DegronMD - Q8TDX9(PKD1L1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S228I	TCGA-44-6777	LUAD	TCGA	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.2778
p.S228I	DO23645	LUAD	ICGC	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.2778
p.E1165K	TCGA-56-8308	LUSC	TCGA	SLSSGE	DEG_Kelch_Keap1_1	1160:1165	Mutation altering degron motif	0.7022
p.E1165K	DO219140	LUSC	ICGC	SLSSGE	DEG_Kelch_Keap1_1	1160:1165	Mutation altering degron motif	0.7022
p.S246I	TCGA-69-A59K	LUAD	TCGA	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.1111
p.S246I	TCGA-69-A59K	LUAD	TCGA	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation rewiring degron network	0.1111
p.S246I	DO45335	LUAD	ICGC	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.1111
p.S246I	DO45335	LUAD	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation rewiring degron network	0.1111
p.Q226L	TCGA-75-7031	LUAD	TCGA	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.2222
p.Q226L	DO25545	LUAD	ICGC	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.2222
p.R256H	TCGA-AA-3666	COAD	TCGA	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation altering degron motif	0.7133
p.R256H	DO9042	COAD	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation altering degron motif	0.7133
p.G249S	TCGA-AA-3713	COAD	TCGA	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation rewiring degron network	0.1944
p.G249S	TCGA-ER-A193	SKCM	TCGA	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation rewiring degron network	0.1944
p.G249S	DO8400	COAD	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation rewiring degron network	0.1944
p.G249S	DO47368	SKCM	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation rewiring degron network	0.1944
p.L1161R	TCGA-AA-3966	COAD	TCGA	SLSSGE	DEG_Kelch_Keap1_1	1160:1165	Mutation altering degron motif	0.7316
p.L1161R	DO10068	COAD	ICGC	SLSSGE	DEG_Kelch_Keap1_1	1160:1165	Mutation altering degron motif	0.7316
p.S1175L	TCGA-AA-A02R	COAD	TCGA	SLSSGE	DEG_Kelch_Keap1_1	1160:1165	Mutation rewiring degron network	0.0556
p.S1175L	TCGA-DF-A2KU	UCEC	TCGA	SLSSGE	DEG_Kelch_Keap1_1	1160:1165	Mutation rewiring degron network	0.0556
p.S1175L	DO223286	UCEC	ICGC	SLSSGE	DEG_Kelch_Keap1_1	1160:1165	Mutation rewiring degron network	0.0556
p.T2767I	TCGA-AX-A0IU	UCEC	TCGA	LETPKLE	DEG_SCF_FBW7_2	2771:2777	Mutation rewiring degron network	0.2222
p.T2767I	DO40954	UCEC	ICGC	LETPKLE	DEG_SCF_FBW7_2	2771:2777	Mutation rewiring degron network	0.2222
p.T1155A	TCGA-CV-7411	HNSC	TCGA	SLSSGE	DEG_Kelch_Keap1_1	1160:1165	Mutation rewiring degron network	0.1944
p.T1155A	DO15142	HNSC	ICGC	SLSSGE	DEG_Kelch_Keap1_1	1160:1165	Mutation rewiring degron network	0.1944
p.P241S	TCGA-D3-A8GC	SKCM	TCGA	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.25
p.P241S	DO50281	SKCM	ICGC	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.25
p.Q230L	TCGA-D6-A4ZB	HNSC	TCGA	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation altering degron motif	0.6654
p.Q230L	DO44446	HNSC	ICGC	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation altering degron motif	0.6654
p.G249C	TCGA-DA-A1IB	SKCM	TCGA	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation rewiring degron network	0.1944
p.G249C	DO38033	SKCM	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation rewiring degron network	0.1944
p.E2763K	TCGA-EE-A2GJ	SKCM	TCGA	LETPKLE	DEG_SCF_FBW7_2	2771:2777	Mutation rewiring degron network	0.1111
p.E2763K	TCGA-QB-A6FS	SKCM	TCGA	LETPKLE	DEG_SCF_FBW7_2	2771:2777	Mutation rewiring degron network	0.1111
p.E2763K	DO37746	SKCM	ICGC	LETPKLE	DEG_SCF_FBW7_2	2771:2777	Mutation rewiring degron network	0.1111
p.E2763K	DO48654	SKCM	ICGC	LETPKLE	DEG_SCF_FBW7_2	2771:2777	Mutation rewiring degron network	0.1111
p.A2779T	TCGA-EE-A3JD	SKCM	TCGA	LETPKLE	DEG_SCF_FBW7_2	2771:2777	Mutation rewiring degron network	0.2778
p.A2779T	DO50299	SKCM	ICGC	LETPKLE	DEG_SCF_FBW7_2	2771:2777	Mutation rewiring degron network	0.2778
p.T1166M	TCGA-EJ-AB27	PRAD	TCGA	SLSSGE	DEG_Kelch_Keap1_1	1160:1165	Mutation rewiring degron network	0.3056
p.T1166M	DO51336	PRAD	ICGC	SLSSGE	DEG_Kelch_Keap1_1	1160:1165	Mutation rewiring degron network	0.3056
p.H239Y	TCGA-EO-A22R	UCEC	TCGA	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.3056
p.H239Y	DO42713	UCEC	ICGC	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.3056
p.P236L	TCGA-GF-A3OT	SKCM	TCGA	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation altering degron motif	0.6471
p.P236L	DO47288	SKCM	ICGC	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation altering degron motif	0.6471
p.P236L	SIDM01060	Melanoma	GDSC	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation altering degron motif	0.6471
p.P236L	IGR-1	skin	COSMIC	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation altering degron motif	0.6471
p.T1150I	TCGA-HU-8602	STAD	TCGA	SLSSGE	DEG_Kelch_Keap1_1	1160:1165	Mutation rewiring degron network	0.0556
p.T1150I	DO47829	STAD	ICGC	SLSSGE	DEG_Kelch_Keap1_1	1160:1165	Mutation rewiring degron network	0.0556
p.Y1167N	TCGA-NC-A5HT	LUSC	TCGA	SLSSGE	DEG_Kelch_Keap1_1	1160:1165	Mutation rewiring degron network	0.2778
p.Y1167N	DO219205	LUSC	ICGC	SLSSGE	DEG_Kelch_Keap1_1	1160:1165	Mutation rewiring degron network	0.2778
p.S265Y	TCGA-RR-A6KA	GBM	TCGA	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation rewiring degron network	0.2222
p.S265Y	DO51167	GBM	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation rewiring degron network	0.2222
p.P251L	TCGA-UC-A7PG	CESC	TCGA	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation rewiring degron network	0.25
p.P251L	DO51615	CESC	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation rewiring degron network	0.25
p.A2779V	TCGA-XK-AAIW	PRAD	TCGA	LETPKLE	DEG_SCF_FBW7_2	2771:2777	Mutation rewiring degron network	0.2778
p.A2779V	DO51407	PRAD	ICGC	LETPKLE	DEG_SCF_FBW7_2	2771:2777	Mutation rewiring degron network	0.2778
p.V1171L	TCGA-YL-A9WH	PRAD	TCGA	SLSSGE	DEG_Kelch_Keap1_1	1160:1165	Mutation rewiring degron network	0.1667
p.V1171L	DO51440	PRAD	ICGC	SLSSGE	DEG_Kelch_Keap1_1	1160:1165	Mutation rewiring degron network	0.1667
p.R245K	DO48398	BLCA	ICGC	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.1389
p.R245K	DO48398	BLCA	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation rewiring degron network	0.0833
p.W2762L	DO5745	BRCA	ICGC	LETPKLE	DEG_SCF_FBW7_2	2771:2777	Mutation rewiring degron network	0.0833
p.V2765I	DO227646	COCA	ICGC	LETPKLE	DEG_SCF_FBW7_2	2771:2777	Mutation rewiring degron network	0.1667
p.P2774Q	DO228986	LICA	ICGC	LETPKLE	DEG_SCF_FBW7_2	2771:2777	Mutation altering degron motif	0.7035
p.S228R	DO229019	LICA	ICGC	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.2778
p.T1155K	DO229036	LICA	ICGC	SLSSGE	DEG_Kelch_Keap1_1	1160:1165	Mutation rewiring degron network	0.1944
p.H248Q	DO229008	LICA	ICGC	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.0556
p.H248Q	DO229008	LICA	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation rewiring degron network	0.1667
p.Y271H	DO23513	LIRI	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation rewiring degron network	0.0556
p.R256C	DO229465	SKCA	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation altering degron motif	0.719
p.T1155R	SIDM00041	Gastric Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1160:1165	Mutation rewiring degron network	0.1944
p.T1155R	STS-0421	soft tissue	COSMIC	SLSSGE	DEG_Kelch_Keap1_1	1160:1165	Mutation rewiring degron network	0.1944
p.G253V	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation rewiring degron network	0.3056
p.G253V	ACH-000021	Lung Cancer	CCLE	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation rewiring degron network	0.3056
p.G253V	NCI-H1693	lung	COSMIC	IPRTPSFT	DEG_SCF_FBW7_1	254:261	Mutation rewiring degron network	0.3056
p.T227N	SIDM00327	Hodgkin's Lymphoma	GDSC	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.25
p.T227N	ACH-000754	Lymphoma	CCLE	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.25
p.T227N	L-428	haematopoietic and lymphoid tissue	COSMIC	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.25
p.A222V	SIDM01088	Endometrial Carcinoma	GDSC	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.1111
p.A222V	ACH-000965	Endometrial/Uterine Cancer	CCLE	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.1111
p.A222V	RL95-2	endometrium	COSMIC	QRVPLWPIS	DEG_APCC_DBOX_1	230:238	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PKD1L1

UniProt ID: Q8TDX9

Entrez ID: 168507

Protein name: Polycystic kidney disease protein 1-like 1 (PC1-like 1 protein) (Polycystin-1L1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PKD1L1 in