DegronMD

Uniprot ID: O15021

Source protein: Microtubule-associated serine/threonine-protein kinase 4

Source gene: MAST4

Class: DEG_SCF_FBW7_1

Location: 1379:1386

E3 ligase: FBXW7

DEGRON score: 0.9967

ASA_SCORE: 80.0375

COIL: 0.9018

CONS_SCORE: 0.659

DSS_SCORE: 0.8116

HELIX: 0.0448

FCONS_SCORE: 1.1751

RIG_SCORE: 0.556

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1382A	TCGA-BG-A222	UCEC	TCGA	LARTPSPT	DEG_SCF_FBW7_1	0.825
p.P1392Q	TCGA-D3-A1Q4	SKCM	TCGA	LARTPSPT	DEG_SCF_FBW7_1	0.1667
p.P1387Q	TCGA-ER-A19T	SKCM	TCGA	LARTPSPT	DEG_SCF_FBW7_1	0.3056
p.I1374V	TCGA-F7-A624	HNSC	TCGA	LARTPSPT	DEG_SCF_FBW7_1	0.1944
p.P1392L	TCGA-HU-A4GQ	STAD	TCGA	LARTPSPT	DEG_SCF_FBW7_1	0.1667
p.S1395L	TCGA-UY-A78P	BLCA	TCGA	LARTPSPT	DEG_SCF_FBW7_1	0.0833
p.G1379W	DO228971	LICA	ICGC	LARTPSPT	DEG_SCF_FBW7_1	0.7825
p.G1372S	SIDM00273	Glioblastoma	GDSC	LARTPSPT	DEG_SCF_FBW7_1	0.1389
p.G1372S	GI-1	central_nervous_system	COSMIC	LARTPSPT	DEG_SCF_FBW7_1	0.1389
p.K1385T	SBC-3	lung	COSMIC	LARTPSPT	DEG_SCF_FBW7_1	0.7306
p.K1385T	QGP-1	pancreas	COSMIC	LARTPSPT	DEG_SCF_FBW7_1	0.7306
p.E1382K	LNCaP-Clone-FGC	prostate	COSMIC	LARTPSPT	DEG_SCF_FBW7_1	0.7022
p.E1377K	LNCaP-Clone-FGC	prostate	COSMIC	LARTPSPT	DEG_SCF_FBW7_1	0.7222
p.K1390T	SBC-3	lung	COSMIC	LARTPSPT	DEG_SCF_FBW7_1	0.6667
p.K1390T	QGP-1	pancreas	COSMIC	LARTPSPT	DEG_SCF_FBW7_1	0.6667
p.P1389A	NB5	autonomic_ganglia	COSMIC	LARTPSPT	DEG_SCF_FBW7_1	0.25
p.E1392K	LNCaP-Clone-FGC	prostate	COSMIC	LARTPSPT	DEG_SCF_FBW7_1	0.1667
p.P1384A	NB5	autonomic_ganglia	COSMIC	LARTPSPT	DEG_SCF_FBW7_1	0.7503

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15021	Microtubule-associated serine/threonine-protein kinase 4	DEG_SCF_FBW7_1	1379:1386	LARTPSPT	FBXW7	0.9967	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons