DegronMD - Q9Y2H9(MAST1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A84V	TCGA-12-0828	GBM	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.25
p.A84V	TCGA-A6-4105	COAD	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.25
p.A84V	TCGA-D8-A1X7	BRCA	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.25
p.A84V	DO1303	BRCA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.25
p.A84V	DO10670	COAD	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.25
p.A84V	DO12268	GBM	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.25
p.A84V	DO51052	PRAD	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.25
p.R82Q	TCGA-2F-A9KT	BLCA	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1944
p.R82Q	DO51863	BLCA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1944
p.D356V	TCGA-33-4583	LUSC	TCGA	DSGGSNT	DEG_SCF_TRCP1_1	345:351	Mutation rewiring degron network	0.1944
p.D356V	DO27112	LUSC	ICGC	DSGGSNT	DEG_SCF_TRCP1_1	345:351	Mutation rewiring degron network	0.1944
p.S1058F	TCGA-A5-A0G2	UCEC	TCGA	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.1667
p.S1058F	DO41235	UCEC	ICGC	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.1667
p.A1168V	TCGA-A5-A0G2	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation rewiring degron network	0.1944
p.A1168V	DO234401	ESAD	ICGC	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation rewiring degron network	0.1944
p.A1168V	DO41235	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation rewiring degron network	0.1944
p.A1168V	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation rewiring degron network	0.1944
p.A1168V	ACH-000960	Leukemia	CCLE	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation rewiring degron network	0.1944
p.A1168V	REH	haematopoietic and lymphoid tissue	COSMIC	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation rewiring degron network	0.1944
p.A1208T	TCGA-A5-A0GI	UCEC	TCGA	LAHTPSPT	DEG_SCF_FBW7_1	1207:1214	Mutation altering degron motif	0.6028
p.A1208T	DO41807	UCEC	ICGC	LAHTPSPT	DEG_SCF_FBW7_1	1207:1214	Mutation altering degron motif	0.6028
p.S668L	TCGA-A6-6781	COAD	TCGA	FIPHLE	LIG_APCC_ABBA_1	662:667	Mutation rewiring degron network	0.3056
p.S668L	TCGA-E2-A152	BRCA	TCGA	FIPHLE	LIG_APCC_ABBA_1	662:667	Mutation rewiring degron network	0.3056
p.S668L	DO4449	BRCA	ICGC	FIPHLE	LIG_APCC_ABBA_1	662:667	Mutation rewiring degron network	0.3056
p.S668L	DO8447	COAD	ICGC	FIPHLE	LIG_APCC_ABBA_1	662:667	Mutation rewiring degron network	0.3056
p.G1200D	TCGA-AF-2687	READ	TCGA	LAHTPSPT	DEG_SCF_FBW7_1	1207:1214	Mutation rewiring degron network	0.1389
p.G1200D	DO36902	READ	ICGC	LAHTPSPT	DEG_SCF_FBW7_1	1207:1214	Mutation rewiring degron network	0.1389
p.A1152T	TCGA-AX-A2HC	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation rewiring degron network	0.1389
p.A1152T	DO41572	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation rewiring degron network	0.1389
p.V1047E	TCGA-BB-A5HY	HNSC	TCGA	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.3056
p.V1047E	DO218979	HNSC	ICGC	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.3056
p.E1055K	TCGA-BG-A221	UCEC	TCGA	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.25
p.E1055K	TCGA-ND-A4WC	UCS	TCGA	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.25
p.E1055K	DO224642	PACA	ICGC	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.25
p.E1055K	DO42384	UCEC	ICGC	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.25
p.A79D	TCGA-CK-4951	COAD	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1111
p.A79D	DO10582	COAD	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1111
p.S77W	TCGA-CV-7089	HNSC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.0556
p.S77W	DO15158	HNSC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.0556
p.P1159T	TCGA-CV-7091	HNSC	TCGA	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation altering degron motif	0.7031
p.P1159T	DO14212	HNSC	ICGC	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation altering degron motif	0.7031
p.S80F	TCGA-CV-7423	HNSC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1389
p.S80F	DO14246	HNSC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1389
p.S1043N	TCGA-EE-A29L	SKCM	TCGA	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.1944
p.S1043N	DO222599	MELA	ICGC	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.1944
p.S1043N	DO37835	SKCM	ICGC	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.1944
p.N350S	TCGA-EE-A3J5	SKCM	TCGA	DSGGSNT	DEG_SCF_TRCP1_1	345:351	Mutation altering degron motif	0.5958
p.N350S	DO47331	SKCM	ICGC	DSGGSNT	DEG_SCF_TRCP1_1	345:351	Mutation altering degron motif	0.5958
p.L91V	TCGA-EK-A2RJ	CESC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.6765
p.L91V	DO49950	CESC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.6765
p.R753W	TCGA-EO-A3B0	UCEC	TCGA	KREGLGGLT	DEG_APCC_DBOX_1	752:760	Mutation altering degron motif	0.8634
p.R753W	DO219773	UCEC	ICGC	KREGLGGLT	DEG_APCC_DBOX_1	752:760	Mutation altering degron motif	0.8634
p.S90Y	TCGA-FI-A2D5	UCEC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.6009
p.S90Y	DO41331	UCEC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.6009
p.E661K	TCGA-FS-A1ZP	SKCM	TCGA	FIPHLE	LIG_APCC_ABBA_1	662:667	Mutation rewiring degron network	0.3056
p.E661K	DO37703	SKCM	ICGC	FIPHLE	LIG_APCC_ABBA_1	662:667	Mutation rewiring degron network	0.3056
p.A1048P	TCGA-FU-A23K	CESC	TCGA	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation altering degron motif	0.6392
p.A1048P	DO6305	CESC	ICGC	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation altering degron motif	0.6392
p.Q658H	TCGA-G2-AA3D	BLCA	TCGA	FIPHLE	LIG_APCC_ABBA_1	662:667	Mutation rewiring degron network	0.2222
p.Q658H	DO51884	BLCA	ICGC	FIPHLE	LIG_APCC_ABBA_1	662:667	Mutation rewiring degron network	0.2222
p.W89S	TCGA-J9-A52B	PRAD	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.6763
p.W89S	DO51342	PRAD	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.6763
p.G769S	TCGA-T3-A92N	HNSC	TCGA	KREGLGGLT	DEG_APCC_DBOX_1	752:760	Mutation rewiring degron network	0.0833
p.G769S	DO219073	HNSC	ICGC	KREGLGGLT	DEG_APCC_DBOX_1	752:760	Mutation rewiring degron network	0.0833
p.S1161L	TCGA-UY-A9PH	BLCA	TCGA	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation altering degron motif	0.7667
p.S1161L	DO223594	BLCA	ICGC	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation altering degron motif	0.7667
p.D356N	TCGA-YG-AA3P	SKCM	TCGA	DSGGSNT	DEG_SCF_TRCP1_1	345:351	Mutation rewiring degron network	0.1944
p.D356N	DO220891	MELA	ICGC	DSGGSNT	DEG_SCF_TRCP1_1	345:351	Mutation rewiring degron network	0.1944
p.D356N	DO51300	SKCM	ICGC	DSGGSNT	DEG_SCF_TRCP1_1	345:351	Mutation rewiring degron network	0.1944
p.S1172L	TCGA-ZF-AA51	BLCA	TCGA	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation rewiring degron network	0.0833
p.S1172L	DO219093	BLCA	ICGC	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation rewiring degron network	0.0833
p.L341V	DO48425	BLCA	ICGC	DSGGSNT	DEG_SCF_TRCP1_1	345:351	Mutation rewiring degron network	0.2222
p.R1060C	DO225337	BRCA	ICGC	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.1111
p.R1060C	SIDM01263	T-Lymphoblastic Leukemia	GDSC	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.1111
p.P104A	DO224839	BRCA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.0833
p.P104A	DO52549	BRCA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.0833
p.S96L	DO224925	BRCA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.3056
p.S96L	DO227730	BRCA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.3056
p.T1057A	DO233823	GACA	ICGC	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.1944
p.D85Y	DO228986	LICA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.2778
p.A1152S	DO229015	LICA	ICGC	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation rewiring degron network	0.1389
p.A1160S	DO229041	LICA	ICGC	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation altering degron motif	0.6477
p.G348C	DO229045	LICA	ICGC	DSGGSNT	DEG_SCF_TRCP1_1	345:351	Mutation altering degron motif	0.6489
p.S358C	DO230946	LUSC	ICGC	DSGGSNT	DEG_SCF_TRCP1_1	345:351	Mutation rewiring degron network	0.1389
p.S358C	DO224605	LUSC	ICGC	DSGGSNT	DEG_SCF_TRCP1_1	345:351	Mutation rewiring degron network	0.1389
p.P95S	DO222875	MELA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.5641
p.A1171E	DO229234	THCA	ICGC	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation rewiring degron network	0.1111
p.R88W	SIDM01943	Colorectal Carcinoma	GDSC	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation altering degron motif	0.8634
p.R361H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DSGGSNT	DEG_SCF_TRCP1_1	345:351	Mutation rewiring degron network	0.0556
p.R361H	ACH-000995	Leukemia	CCLE	DSGGSNT	DEG_SCF_TRCP1_1	345:351	Mutation rewiring degron network	0.0556
p.R361H	ACH-001061	Colon/Colorectal Cancer	CCLE	DSGGSNT	DEG_SCF_TRCP1_1	345:351	Mutation rewiring degron network	0.0556
p.R361H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DSGGSNT	DEG_SCF_TRCP1_1	345:351	Mutation rewiring degron network	0.0556
p.A1048S	SIDM00629	Breast Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation altering degron motif	0.7588
p.A1048S	SIDM00258	Neuroblastoma	GDSC	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation altering degron motif	0.7588
p.G1062V	SIDM01036	Plasma Cell Myeloma	GDSC	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.0556
p.G1062V	ACH-000653	Myeloma	CCLE	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.0556
p.G1062V	JJN-3	haematopoietic and lymphoid tissue	COSMIC	AVTTT	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.0556
p.A1171T	SIDM00683	Prostate Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation rewiring degron network	0.1111
p.A1171T	ACH-000977	lymph node	CCLE	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation rewiring degron network	0.1111
p.A1171T	LNCaP-Clone-FGC	prostate	COSMIC	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation rewiring degron network	0.1111
p.S346T	SIDM00491	Thyroid Gland Carcinoma	GDSC	DSGGSNT	DEG_SCF_TRCP1_1	345:351	Mutation altering degron motif	0.7116
p.S346T	ACH-001443	Thyroid Cancer	CCLE	DSGGSNT	DEG_SCF_TRCP1_1	345:351	Mutation altering degron motif	0.7116
p.S346T	ASH-3	thyroid	COSMIC	DSGGSNT	DEG_SCF_TRCP1_1	345:351	Mutation altering degron motif	0.7116
p.G744S	SIDM00393	Gastric Carcinoma	GDSC	KREGLGGLT	DEG_APCC_DBOX_1	752:760	Mutation rewiring degron network	0.1111
p.G744S	ACH-001653	Gastric Cancer	CCLE	KREGLGGLT	DEG_APCC_DBOX_1	752:760	Mutation rewiring degron network	0.1111
p.G744S	SK-GT-2	stomach	COSMIC	KREGLGGLT	DEG_APCC_DBOX_1	752:760	Mutation rewiring degron network	0.1111
p.A79T	SIDM00333	Endometrial Carcinoma	GDSC	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1111
p.A79T	ACH-000988	Endometrial/Uterine Cancer	CCLE	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1111
p.A79T	MFE-319	endometrium	COSMIC	RRWSLASLP	DEG_APCC_DBOX_1	87:95	Mutation rewiring degron network	0.1111
p.G1223D	SIDM00487	Colorectal Carcinoma	GDSC	LAHTPSPT	DEG_SCF_FBW7_1	1207:1214	Mutation rewiring degron network	0.0833
p.G1223D	ACH-000963	Colon/Colorectal Cancer	CCLE	LAHTPSPT	DEG_SCF_FBW7_1	1207:1214	Mutation rewiring degron network	0.0833
p.G1223D	CCK-81	large intestine	COSMIC	LAHTPSPT	DEG_SCF_FBW7_1	1207:1214	Mutation rewiring degron network	0.0833
p.S673I	SIDM00145	T-Lymphoblastic Leukemia	GDSC	FIPHLE	LIG_APCC_ABBA_1	662:667	Mutation rewiring degron network	0.1667
p.S673I	ACH-001127	Leukemia	CCLE	FIPHLE	LIG_APCC_ABBA_1	662:667	Mutation rewiring degron network	0.1667
p.S673I	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	FIPHLE	LIG_APCC_ABBA_1	662:667	Mutation rewiring degron network	0.1667
p.Q1155K	ACH-000467	Colon/Colorectal Cancer	CCLE	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation rewiring degron network	0.2222
p.H1173Y	ACH-001127	Leukemia	CCLE	PASST	DEG_SPOP_SBC_1	1159:1163	Mutation rewiring degron network	0.0556
p.L1204V	ACH-001336	Cervical Cancer	CCLE	LAHTPSPT	DEG_SCF_FBW7_1	1207:1214	Mutation rewiring degron network	0.25
p.F662L	ACH-001991	Primary	CCLE	FIPHLE	LIG_APCC_ABBA_1	662:667	Mutation altering degron motif	0.587
p.R357H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DSGGSNT	DEG_SCF_TRCP1_1	345:351	Mutation rewiring degron network	0.1667
p.S342T	ASH-3	thyroid	COSMIC	DSGGSNT	DEG_SCF_TRCP1_1	345:351	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAST1

UniProt ID: Q9Y2H9

Entrez ID: 22983

Protein name: Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAST1 in