DegronMD

Uniprot ID: O95104

Source protein: SR-related and CTD-associated factor 4

Source gene: SCAF4

Class: DEG_APCC_DBOX_1

Location: 852:860

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9939

ASA_SCORE: 81.7556

COIL: 0.9302

CONS_SCORE: 0.4328

DSS_SCORE: 0.5797

HELIX: 0.0297

FCONS_SCORE: 1.1381

RIG_SCORE: 0.6684

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A852T	TCGA-27-2526	GBM	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	0.6028
p.A852T	TCGA-EI-6917	READ	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	0.6028
p.A852T	TCGA-HT-A5RC	LGG	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	0.6028
p.A852T	DO222817	BTCA	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	0.6028
p.A852T	DO13719	GBM	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	0.6028
p.A852T	DO48525	LGG	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	0.6028
p.A852T	DO36881	READ	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	0.6028
p.Q843K	TCGA-29-1698	OV	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	0.0833
p.Q843K	DO28531	OV	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	0.0833
p.Q843K	DO229272	THCA	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	0.0833
p.M865K	TCGA-55-A48X	LUAD	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	0.1944
p.M865K	DO24048	LUAD	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	0.1944
p.G855S	TCGA-AA-3947	COAD	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	0.5882
p.G855S	TCGA-EO-A22U	UCEC	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	0.5882
p.G855S	DO8192	COAD	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	0.5882
p.G855S	DO43755	UCEC	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	0.5882
p.G855S	ACH-000673	Brain Cancer	CCLE	ARPGLIPLQ	DEG_APCC_DBOX_1	0.5882
p.L870S	TCGA-AP-A0LM	UCEC	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	0.0556
p.L870S	DO43306	UCEC	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	0.0556
p.L850F	TCGA-AP-A1DV	UCEC	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	0.2778
p.L850F	DO43186	UCEC	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	0.2778
p.R861H	TCGA-B7-5816	STAD	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	0.3056
p.R861H	DO38599	STAD	ICGC	ARPGLIPLQ	DEG_APCC_DBOX_1	0.3056
p.T847A	TCGA-OR-A5J6	ACC	TCGA	ARPGLIPLQ	DEG_APCC_DBOX_1	0.1944
p.P862S	ACH-002269	Brain Cancer	CCLE	ARPGLIPLQ	DEG_APCC_DBOX_1	0.2778
p.R857Q	GP5d	large_intestine	COSMIC	ARPGLIPLQ	DEG_APCC_DBOX_1	0.7329
p.R850Q	GP5d	large_intestine	COSMIC	ARPGLIPLQ	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95104	SR-related and CTD-associated factor 4	DEG_APCC_DBOX_1	852:860	ARPGLIPLQ	APC,CDC20,FZR1	0.9939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARPGLIPLQ

Degron related mutations and impact score

Drug responses associated with SCAF4 mutations

All proteins holding degron of ARPGLIPLQ