DegronMD

Uniprot ID: Q8TDX9

Source protein: Polycystic kidney disease protein 1-like 1

Source gene: PKD1L1

Class: DEG_Kelch_Keap1_1

Location: 1160:1165

E3 ligase: KEAP1

DEGRON score: 0.6964

ASA_SCORE: 49.5

COIL: 0.8422

CONS_SCORE: 0.6158

DSS_SCORE: 0.1436

HELIX: 0.01

FCONS_SCORE: 1.1701

RIG_SCORE: 0.7516

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1165K	TCGA-56-8308	LUSC	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.7022
p.E1165K	DO219140	LUSC	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.7022
p.L1161R	TCGA-AA-3966	COAD	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.7316
p.L1161R	DO10068	COAD	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.7316
p.S1175L	TCGA-AA-A02R	COAD	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.0556
p.S1175L	TCGA-DF-A2KU	UCEC	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.0556
p.S1175L	DO223286	UCEC	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.0556
p.T1155A	TCGA-CV-7411	HNSC	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.1944
p.T1155A	DO15142	HNSC	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.1944
p.T1166M	TCGA-EJ-AB27	PRAD	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.3056
p.T1166M	DO51336	PRAD	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.3056
p.T1150I	TCGA-HU-8602	STAD	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.0556
p.T1150I	DO47829	STAD	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.0556
p.Y1167N	TCGA-NC-A5HT	LUSC	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.2778
p.Y1167N	DO219205	LUSC	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.2778
p.V1171L	TCGA-YL-A9WH	PRAD	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.1667
p.V1171L	DO51440	PRAD	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.1667
p.T1155K	DO229036	LICA	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.1944
p.T1155R	SIDM00041	Gastric Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1944
p.T1155R	STS-0421	soft_tissue	COSMIC	SLSSGE	DEG_Kelch_Keap1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15021	Microtubule-associated serine/threonine-protein kinase 4	DEG_Kelch_Keap1_1	1290:1295	SLSSGE	KEAP1	0.9965	More...
P04150	Glucocorticoid receptor	DEG_Kelch_Keap1_1	111:116	SLSSGE	KEAP1	0.6996	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_Kelch_Keap1_1	1254:1259	SLSSGE	KEAP1	0.9967	More...
Q8IY81	pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3	DEG_Kelch_Keap1_1	333:338	SLSSGE	KEAP1	0.9727	More...
Q8TDX9	Polycystic kidney disease protein 1-like 1	DEG_Kelch_Keap1_1	1160:1165	SLSSGE	KEAP1	0.6964	More...
Q6P3S6	F-box only protein 42	DEG_Kelch_Keap1_1	592:597	SLSSGE	KEAP1	0.9619	More...
Q96BV0	Zinc finger protein 775	DEG_Kelch_Keap1_1	99:104	SLSSGE	KEAP1	0.7671	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons