DegronMD

Uniprot ID: O95104

Source protein: SR-related and CTD-associated factor 4

Source gene: SCAF4

Class: DEG_SPOP_SBC_1

Location: 284:288

E3 ligase: SPOP

DEGRON score: 0.5941

ASA_SCORE: 94.78

COIL: 0.902

CONS_SCORE: 0.2412

DSS_SCORE: 0.5853

HELIX: 0.0664

FCONS_SCORE: 0.8233

RIG_SCORE: 0.7438

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V285I	TCGA-AP-A051	UCEC	TCGA	AVTTT	DEG_SPOP_SBC_1	0.5965
p.V285I	DO42673	UCEC	ICGC	AVTTT	DEG_SPOP_SBC_1	0.5965
p.T287M	TCGA-DF-A2KU	UCEC	TCGA	AVTTT	DEG_SPOP_SBC_1	0.7423
p.T287M	DO223286	UCEC	ICGC	AVTTT	DEG_SPOP_SBC_1	0.7423
p.T286I	DO234230	ESAD	ICGC	AVTTT	DEG_SPOP_SBC_1	0.7078
p.T288K	DO229027	LICA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.7306
p.P298H	DO229035	LICA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.0556
p.V274M	SIDM01178	Other Solid Cancers	GDSC	AVTTT	DEG_SPOP_SBC_1	0.0556
p.V274M	ACH-002200	Skin Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	0.0556
p.V274M	SW962	vulva	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.0556
p.K279Q	SIDM00754	Non-Small Cell Lung Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.3056
p.K279Q	ACH-000379	Lung Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	0.3056
p.K279Q	NCI-H1781	lung	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.3056
p.P298L	SIDM00516	Melanoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.0556
p.P298L	ACH-002166	Skin Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	0.0556
p.P298L	MZ7-mel	skin	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.0556
p.P283L	MZ7-mel	skin	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.3056
p.A285T	SNU-175	large_intestine	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	750:754	AVTTT	SPOP	0.963	More...
O95104	SR-related and CTD-associated factor 4	DEG_SPOP_SBC_1	284:288	AVTTT	SPOP	0.5941	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	400:404	AVTTT	SPOP	0.6447	More...
Q6Q4G3	Aminopeptidase Q	DEG_SPOP_SBC_1	79:83	AVTTT	SPOP	0.9845	More...
Q86SE5	RNA-binding Raly-like protein	DEG_SPOP_SBC_1	162:166	AVTTT	SPOP	0.9953	More...
Q8IWI9	MAX gene-associated protein	DEG_SPOP_SBC_1	1596:1600	AVTTT	SPOP	0.5077	More...
Q9H3R2	Mucin-13	DEG_SPOP_SBC_1	27:31	AVTTT	SPOP	0.8418	More...
Q9NSU2	Three-prime repair exonuclease 1	DEG_SPOP_SBC_1	247:251	AVTTT	SPOP	0.9952	More...
Q9UKJ1	Paired immunoglobulin-like type 2 receptor alpha	DEG_SPOP_SBC_1	152:156	AVTTT	SPOP	0.5634	More...
Q9Y2H9	Microtubule-associated serine/threonine-protein kinase 1	DEG_SPOP_SBC_1	1048:1052	AVTTT	SPOP	0.8655	More...
Q9UKJ0	Paired immunoglobulin-like type 2 receptor beta	DEG_SPOP_SBC_1	152:156	AVTTT	SPOP	0.7899	More...
A2A368	Melanoma-associated antigen B16	DEG_SPOP_SBC_1	74:78	AVTTT	SPOP	0.5345	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons