DegronMD

Uniprot ID: Q6P3S6

Source protein: F-box only protein 42

Source gene: FBXO42

Class: DEG_Kelch_Keap1_1

Location: 592:597

E3 ligase: KEAP1

DEGRON score: 0.9619

ASA_SCORE: 76.1167

COIL: 0.898

CONS_SCORE: 0.3484

DSS_SCORE: 0.7793

HELIX: 0.0525

FCONS_SCORE: 0.9441

RIG_SCORE: 0.5077

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P585T	TCGA-EE-A2MM	SKCM	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.1389
p.P585T	DO37770	SKCM	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.1389
p.R603C	TCGA-FR-A726	SKCM	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.1667
p.R603C	DO48665	SKCM	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.1667
p.R603C	SIDM01059	Melanoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1667
p.R603C	ACH-000915	Skin Cancer	CCLE	SLSSGE	DEG_Kelch_Keap1_1	0.1667
p.R603C	IPC-298	skin	COSMIC	SLSSGE	DEG_Kelch_Keap1_1	0.1667
p.G596E	TCGA-FS-A1ZK	SKCM	TCGA	SLSSGE	DEG_Kelch_Keap1_1	0.7199
p.G596E	DO37474	SKCM	ICGC	SLSSGE	DEG_Kelch_Keap1_1	0.7199
p.P604S	SIDM01175	Other Sarcomas	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.1389
p.P604S	ACH-002309	Sarcoma	CCLE	SLSSGE	DEG_Kelch_Keap1_1	0.1389
p.P604S	SW684	soft_tissue	COSMIC	SLSSGE	DEG_Kelch_Keap1_1	0.1389
p.G589V	SIDM00217	Colorectal Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	0.25
p.G589V	ACH-000999	Colon/Colorectal Cancer	CCLE	SLSSGE	DEG_Kelch_Keap1_1	0.25
p.G589V	SNU-1040	large_intestine	COSMIC	SLSSGE	DEG_Kelch_Keap1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15021	Microtubule-associated serine/threonine-protein kinase 4	DEG_Kelch_Keap1_1	1290:1295	SLSSGE	KEAP1	0.9965	More...
P04150	Glucocorticoid receptor	DEG_Kelch_Keap1_1	111:116	SLSSGE	KEAP1	0.6996	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_Kelch_Keap1_1	1254:1259	SLSSGE	KEAP1	0.9967	More...
Q8IY81	pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3	DEG_Kelch_Keap1_1	333:338	SLSSGE	KEAP1	0.9727	More...
Q8TDX9	Polycystic kidney disease protein 1-like 1	DEG_Kelch_Keap1_1	1160:1165	SLSSGE	KEAP1	0.6964	More...
Q6P3S6	F-box only protein 42	DEG_Kelch_Keap1_1	592:597	SLSSGE	KEAP1	0.9619	More...
Q96BV0	Zinc finger protein 775	DEG_Kelch_Keap1_1	99:104	SLSSGE	KEAP1	0.7671	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons