DegronMD

Uniprot ID: Q9Y2H9

Source protein: Microtubule-associated serine/threonine-protein kinase 1

Source gene: MAST1

Class: DEG_SPOP_SBC_1

Location: 1048:1052

E3 ligase: SPOP

DEGRON score: 0.8655

ASA_SCORE: 51.32

COIL: 0.3146

CONS_SCORE: 0.4074

DSS_SCORE: 0.3502

HELIX: 0.0094

FCONS_SCORE: 0.9146

RIG_SCORE: 0.813

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1058F	TCGA-A5-A0G2	UCEC	TCGA	AVTTT	DEG_SPOP_SBC_1	0.1667
p.S1058F	DO41235	UCEC	ICGC	AVTTT	DEG_SPOP_SBC_1	0.1667
p.V1047E	TCGA-BB-A5HY	HNSC	TCGA	AVTTT	DEG_SPOP_SBC_1	0.3056
p.V1047E	DO218979	HNSC	ICGC	AVTTT	DEG_SPOP_SBC_1	0.3056
p.E1055K	TCGA-BG-A221	UCEC	TCGA	AVTTT	DEG_SPOP_SBC_1	0.25
p.E1055K	TCGA-ND-A4WC	UCS	TCGA	AVTTT	DEG_SPOP_SBC_1	0.25
p.E1055K	DO224642	PACA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.25
p.E1055K	DO42384	UCEC	ICGC	AVTTT	DEG_SPOP_SBC_1	0.25
p.S1043N	TCGA-EE-A29L	SKCM	TCGA	AVTTT	DEG_SPOP_SBC_1	0.1944
p.S1043N	DO222599	MELA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.1944
p.S1043N	DO37835	SKCM	ICGC	AVTTT	DEG_SPOP_SBC_1	0.1944
p.A1048P	TCGA-FU-A23K	CESC	TCGA	AVTTT	DEG_SPOP_SBC_1	0.6392
p.A1048P	DO6305	CESC	ICGC	AVTTT	DEG_SPOP_SBC_1	0.6392
p.R1060C	DO225337	BRCA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.1111
p.R1060C	SIDM01263	T-Lymphoblastic Leukemia	GDSC	AVTTT	DEG_SPOP_SBC_1	0.1111
p.T1057A	DO233823	GACA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.1944
p.A1048S	SIDM00629	Breast Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.7588
p.A1048S	SIDM00258	Neuroblastoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.7588
p.G1062V	SIDM01036	Plasma Cell Myeloma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.0556
p.G1062V	ACH-000653	Myeloma	CCLE	AVTTT	DEG_SPOP_SBC_1	0.0556
p.G1062V	JJN-3	haematopoietic_and_lymphoid_tissue	COSMIC	AVTTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	750:754	AVTTT	SPOP	0.963	More...
O95104	SR-related and CTD-associated factor 4	DEG_SPOP_SBC_1	284:288	AVTTT	SPOP	0.5941	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	400:404	AVTTT	SPOP	0.6447	More...
Q6Q4G3	Aminopeptidase Q	DEG_SPOP_SBC_1	79:83	AVTTT	SPOP	0.9845	More...
Q86SE5	RNA-binding Raly-like protein	DEG_SPOP_SBC_1	162:166	AVTTT	SPOP	0.9953	More...
Q8IWI9	MAX gene-associated protein	DEG_SPOP_SBC_1	1596:1600	AVTTT	SPOP	0.5077	More...
Q9H3R2	Mucin-13	DEG_SPOP_SBC_1	27:31	AVTTT	SPOP	0.8418	More...
Q9NSU2	Three-prime repair exonuclease 1	DEG_SPOP_SBC_1	247:251	AVTTT	SPOP	0.9952	More...
Q9UKJ1	Paired immunoglobulin-like type 2 receptor alpha	DEG_SPOP_SBC_1	152:156	AVTTT	SPOP	0.5634	More...
Q9Y2H9	Microtubule-associated serine/threonine-protein kinase 1	DEG_SPOP_SBC_1	1048:1052	AVTTT	SPOP	0.8655	More...
Q9UKJ0	Paired immunoglobulin-like type 2 receptor beta	DEG_SPOP_SBC_1	152:156	AVTTT	SPOP	0.7899	More...
A2A368	Melanoma-associated antigen B16	DEG_SPOP_SBC_1	74:78	AVTTT	SPOP	0.5345	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons