DegronMD

Uniprot ID: O15021

Source protein: Microtubule-associated serine/threonine-protein kinase 4

Source gene: MAST4

Class: DEG_Kelch_Keap1_1

Location: 1290:1295

E3 ligase: KEAP1

DEGRON score: 0.9965

ASA_SCORE: 80.5833

COIL: 0.898

CONS_SCORE: 0.4208

DSS_SCORE: 0.5157

HELIX: 0.0465

FCONS_SCORE: 0.8977

RIG_SCORE: 0.5635

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1280I	TCGA-49-6743	LUAD	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.0556
p.S1293L	TCGA-CR-6481	HNSC	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.7667
p.S1293L	SIDM00779	Colorectal Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.7667
p.S1293L	ACH-000491	Colon/Colorectal Cancer	CCLE	SLSSGE	DEG_Kelch_Keap1_1	0.7667
p.S1293L	NCI-H716	large_intestine	COSMIC	SLSSGE	DEG_Kelch_Keap1_1	0.7667
p.P1301T	TCGA-EE-A29P	SKCM	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.1667
p.R1289K	TCGA-F7-8489	HNSC	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.3056
p.K1286T	DO10324	COAD	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.2222
p.R1303Q	DO223025	ESCA	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.1111
p.S1288N	DO233281	GACA	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.2778
p.C1283F	DO228978	LICA	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.5833
p.P1298L	SIDM00150	Colorectal Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.25
p.P1298L	ACH-000969	Colon/Colorectal Cancer	CCLE	SLSSGE	DEG_Kelch_Keap1_1	0.25
p.P1298L	KM12	large_intestine	COSMIC	SLSSGE	DEG_Kelch_Keap1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15021	Microtubule-associated serine/threonine-protein kinase 4	DEG_Kelch_Keap1_1	1290:1295	SLSSGE	KEAP1	0.9965	More...
P04150	Glucocorticoid receptor	DEG_Kelch_Keap1_1	111:116	SLSSGE	KEAP1	0.6996	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_Kelch_Keap1_1	1254:1259	SLSSGE	KEAP1	0.9967	More...
Q8IY81	pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3	DEG_Kelch_Keap1_1	333:338	SLSSGE	KEAP1	0.9727	More...
Q8TDX9	Polycystic kidney disease protein 1-like 1	DEG_Kelch_Keap1_1	1160:1165	SLSSGE	KEAP1	0.6964	More...
Q6P3S6	F-box only protein 42	DEG_Kelch_Keap1_1	592:597	SLSSGE	KEAP1	0.9619	More...
Q96BV0	Zinc finger protein 775	DEG_Kelch_Keap1_1	99:104	SLSSGE	KEAP1	0.7671	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons