DegronMD

Uniprot ID: A2A368

Source protein: Melanoma-associated antigen B16

Source gene: MAGEB16

Class: DEG_SPOP_SBC_1

Location: 74:78

E3 ligase: SPOP

DEGRON score: 0.5345

ASA_SCORE: 85.1

COIL: 0.8784

CONS_SCORE: 0.2545

DSS_SCORE: 0.5666

HELIX: 0.0562

FCONS_SCORE: 0.8674

RIG_SCORE: 0.6539

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S72Y	TCGA-06-5416	GBM	TCGA	AVTTT	DEG_SPOP_SBC_1	0.2778
p.S72Y	DO10880	GBM	ICGC	AVTTT	DEG_SPOP_SBC_1	0.2778
p.Q66H	TCGA-85-A4JC	LUSC	TCGA	AVTTT	DEG_SPOP_SBC_1	0.1111
p.Q66H	DO45429	LUSC	ICGC	AVTTT	DEG_SPOP_SBC_1	0.1111
p.S88N	TCGA-D3-A5GO	SKCM	TCGA	AVTTT	DEG_SPOP_SBC_1	0.0556
p.S88N	DO47419	SKCM	ICGC	AVTTT	DEG_SPOP_SBC_1	0.0556
p.E82K	TCGA-E7-A7PW	BLCA	TCGA	AVTTT	DEG_SPOP_SBC_1	0.2222
p.E82K	DO219017	BLCA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.2222
p.V64I	TCGA-OL-A5DA	BRCA	TCGA	AVTTT	DEG_SPOP_SBC_1	0.0556
p.V64I	DO44121	BRCA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.0556
p.C69F	TCGA-X7-A8M3	THYM	TCGA	AVTTT	DEG_SPOP_SBC_1	0.1944
p.V75I	DO227975	COCA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.5965
p.V75I	DO233764	GACA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.5965
p.V75I	SIDM00186	Kidney Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.5965
p.V75I	SIDM00858	Osteosarcoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.5965
p.V75I	SIDM01157	Other Solid Cancers	GDSC	AVTTT	DEG_SPOP_SBC_1	0.5965
p.V75I	SIDM01651	Non-Cancerous	GDSC	AVTTT	DEG_SPOP_SBC_1	0.5965
p.T76I	DO231984	LICA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.7078
p.A74V	DO50970	LICA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.5825
p.A74V	SIDM01679	Small Cell Lung Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.5825
p.A74V	ACH-000523	Lung Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	0.5825
p.S67N	DO52361	LUSC	ICGC	AVTTT	DEG_SPOP_SBC_1	0.1389
p.P65S	DO220857	MELA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.0833
p.P65S	DO220905	MELA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.0833
p.S83Y	SIDM01588	Endometrial Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.1944
p.S83Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	0.1944
p.A86D	ACH-000208	Brain Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	750:754	AVTTT	SPOP	0.963	More...
O95104	SR-related and CTD-associated factor 4	DEG_SPOP_SBC_1	284:288	AVTTT	SPOP	0.5941	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	400:404	AVTTT	SPOP	0.6447	More...
Q6Q4G3	Aminopeptidase Q	DEG_SPOP_SBC_1	79:83	AVTTT	SPOP	0.9845	More...
Q86SE5	RNA-binding Raly-like protein	DEG_SPOP_SBC_1	162:166	AVTTT	SPOP	0.9953	More...
Q8IWI9	MAX gene-associated protein	DEG_SPOP_SBC_1	1596:1600	AVTTT	SPOP	0.5077	More...
Q9H3R2	Mucin-13	DEG_SPOP_SBC_1	27:31	AVTTT	SPOP	0.8418	More...
Q9NSU2	Three-prime repair exonuclease 1	DEG_SPOP_SBC_1	247:251	AVTTT	SPOP	0.9952	More...
Q9UKJ1	Paired immunoglobulin-like type 2 receptor alpha	DEG_SPOP_SBC_1	152:156	AVTTT	SPOP	0.5634	More...
Q9Y2H9	Microtubule-associated serine/threonine-protein kinase 1	DEG_SPOP_SBC_1	1048:1052	AVTTT	SPOP	0.8655	More...
Q9UKJ0	Paired immunoglobulin-like type 2 receptor beta	DEG_SPOP_SBC_1	152:156	AVTTT	SPOP	0.7899	More...
A2A368	Melanoma-associated antigen B16	DEG_SPOP_SBC_1	74:78	AVTTT	SPOP	0.5345	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AVTTT

Degron related mutations and impact score

Drug responses associated with MAGEB16 mutations

All proteins holding degron of AVTTT