DegronMD

Uniprot ID: Q8TDX9

Source protein: Polycystic kidney disease protein 1-like 1

Source gene: PKD1L1

Class: DEG_SCF_FBW7_2

Location: 2771:2777

E3 ligase: FBXW7

DEGRON score: 0.5829

ASA_SCORE: 100.9429

COIL: 0.7677

CONS_SCORE: 0.5135

DSS_SCORE: 0.1166

HELIX: 0.2186

FCONS_SCORE: 1.4565

RIG_SCORE: 0.8499

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2767I	TCGA-AX-A0IU	UCEC	TCGA	LETPKLE	DEG_SCF_FBW7_2	0.2222
p.T2767I	DO40954	UCEC	ICGC	LETPKLE	DEG_SCF_FBW7_2	0.2222
p.E2763K	TCGA-EE-A2GJ	SKCM	TCGA	LETPKLE	DEG_SCF_FBW7_2	0.1111
p.E2763K	TCGA-QB-A6FS	SKCM	TCGA	LETPKLE	DEG_SCF_FBW7_2	0.1111
p.E2763K	DO37746	SKCM	ICGC	LETPKLE	DEG_SCF_FBW7_2	0.1111
p.E2763K	DO48654	SKCM	ICGC	LETPKLE	DEG_SCF_FBW7_2	0.1111
p.A2779T	TCGA-EE-A3JD	SKCM	TCGA	LETPKLE	DEG_SCF_FBW7_2	0.2778
p.A2779T	DO50299	SKCM	ICGC	LETPKLE	DEG_SCF_FBW7_2	0.2778
p.A2779V	TCGA-XK-AAIW	PRAD	TCGA	LETPKLE	DEG_SCF_FBW7_2	0.2778
p.A2779V	DO51407	PRAD	ICGC	LETPKLE	DEG_SCF_FBW7_2	0.2778
p.W2762L	DO5745	BRCA	ICGC	LETPKLE	DEG_SCF_FBW7_2	0.0833
p.V2765I	DO227646	COCA	ICGC	LETPKLE	DEG_SCF_FBW7_2	0.1667
p.P2774Q	DO228986	LICA	ICGC	LETPKLE	DEG_SCF_FBW7_2	0.7035

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDX9	Polycystic kidney disease protein 1-like 1	DEG_SCF_FBW7_2	2771:2777	LETPKLE	FBXW7	0.5829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons