DegronMD

Uniprot ID: Q8TDX9

Source protein: Polycystic kidney disease protein 1-like 1

Source gene: PKD1L1

Class: DEG_SCF_FBW7_1

Location: 254:261

E3 ligase: FBXW7

DEGRON score: 0.9612

ASA_SCORE: 52.825

COIL: 0.6655

CONS_SCORE: 0.5647

DSS_SCORE: 0.6644

HELIX: 0.023

FCONS_SCORE: 1.0494

RIG_SCORE: 0.6236

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S246I	TCGA-69-A59K	LUAD	TCGA	IPRTPSFT	DEG_SCF_FBW7_1	0.1111
p.S246I	DO45335	LUAD	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	0.1111
p.R256H	TCGA-AA-3666	COAD	TCGA	IPRTPSFT	DEG_SCF_FBW7_1	0.7133
p.R256H	DO9042	COAD	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	0.7133
p.G249S	TCGA-AA-3713	COAD	TCGA	IPRTPSFT	DEG_SCF_FBW7_1	0.1944
p.G249S	TCGA-ER-A193	SKCM	TCGA	IPRTPSFT	DEG_SCF_FBW7_1	0.1944
p.G249S	DO8400	COAD	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	0.1944
p.G249S	DO47368	SKCM	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	0.1944
p.G249C	TCGA-DA-A1IB	SKCM	TCGA	IPRTPSFT	DEG_SCF_FBW7_1	0.1944
p.G249C	DO38033	SKCM	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	0.1944
p.S265Y	TCGA-RR-A6KA	GBM	TCGA	IPRTPSFT	DEG_SCF_FBW7_1	0.2222
p.S265Y	DO51167	GBM	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	0.2222
p.P251L	TCGA-UC-A7PG	CESC	TCGA	IPRTPSFT	DEG_SCF_FBW7_1	0.25
p.P251L	DO51615	CESC	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	0.25
p.R245K	DO48398	BLCA	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	0.0833
p.H248Q	DO229008	LICA	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	0.1667
p.Y271H	DO23513	LIRI	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	0.0556
p.R256C	DO229465	SKCA	ICGC	IPRTPSFT	DEG_SCF_FBW7_1	0.719
p.G253V	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	IPRTPSFT	DEG_SCF_FBW7_1	0.3056
p.G253V	ACH-000021	Lung Cancer	CCLE	IPRTPSFT	DEG_SCF_FBW7_1	0.3056
p.G253V	NCI-H1693	lung	COSMIC	IPRTPSFT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDX9	Polycystic kidney disease protein 1-like 1	DEG_SCF_FBW7_1	254:261	IPRTPSFT	FBXW7	0.9612	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons