DegronMD - Q6P3S6(FBXO42)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I563M	TCGA-21-5782	LUSC	TCGA	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.6507
p.I563M	TCGA-EK-A3GK	CESC	TCGA	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.6507
p.I563M	DO49964	CESC	ICGC	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.6507
p.I563M	DO27120	LUSC	ICGC	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.6507
p.S572L	TCGA-C5-A7X8	CESC	TCGA	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.1111
p.S572L	TCGA-GU-A42P	BLCA	TCGA	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.1111
p.S572L	TCGA-HD-8635	HNSC	TCGA	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.1111
p.S572L	DO534	BLCA	ICGC	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.1111
p.S572L	DO49895	CESC	ICGC	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.1111
p.S572L	DO14574	HNSC	ICGC	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.1111
p.S552F	TCGA-D3-A2JN	SKCM	TCGA	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation blocking phosphorylation signal	0.6667
p.S552F	DO47590	SKCM	ICGC	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation blocking phosphorylation signal	0.6667
p.A550V	TCGA-EB-A41A	SKCM	TCGA	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.1667
p.A550V	DO37429	SKCM	ICGC	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.1667
p.P508S	TCGA-EE-A2GE	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	508:512	Mutation altering degron motif	0.6752
p.P508S	DO38016	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	508:512	Mutation altering degron motif	0.6752
p.P585T	TCGA-EE-A2MM	SKCM	TCGA	SLSSGE	DEG_Kelch_Keap1_1	592:597	Mutation rewiring degron network	0.1389
p.P585T	DO37770	SKCM	ICGC	SLSSGE	DEG_Kelch_Keap1_1	592:597	Mutation rewiring degron network	0.1389
p.R603C	TCGA-FR-A726	SKCM	TCGA	SLSSGE	DEG_Kelch_Keap1_1	592:597	Mutation rewiring degron network	0.1667
p.R603C	DO48665	SKCM	ICGC	SLSSGE	DEG_Kelch_Keap1_1	592:597	Mutation rewiring degron network	0.1667
p.R603C	SIDM01059	Melanoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	592:597	Mutation rewiring degron network	0.1667
p.R603C	ACH-000915	Skin Cancer	CCLE	SLSSGE	DEG_Kelch_Keap1_1	592:597	Mutation rewiring degron network	0.1667
p.R603C	IPC-298	skin	COSMIC	SLSSGE	DEG_Kelch_Keap1_1	592:597	Mutation rewiring degron network	0.1667
p.G596E	TCGA-FS-A1ZK	SKCM	TCGA	SLSSGE	DEG_Kelch_Keap1_1	592:597	Mutation altering degron motif	0.7199
p.G596E	DO37474	SKCM	ICGC	SLSSGE	DEG_Kelch_Keap1_1	592:597	Mutation altering degron motif	0.7199
p.S510F	TCGA-J4-A67R	PRAD	TCGA	PASSS	DEG_SPOP_SBC_1	508:512	Mutation altering degron motif	0.7982
p.S510F	DO49832	PRAD	ICGC	PASSS	DEG_SPOP_SBC_1	508:512	Mutation altering degron motif	0.7982
p.P553S	TCGA-QB-AA9O	SKCM	TCGA	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.25
p.P553S	DO51267	SKCM	ICGC	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.25
p.A565V	DO222389	BTCA	ICGC	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.3056
p.A509T	DO229010	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	508:512	Mutation altering degron motif	0.6028
p.A509T	DO229013	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	508:512	Mutation altering degron motif	0.6028
p.A509T	DO229016	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	508:512	Mutation altering degron motif	0.6028
p.A509T	DO234285	ESAD	ICGC	PASSS	DEG_SPOP_SBC_1	508:512	Mutation altering degron motif	0.6028
p.A509T	DO52365	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	508:512	Mutation altering degron motif	0.6028
p.A555T	DO233088	GACA	ICGC	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.3056
p.M518I	DO233634	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.1667
p.P508A	DO231974	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	508:512	Mutation altering degron motif	0.6392
p.N513T	DO45115	LIRI	ICGC	PASSS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.3056
p.S499F	DO222843	MELA	ICGC	PASSS	DEG_SPOP_SBC_1	508:512	Mutation rewiring degron network	0.0833
p.P604S	SIDM01175	Other Sarcomas	GDSC	SLSSGE	DEG_Kelch_Keap1_1	592:597	Mutation rewiring degron network	0.1389
p.P604S	ACH-002309	Sarcoma	CCLE	SLSSGE	DEG_Kelch_Keap1_1	592:597	Mutation rewiring degron network	0.1389
p.P604S	SW684	soft tissue	COSMIC	SLSSGE	DEG_Kelch_Keap1_1	592:597	Mutation rewiring degron network	0.1389
p.E561K	SIDM00632	Non-Cancerous	GDSC	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.591
p.E561K	ACH-002247	Non-Cancerous	CCLE	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.591
p.E561K	IM-9	haematopoietic and lymphoid tissue	COSMIC	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation altering degron motif	0.591
p.G589V	SIDM00217	Colorectal Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	592:597	Mutation rewiring degron network	0.25
p.G589V	ACH-000999	Colon/Colorectal Cancer	CCLE	SLSSGE	DEG_Kelch_Keap1_1	592:597	Mutation rewiring degron network	0.25
p.G589V	SNU-1040	large intestine	COSMIC	SLSSGE	DEG_Kelch_Keap1_1	592:597	Mutation rewiring degron network	0.25
p.S568F	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.2222
p.S568F	ACH-002222	Leukemia	CCLE	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.2222
p.S568F	CTV-1	haematopoietic and lymphoid tissue	COSMIC	LRRSLEAIK	DEG_APCC_DBOX_1	556:564	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FBXO42

UniProt ID: Q6P3S6

Entrez ID: 54455

Protein name: F-box only protein 42 (Just one F-box and Kelch domain-containing protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FBXO42 in