DegronMD - O15021(MAST4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S38L	TCGA-19-4068	GBM	TCGA	AESSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.3056
p.S38L	DO12028	GBM	ICGC	AESSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.3056
p.T1280I	TCGA-49-6743	LUAD	TCGA	SLSSGE	DEG_Kelch_Keap1_1	1290:1295	Mutation rewiring degron network	0.0556
p.R283H	TCGA-56-5897	LUSC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation altering degron motif	0.8244
p.R278W	TCGA-B0-5098	KIRC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation rewiring degron network	0.2222
p.A287D	TCGA-B5-A3FC	UCEC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation altering degron motif	0.6682
p.T1382A	TCGA-BG-A222	UCEC	TCGA	LARTPSPT	DEG_SCF_FBW7_1	1379:1386	Mutation altering degron motif	0.825
p.S1293L	TCGA-CR-6481	HNSC	TCGA	SLSSGE	DEG_Kelch_Keap1_1	1290:1295	Mutation altering degron motif	0.7667
p.S1293L	SIDM00779	Colorectal Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1290:1295	Mutation altering degron motif	0.7667
p.S1293L	ACH-000491	Colon/Colorectal Cancer	CCLE	SLSSGE	DEG_Kelch_Keap1_1	1290:1295	Mutation altering degron motif	0.7667
p.S1293L	NCI-H716	large intestine	COSMIC	SLSSGE	DEG_Kelch_Keap1_1	1290:1295	Mutation altering degron motif	0.7667
p.P1392Q	TCGA-D3-A1Q4	SKCM	TCGA	LARTPSPT	DEG_SCF_FBW7_1	1379:1386	Mutation rewiring degron network	0.1667
p.L1030M	TCGA-D3-A2J8	SKCM	TCGA	VTTPAST	DEG_SCF_FBW7_1	1018:1024	Mutation rewiring degron network	0.1667
p.R278S	TCGA-DD-AACZ	LIHC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation rewiring degron network	0.2222
p.S285W	TCGA-DD-AADV	LIHC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation altering degron motif	0.7874
p.S285W	TCGA-W5-AA2U	CHOL	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation altering degron motif	0.7874
p.P1021Q	TCGA-DU-7298	LGG	TCGA	VTTPAST	DEG_SCF_FBW7_1	1018:1024	Mutation altering degron motif	0.7035
p.P299H	TCGA-DZ-6133	KIRP	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation rewiring degron network	0.0833
p.Q1013K	TCGA-EB-A3XF	SKCM	TCGA	VTTPAST	DEG_SCF_FBW7_1	1018:1024	Mutation rewiring degron network	0.1944
p.W284L	TCGA-EE-A29L	SKCM	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation altering degron motif	0.5904
p.P1301T	TCGA-EE-A29P	SKCM	TCGA	SLSSGE	DEG_Kelch_Keap1_1	1290:1295	Mutation rewiring degron network	0.1667
p.P1387Q	TCGA-ER-A19T	SKCM	TCGA	LARTPSPT	DEG_SCF_FBW7_1	1379:1386	Mutation rewiring degron network	0.3056
p.R1289K	TCGA-F7-8489	HNSC	TCGA	SLSSGE	DEG_Kelch_Keap1_1	1290:1295	Mutation rewiring degron network	0.3056
p.I1374V	TCGA-F7-A624	HNSC	TCGA	LARTPSPT	DEG_SCF_FBW7_1	1379:1386	Mutation rewiring degron network	0.1944
p.E1017K	TCGA-GD-A6C6	BLCA	TCGA	VTTPAST	DEG_SCF_FBW7_1	1018:1024	Mutation rewiring degron network	0.3056
p.P1392L	TCGA-HU-A4GQ	STAD	TCGA	LARTPSPT	DEG_SCF_FBW7_1	1379:1386	Mutation rewiring degron network	0.1667
p.A276S	TCGA-K4-A5RJ	BLCA	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation rewiring degron network	0.1667
p.S1395L	TCGA-UY-A78P	BLCA	TCGA	LARTPSPT	DEG_SCF_FBW7_1	1379:1386	Mutation rewiring degron network	0.0833
p.S274L	TCGA-Z2-A8RT	SKCM	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation rewiring degron network	0.1111
p.S274L	SIDM00527	Colorectal Carcinoma	GDSC	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation rewiring degron network	0.1111
p.S274L	ACH-000935	Colon/Colorectal Cancer	CCLE	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation rewiring degron network	0.1111
p.S274L	MDST8	large intestine	COSMIC	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation rewiring degron network	0.1111
p.W42C	DO445	BLCA	ICGC	AESSS	DEG_SPOP_SBC_1	39:43	Mutation altering degron motif	0.7
p.R299C	DO223732	CESC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation rewiring degron network	0.0833
p.K1286T	DO10324	COAD	ICGC	SLSSGE	DEG_Kelch_Keap1_1	1290:1295	Mutation rewiring degron network	0.2222
p.K292T	DO8400	COAD	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation rewiring degron network	0.2778
p.R45Q	DO8264	COAD	ICGC	AESSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.2778
p.R45Q	DO219917	DLBC	ICGC	AESSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.2778
p.E40K	DO227802	COCA	ICGC	AESSS	DEG_SPOP_SBC_1	39:43	Mutation altering degron motif	0.591
p.R1303Q	DO223025	ESCA	ICGC	SLSSGE	DEG_Kelch_Keap1_1	1290:1295	Mutation rewiring degron network	0.1111
p.S1288N	DO233281	GACA	ICGC	SLSSGE	DEG_Kelch_Keap1_1	1290:1295	Mutation rewiring degron network	0.2778
p.C1283F	DO228978	LICA	ICGC	SLSSGE	DEG_Kelch_Keap1_1	1290:1295	Mutation blocking phosphorylation signal	0.5833
p.G1379W	DO228971	LICA	ICGC	LARTPSPT	DEG_SCF_FBW7_1	1379:1386	Mutation altering degron motif	0.7825
p.D276Y	DO229027	LICA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation rewiring degron network	0.1667
p.I1018M	DO26404	LUAD	ICGC	VTTPAST	DEG_SCF_FBW7_1	1018:1024	Mutation altering degron motif	0.7618
p.A274T	DO25471	LUAD	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation rewiring degron network	0.1111
p.R299L	DO23771	LUAD	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation rewiring degron network	0.0833
p.S37F	DO51494	PACA	ICGC	AESSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.2778
p.R277C	DO42312	UCEC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation rewiring degron network	0.1944
p.E282K	DO41211	UCEC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation altering degron motif	0.7022
p.R278G	SIDM00150	Colorectal Carcinoma	GDSC	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation rewiring degron network	0.2222
p.R278G	KM12	large intestine	COSMIC	RRWSLASLP	DEG_APCC_DBOX_1	282:290	Mutation rewiring degron network	0.2222
p.P1298L	SIDM00150	Colorectal Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1290:1295	Mutation rewiring degron network	0.25
p.P1298L	ACH-000969	Colon/Colorectal Cancer	CCLE	SLSSGE	DEG_Kelch_Keap1_1	1290:1295	Mutation rewiring degron network	0.25
p.P1298L	KM12	large intestine	COSMIC	SLSSGE	DEG_Kelch_Keap1_1	1290:1295	Mutation rewiring degron network	0.25
p.G1372S	SIDM00273	Glioblastoma	GDSC	LARTPSPT	DEG_SCF_FBW7_1	1379:1386	Mutation rewiring degron network	0.1389
p.G1372S	GI-1	central nervous system	COSMIC	LARTPSPT	DEG_SCF_FBW7_1	1379:1386	Mutation rewiring degron network	0.1389
p.P32S	ACH-002314	Leukemia	CCLE	AESSS	DEG_SPOP_SBC_1	39:43	Mutation blocking phosphorylation signal	0.5833
p.P32S	TUR	haematopoietic and lymphoid tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	39:43	Mutation blocking phosphorylation signal	0.5833
p.K1385T	SBC-3	lung	COSMIC	LARTPSPT	DEG_SCF_FBW7_1	1379:1386	Mutation altering degron motif	0.7306
p.K1385T	QGP-1	pancreas	COSMIC	LARTPSPT	DEG_SCF_FBW7_1	1379:1386	Mutation altering degron motif	0.7306
p.E1382K	LNCaP-Clone-FGC	prostate	COSMIC	LARTPSPT	DEG_SCF_FBW7_1	1379:1386	Mutation altering degron motif	0.7022
p.S31R	SNU-C5	large intestine	COSMIC	AESSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1111
p.E1377K	LNCaP-Clone-FGC	prostate	COSMIC	LARTPSPT	DEG_SCF_FBW7_1	1379:1386	Mutation blocking phosphorylation signal	0.7222
p.K1390T	SBC-3	lung	COSMIC	LARTPSPT	DEG_SCF_FBW7_1	1379:1386	Mutation blocking phosphorylation signal	0.6667
p.K1390T	QGP-1	pancreas	COSMIC	LARTPSPT	DEG_SCF_FBW7_1	1379:1386	Mutation blocking phosphorylation signal	0.6667
p.P1389A	NB5	autonomic ganglia	COSMIC	LARTPSPT	DEG_SCF_FBW7_1	1379:1386	Mutation rewiring degron network	0.25
p.S43R	SNU-C5	large intestine	COSMIC	AESSS	DEG_SPOP_SBC_1	39:43	Mutation altering degron motif	0.7427
p.E1392K	LNCaP-Clone-FGC	prostate	COSMIC	LARTPSPT	DEG_SCF_FBW7_1	1379:1386	Mutation rewiring degron network	0.1667
p.P1384A	NB5	autonomic ganglia	COSMIC	LARTPSPT	DEG_SCF_FBW7_1	1379:1386	Mutation altering degron motif	0.7503

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAST4

UniProt ID: O15021

Entrez ID: 375449

Protein name: Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAST4 in