DegronMD

Uniprot ID: O95104

Source protein: SR-related and CTD-associated factor 4

Source gene: SCAF4

Class: DEG_SCF_FBW7_1

Location: 745:752

E3 ligase: FBXW7

DEGRON score: 0.9449

ASA_SCORE: 96.7875

COIL: 0.9739

CONS_SCORE: 0.3835

DSS_SCORE: 0.6658

HELIX: 0.0094

FCONS_SCORE: 0.9284

RIG_SCORE: 0.5627

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S752F	TCGA-A5-A0G2	UCEC	TCGA	PPITPPVS	DEG_SCF_FBW7_1	0.7982
p.F738Y	TCGA-AX-A2HC	UCEC	TCGA	PPITPPVS	DEG_SCF_FBW7_1	0.1389
p.F738Y	DO41572	UCEC	ICGC	PPITPPVS	DEG_SCF_FBW7_1	0.1389
p.P741S	TCGA-B5-A1MX	UCEC	TCGA	PPITPPVS	DEG_SCF_FBW7_1	0.2222
p.P741S	DO41999	UCEC	ICGC	PPITPPVS	DEG_SCF_FBW7_1	0.2222
p.P754S	TCGA-CV-7095	HNSC	TCGA	PPITPPVS	DEG_SCF_FBW7_1	0.2778
p.P735Q	DO225028	BRCA	ICGC	PPITPPVS	DEG_SCF_FBW7_1	0.0556
p.P739S	DO14252	HNSC	ICGC	PPITPPVS	DEG_SCF_FBW7_1	0.1667
p.S737F	DO41235	UCEC	ICGC	PPITPPVS	DEG_SCF_FBW7_1	0.1111
p.F738V	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PPITPPVS	DEG_SCF_FBW7_1	0.1389
p.F738V	ACH-002222	Leukemia	CCLE	PPITPPVS	DEG_SCF_FBW7_1	0.1389
p.F738V	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PPITPPVS	DEG_SCF_FBW7_1	0.1389
p.S751F	CW-2	large_intestine	COSMIC	PPITPPVS	DEG_SCF_FBW7_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95104	SR-related and CTD-associated factor 4	DEG_SCF_FBW7_1	745:752	PPITPPVS	FBXW7	0.9449	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons