DegronMD

Uniprot ID: Q6P3S6

Source protein: F-box only protein 42

Source gene: FBXO42

Class: DEG_APCC_DBOX_1

Location: 556:564

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9251

ASA_SCORE: 93.7556

COIL: 0.3002

CONS_SCORE: 0.4028

DSS_SCORE: 0.4802

HELIX: 0.6877

FCONS_SCORE: 1.1315

RIG_SCORE: 0.7595

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I563M	TCGA-21-5782	LUSC	TCGA	LRRSLEAIK	DEG_APCC_DBOX_1	0.6507
p.I563M	TCGA-EK-A3GK	CESC	TCGA	LRRSLEAIK	DEG_APCC_DBOX_1	0.6507
p.I563M	DO49964	CESC	ICGC	LRRSLEAIK	DEG_APCC_DBOX_1	0.6507
p.I563M	DO27120	LUSC	ICGC	LRRSLEAIK	DEG_APCC_DBOX_1	0.6507
p.S572L	TCGA-C5-A7X8	CESC	TCGA	LRRSLEAIK	DEG_APCC_DBOX_1	0.1111
p.S572L	TCGA-GU-A42P	BLCA	TCGA	LRRSLEAIK	DEG_APCC_DBOX_1	0.1111
p.S572L	TCGA-HD-8635	HNSC	TCGA	LRRSLEAIK	DEG_APCC_DBOX_1	0.1111
p.S572L	DO534	BLCA	ICGC	LRRSLEAIK	DEG_APCC_DBOX_1	0.1111
p.S572L	DO49895	CESC	ICGC	LRRSLEAIK	DEG_APCC_DBOX_1	0.1111
p.S572L	DO14574	HNSC	ICGC	LRRSLEAIK	DEG_APCC_DBOX_1	0.1111
p.S552F	TCGA-D3-A2JN	SKCM	TCGA	LRRSLEAIK	DEG_APCC_DBOX_1	0.6667
p.S552F	DO47590	SKCM	ICGC	LRRSLEAIK	DEG_APCC_DBOX_1	0.6667
p.A550V	TCGA-EB-A41A	SKCM	TCGA	LRRSLEAIK	DEG_APCC_DBOX_1	0.1667
p.A550V	DO37429	SKCM	ICGC	LRRSLEAIK	DEG_APCC_DBOX_1	0.1667
p.P553S	TCGA-QB-AA9O	SKCM	TCGA	LRRSLEAIK	DEG_APCC_DBOX_1	0.25
p.P553S	DO51267	SKCM	ICGC	LRRSLEAIK	DEG_APCC_DBOX_1	0.25
p.A565V	DO222389	BTCA	ICGC	LRRSLEAIK	DEG_APCC_DBOX_1	0.3056
p.A555T	DO233088	GACA	ICGC	LRRSLEAIK	DEG_APCC_DBOX_1	0.3056
p.E561K	SIDM00632	Non-Cancerous	GDSC	LRRSLEAIK	DEG_APCC_DBOX_1	0.591
p.E561K	ACH-002247	Non-Cancerous	CCLE	LRRSLEAIK	DEG_APCC_DBOX_1	0.591
p.E561K	IM-9	haematopoietic_and_lymphoid_tissue	COSMIC	LRRSLEAIK	DEG_APCC_DBOX_1	0.591
p.S568F	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LRRSLEAIK	DEG_APCC_DBOX_1	0.2222
p.S568F	ACH-002222	Leukemia	CCLE	LRRSLEAIK	DEG_APCC_DBOX_1	0.2222
p.S568F	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LRRSLEAIK	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P3S6	F-box only protein 42	DEG_APCC_DBOX_1	556:564	LRRSLEAIK	APC,CDC20,FZR1	0.9251	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons