM	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.6028
p.A852T	DO48525	LGG	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.6028
p.A852T	DO36881	READ	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	852:860	Mutation altering degron motif	0.6028

Showing 1 to 20 of 94 entries

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCAF4

UniProt ID: O95104

Entrez ID: 57466

Protein name: SR-related and CTD-associated factor 4 (CTD-binding SR-like protein RA4) (Splicing factor, arginine/serine-rich 15)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCAF4 in