DegronMD

Uniprot ID: O95104

Source protein: SR-related and CTD-associated factor 4

Source gene: SCAF4

Class: DEG_SCF_FBW7_1

Location: 755:762

E3 ligase: FBXW7

DEGRON score: 0.9752

ASA_SCORE: 92.0375

COIL: 0.9696

CONS_SCORE: 0.3455

DSS_SCORE: 0.6063

HELIX: 0.0116

FCONS_SCORE: 0.9956

RIG_SCORE: 0.6161

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P754S	TCGA-CV-7095	HNSC	TCGA	PPHTPPIS	DEG_SCF_FBW7_1	0.3056
p.H757Q	TCGA-LT-A5Z6	BLCA	TCGA	PPHTPPIS	DEG_SCF_FBW7_1	0.647
p.H757Q	DO44029	BLCA	ICGC	PPHTPPIS	DEG_SCF_FBW7_1	0.647
p.P769T	DO228948	LICA	ICGC	PPHTPPIS	DEG_SCF_FBW7_1	0.1389
p.S762N	DO23134	LINC	ICGC	PPHTPPIS	DEG_SCF_FBW7_1	0.7069
p.I768M	DO222696	MELA	ICGC	PPHTPPIS	DEG_SCF_FBW7_1	0.1667
p.S766F	SIDM00282	Colorectal Carcinoma	GDSC	PPHTPPIS	DEG_SCF_FBW7_1	0.2222
p.S766F	CW-2	large_intestine	COSMIC	PPHTPPIS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95104	SR-related and CTD-associated factor 4	DEG_SCF_FBW7_1	755:762	PPHTPPIS	FBXW7	0.9752	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons