DegronMD

Uniprot ID: O95104

Source protein: SR-related and CTD-associated factor 4

Source gene: SCAF4

Class: DEG_SIAH_1

Location: 289:297

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9955

ASA_SCORE: 81.1889

COIL: 0.9508

CONS_SCORE: 0.2346

DSS_SCORE: 0.5565

HELIX: 0.0338

FCONS_SCORE: 0.8842

RIG_SCORE: 0.6741

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A306T	TCGA-BR-7851	STAD	TCGA	APAAAVPPA	DEG_SIAH_1	0.0833
p.A306T	DO38711	STAD	ICGC	APAAAVPPA	DEG_SIAH_1	0.0833
p.A306D	DO228948	LICA	ICGC	APAAAVPPA	DEG_SIAH_1	0.0833
p.P298H	DO229035	LICA	ICGC	APAAAVPPA	DEG_SIAH_1	0.3056
p.A300T	SIDM00216	Colorectal Carcinoma	GDSC	APAAAVPPA	DEG_SIAH_1	0.25
p.A300T	ACH-000989	Colon/Colorectal Cancer	CCLE	APAAAVPPA	DEG_SIAH_1	0.25
p.A300T	SNU-175	large_intestine	COSMIC	APAAAVPPA	DEG_SIAH_1	0.25
p.K279Q	SIDM00754	Non-Small Cell Lung Carcinoma	GDSC	APAAAVPPA	DEG_SIAH_1	0.1667
p.K279Q	ACH-000379	Lung Cancer	CCLE	APAAAVPPA	DEG_SIAH_1	0.1667
p.K279Q	NCI-H1781	lung	COSMIC	APAAAVPPA	DEG_SIAH_1	0.1667
p.P298L	SIDM00516	Melanoma	GDSC	APAAAVPPA	DEG_SIAH_1	0.3056
p.P298L	ACH-002166	Skin Cancer	CCLE	APAAAVPPA	DEG_SIAH_1	0.3056
p.P298L	MZ7-mel	skin	COSMIC	APAAAVPPA	DEG_SIAH_1	0.3056
p.A304D	ACH-002061	Leukemia	CCLE	APAAAVPPA	DEG_SIAH_1	0.1389
p.P283L	MZ7-mel	skin	COSMIC	APAAAVPPA	DEG_SIAH_1	0.1667
p.A294T	H2869	pleura	COSMIC	APAAAVPPA	DEG_SIAH_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95104	SR-related and CTD-associated factor 4	DEG_SIAH_1	289:297	APAAAVPPA	SIAH1,SIAH2,SIAH3	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons