DegronMD - Q9UKJ0(PILRB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K143N	TCGA-05-4390	LUAD	TCGA	AVTTT	DEG_SPOP_SBC_1	152:156	Mutation substituting flanking lysine	0.1944
p.K143N	DO23562	LUAD	ICGC	AVTTT	DEG_SPOP_SBC_1	152:156	Mutation substituting flanking lysine	0.1944
p.A152D	TCGA-AP-A059	UCEC	TCGA	AVTTT	DEG_SPOP_SBC_1	152:156	Mutation altering degron motif	0.7793
p.A152D	DO41361	UCEC	ICGC	AVTTT	DEG_SPOP_SBC_1	152:156	Mutation altering degron motif	0.7793
p.G169S	TCGA-B5-A11E	UCEC	TCGA	PSSTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2222
p.G169S	DO41644	UCEC	ICGC	PSSTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2222
p.T145I	DO7250	CLLE	ICGC	AVTTT	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1389
p.T148S	DO234149	ESAD	ICGC	AVTTT	DEG_SPOP_SBC_1	152:156	Mutation blocking phosphorylation signal	0.6667
p.R155G	DO233262	GACA	ICGC	AVTTT	DEG_SPOP_SBC_1	152:156	Mutation altering degron motif	0.7568
p.A149S	DO229022	LICA	ICGC	AVTTT	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.25
p.R160W	DO41871	UCEC	ICGC	AVTTT	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.2222
p.R160W	DO41871	UCEC	ICGC	PSSTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.3056
p.L147V	SIDM00961	Ewing's Sarcoma	GDSC	AVTTT	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1944
p.L147V	SIDM01144	Gastric Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1944
p.L147V	SIDM00247	Gastric Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1944
p.L147V	SIDM00289	B-Lymphoblastic Leukemia	GDSC	AVTTT	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1944
p.L147V	SIDM00603	Head and Neck Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1944
p.L147V	SIDM01659	Kidney Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1944
p.L147V	SIDM01770	Gastric Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1944
p.L147V	SIDM01469	Pancreatic Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1944
p.S163N	SIDM00303	Ovarian Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7069
p.S163N	ACH-000584	Ovarian Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7069
p.S163N	JHOS-4	ovary	COSMIC	PSSTT	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7069
p.I167V	SIDM00203	Ewing's Sarcoma	GDSC	PSSTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2778
p.I167V	ACH-002111	Bone Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2778
p.I167V	EW-11	bone	COSMIC	PSSTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2778
p.S162R	SIDM00124	Kidney Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.6316
p.S162R	A498	kidney	COSMIC	PSSTT	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.6316
p.K146N	SIDM01774	Pancreatic Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	152:156	Mutation substituting flanking lysine	0.2778
p.K146N	ACH-000205	Pancreatic Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	152:156	Mutation substituting flanking lysine	0.2778
p.K146N	ACH-002024	Colon/Colorectal Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	152:156	Mutation substituting flanking lysine	0.2778
p.G171R	COR-L303	lung	COSMIC	PSSTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1667

Kaplan plot for PILRB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PILRB

UniProt ID: Q9UKJ0

Entrez ID: 29990

Protein name: Paired immunoglobulin-like type 2 receptor beta (Activating receptor PILR-beta) (Cell surface receptor FDFACT)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PILRB in