DegronMD

Uniprot ID: O95104

Source protein: SR-related and CTD-associated factor 4

Source gene: SCAF4

Class: DEG_SCF_FBW7_1

Location: 817:823

E3 ligase: FBXW7

DEGRON score: 0.9835

ASA_SCORE: 85.9286

COIL: 0.9684

CONS_SCORE: 0.3217

DSS_SCORE: 0.5376

HELIX: 0.0147

FCONS_SCORE: 1.0169

RIG_SCORE: 0.6818

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T831S	TCGA-37-4133	LUSC	TCGA	LPTPPVT	DEG_SCF_FBW7_1	0.1111
p.T831S	DO26465	LUSC	ICGC	LPTPPVT	DEG_SCF_FBW7_1	0.1111
p.P811A	TCGA-A6-A56B	COAD	TCGA	LPTPPVT	DEG_SCF_FBW7_1	0.1667
p.G830C	TCGA-D3-A2JC	SKCM	TCGA	LPTPPVT	DEG_SCF_FBW7_1	0.1389
p.G830C	DO47578	SKCM	ICGC	LPTPPVT	DEG_SCF_FBW7_1	0.1389
p.A808V	DO229218	THCA	ICGC	LPTPPVT	DEG_SCF_FBW7_1	0.0833
p.Q832K	SIDM00151	Ovarian Carcinoma	GDSC	LPTPPVT	DEG_SCF_FBW7_1	0.0833
p.Q832K	ACH-000966	Ovarian Cancer	CCLE	LPTPPVT	DEG_SCF_FBW7_1	0.0833
p.Q832K	IGROV-1	ovary	COSMIC	LPTPPVT	DEG_SCF_FBW7_1	0.0833
p.N816S	SIDM00035	Thyroid Gland Carcinoma	GDSC	LPTPPVT	DEG_SCF_FBW7_1	0.3056
p.Q810K	IGROV-1	ovary	COSMIC	LPTPPVT	DEG_SCF_FBW7_1	0.1389
p.Q817K	IGROV-1	ovary	COSMIC	LPTPPVT	DEG_SCF_FBW7_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95104	SR-related and CTD-associated factor 4	DEG_SCF_FBW7_1	817:823	LPTPPVT	FBXW7	0.9835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons