DegronMD

Uniprot ID: Q8TDX9

Source protein: Polycystic kidney disease protein 1-like 1

Source gene: PKD1L1

Class: DEG_APCC_DBOX_1

Location: 230:238

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9976

ASA_SCORE: 70.4889

COIL: 0.7483

CONS_SCORE: 0.4703

DSS_SCORE: 0.583

HELIX: 0.0343

FCONS_SCORE: 0.8192

RIG_SCORE: 0.7166

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S228I	TCGA-44-6777	LUAD	TCGA	QRVPLWPIS	DEG_APCC_DBOX_1	0.2778
p.S228I	DO23645	LUAD	ICGC	QRVPLWPIS	DEG_APCC_DBOX_1	0.2778
p.S246I	TCGA-69-A59K	LUAD	TCGA	QRVPLWPIS	DEG_APCC_DBOX_1	0.1111
p.S246I	DO45335	LUAD	ICGC	QRVPLWPIS	DEG_APCC_DBOX_1	0.1111
p.Q226L	TCGA-75-7031	LUAD	TCGA	QRVPLWPIS	DEG_APCC_DBOX_1	0.2222
p.Q226L	DO25545	LUAD	ICGC	QRVPLWPIS	DEG_APCC_DBOX_1	0.2222
p.P241S	TCGA-D3-A8GC	SKCM	TCGA	QRVPLWPIS	DEG_APCC_DBOX_1	0.25
p.P241S	DO50281	SKCM	ICGC	QRVPLWPIS	DEG_APCC_DBOX_1	0.25
p.Q230L	TCGA-D6-A4ZB	HNSC	TCGA	QRVPLWPIS	DEG_APCC_DBOX_1	0.6654
p.Q230L	DO44446	HNSC	ICGC	QRVPLWPIS	DEG_APCC_DBOX_1	0.6654
p.H239Y	TCGA-EO-A22R	UCEC	TCGA	QRVPLWPIS	DEG_APCC_DBOX_1	0.3056
p.H239Y	DO42713	UCEC	ICGC	QRVPLWPIS	DEG_APCC_DBOX_1	0.3056
p.P236L	TCGA-GF-A3OT	SKCM	TCGA	QRVPLWPIS	DEG_APCC_DBOX_1	0.6471
p.P236L	DO47288	SKCM	ICGC	QRVPLWPIS	DEG_APCC_DBOX_1	0.6471
p.P236L	SIDM01060	Melanoma	GDSC	QRVPLWPIS	DEG_APCC_DBOX_1	0.6471
p.P236L	IGR-1	skin	COSMIC	QRVPLWPIS	DEG_APCC_DBOX_1	0.6471
p.R245K	DO48398	BLCA	ICGC	QRVPLWPIS	DEG_APCC_DBOX_1	0.1389
p.S228R	DO229019	LICA	ICGC	QRVPLWPIS	DEG_APCC_DBOX_1	0.2778
p.H248Q	DO229008	LICA	ICGC	QRVPLWPIS	DEG_APCC_DBOX_1	0.0556
p.T227N	SIDM00327	Hodgkin's Lymphoma	GDSC	QRVPLWPIS	DEG_APCC_DBOX_1	0.25
p.T227N	ACH-000754	Lymphoma	CCLE	QRVPLWPIS	DEG_APCC_DBOX_1	0.25
p.T227N	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	QRVPLWPIS	DEG_APCC_DBOX_1	0.25
p.A222V	SIDM01088	Endometrial Carcinoma	GDSC	QRVPLWPIS	DEG_APCC_DBOX_1	0.1111
p.A222V	ACH-000965	Endometrial/Uterine Cancer	CCLE	QRVPLWPIS	DEG_APCC_DBOX_1	0.1111
p.A222V	RL95-2	endometrium	COSMIC	QRVPLWPIS	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDX9	Polycystic kidney disease protein 1-like 1	DEG_APCC_DBOX_1	230:238	QRVPLWPIS	APC,CDC20,FZR1	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRVPLWPIS

Degron related mutations and impact score

Drug responses associated with PKD1L1 mutations

All proteins holding degron of QRVPLWPIS