DegronMD

Uniprot ID: Q9UKJ0

Source protein: Paired immunoglobulin-like type 2 receptor beta

Source gene: PILRB

Class: DEG_SPOP_SBC_1

Location: 152:156

E3 ligase: SPOP

DEGRON score: 0.7899

ASA_SCORE: 83

COIL: 0.84

CONS_SCORE: 0.5166

DSS_SCORE: 0.4404

HELIX: 0.0144

FCONS_SCORE: 1.2978

RIG_SCORE: 0.8199

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K143N	TCGA-05-4390	LUAD	TCGA	AVTTT	DEG_SPOP_SBC_1	0.1944
p.K143N	DO23562	LUAD	ICGC	AVTTT	DEG_SPOP_SBC_1	0.1944
p.A152D	TCGA-AP-A059	UCEC	TCGA	AVTTT	DEG_SPOP_SBC_1	0.7793
p.A152D	DO41361	UCEC	ICGC	AVTTT	DEG_SPOP_SBC_1	0.7793
p.T145I	DO7250	CLLE	ICGC	AVTTT	DEG_SPOP_SBC_1	0.1389
p.T148S	DO234149	ESAD	ICGC	AVTTT	DEG_SPOP_SBC_1	0.6667
p.R155G	DO233262	GACA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.7568
p.A149S	DO229022	LICA	ICGC	AVTTT	DEG_SPOP_SBC_1	0.25
p.R160W	DO41871	UCEC	ICGC	AVTTT	DEG_SPOP_SBC_1	0.2222
p.L147V	SIDM00961	Ewing's Sarcoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.1944
p.L147V	SIDM01144	Gastric Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.1944
p.L147V	SIDM00247	Gastric Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.1944
p.L147V	SIDM00289	B-Lymphoblastic Leukemia	GDSC	AVTTT	DEG_SPOP_SBC_1	0.1944
p.L147V	SIDM00603	Head and Neck Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.1944
p.L147V	SIDM01659	Kidney Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.1944
p.L147V	SIDM01770	Gastric Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.1944
p.L147V	SIDM01469	Pancreatic Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.1944
p.K146N	SIDM01774	Pancreatic Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	0.2778
p.K146N	ACH-000205	Pancreatic Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	0.2778
p.K146N	ACH-002024	Colon/Colorectal Cancer	CCLE	AVTTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	750:754	AVTTT	SPOP	0.963	More...
O95104	SR-related and CTD-associated factor 4	DEG_SPOP_SBC_1	284:288	AVTTT	SPOP	0.5941	More...
P52756	RNA-binding protein 5	DEG_SPOP_SBC_1	400:404	AVTTT	SPOP	0.6447	More...
Q6Q4G3	Aminopeptidase Q	DEG_SPOP_SBC_1	79:83	AVTTT	SPOP	0.9845	More...
Q86SE5	RNA-binding Raly-like protein	DEG_SPOP_SBC_1	162:166	AVTTT	SPOP	0.9953	More...
Q8IWI9	MAX gene-associated protein	DEG_SPOP_SBC_1	1596:1600	AVTTT	SPOP	0.5077	More...
Q9H3R2	Mucin-13	DEG_SPOP_SBC_1	27:31	AVTTT	SPOP	0.8418	More...
Q9NSU2	Three-prime repair exonuclease 1	DEG_SPOP_SBC_1	247:251	AVTTT	SPOP	0.9952	More...
Q9UKJ1	Paired immunoglobulin-like type 2 receptor alpha	DEG_SPOP_SBC_1	152:156	AVTTT	SPOP	0.5634	More...
Q9Y2H9	Microtubule-associated serine/threonine-protein kinase 1	DEG_SPOP_SBC_1	1048:1052	AVTTT	SPOP	0.8655	More...
Q9UKJ0	Paired immunoglobulin-like type 2 receptor beta	DEG_SPOP_SBC_1	152:156	AVTTT	SPOP	0.7899	More...
A2A368	Melanoma-associated antigen B16	DEG_SPOP_SBC_1	74:78	AVTTT	SPOP	0.5345	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons