DegronMD

Uniprot ID: Q9Y2H9

Source protein: Microtubule-associated serine/threonine-protein kinase 1

Source gene: MAST1

Class: DEG_APCC_DBOX_1

Location: 87:95

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7322

ASA_SCORE: 62.2667

COIL: 0.582

CONS_SCORE: 0.589

DSS_SCORE: 0.4925

HELIX: 0.087

FCONS_SCORE: 1.356

RIG_SCORE: 0.7027

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A84V	TCGA-12-0828	GBM	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.25
p.A84V	TCGA-A6-4105	COAD	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.25
p.A84V	TCGA-D8-A1X7	BRCA	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.25
p.A84V	DO1303	BRCA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.25
p.A84V	DO10670	COAD	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.25
p.A84V	DO12268	GBM	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.25
p.A84V	DO51052	PRAD	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.25
p.R82Q	TCGA-2F-A9KT	BLCA	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.1944
p.R82Q	DO51863	BLCA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.1944
p.A79D	TCGA-CK-4951	COAD	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.1111
p.A79D	DO10582	COAD	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.1111
p.S77W	TCGA-CV-7089	HNSC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.0556
p.S77W	DO15158	HNSC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.0556
p.S80F	TCGA-CV-7423	HNSC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.1389
p.S80F	DO14246	HNSC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.1389
p.L91V	TCGA-EK-A2RJ	CESC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.6765
p.L91V	DO49950	CESC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.6765
p.S90Y	TCGA-FI-A2D5	UCEC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.6009
p.S90Y	DO41331	UCEC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.6009
p.W89S	TCGA-J9-A52B	PRAD	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	0.6763
p.W89S	DO51342	PRAD	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.6763
p.P104A	DO224839	BRCA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.0833
p.P104A	DO52549	BRCA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.0833
p.S96L	DO224925	BRCA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.3056
p.S96L	DO227730	BRCA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.3056
p.D85Y	DO228986	LICA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.2778
p.P95S	DO222875	MELA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	0.5641
p.R88W	SIDM01943	Colorectal Carcinoma	GDSC	RRWSLASLP	DEG_APCC_DBOX_1	0.8634
p.A79T	SIDM00333	Endometrial Carcinoma	GDSC	RRWSLASLP	DEG_APCC_DBOX_1	0.1111
p.A79T	ACH-000988	Endometrial/Uterine Cancer	CCLE	RRWSLASLP	DEG_APCC_DBOX_1	0.1111
p.A79T	MFE-319	endometrium	COSMIC	RRWSLASLP	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15021	Microtubule-associated serine/threonine-protein kinase 4	DEG_APCC_DBOX_1	282:290	RRWSLASLP	APC,CDC20,FZR1	0.9866	More...
O60307	Microtubule-associated serine/threonine-protein kinase 3	DEG_APCC_DBOX_1	82:90	RRWSLASLP	APC,CDC20,FZR1	0.8625	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_APCC_DBOX_1	227:235	RRWSLASLP	APC,CDC20,FZR1	0.978	More...
Q9Y2H9	Microtubule-associated serine/threonine-protein kinase 1	DEG_APCC_DBOX_1	87:95	RRWSLASLP	APC,CDC20,FZR1	0.7322	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRWSLASLP

Degron related mutations and impact score

Drug responses associated with MAST1 mutations

All proteins holding degron of RRWSLASLP