DegronMD - Q6P0Q8(MAST2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1646H	TCGA-06-5416	GBM	TCGA	PPSST	DEG_SPOP_SBC_1	1645:1649	Mutation altering degron motif	0.6583
p.L1098F	TCGA-18-3409	LUSC	TCGA	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation altering degron motif	0.6981
p.L1098F	DO26444	LUSC	ICGC	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation altering degron motif	0.6981
p.L1098F	ACH-001610	Brain Cancer	CCLE	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation altering degron motif	0.6981
p.E1192D	TCGA-29-A5NZ	OV	TCGA	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation rewiring degron network	0.25
p.E475G	TCGA-43-3920	LUSC	TCGA	TRDPLEEMA	DEG_APCC_DBOX_1	469:477	Mutation altering degron motif	0.6087
p.S1644C	TCGA-58-A46J	LUSC	TCGA	LTPTSS	DEG_SCF_FBW7_1	1637:1642	Mutation rewiring degron network	0.2778
p.S1644C	TCGA-58-A46J	LUSC	TCGA	PPSST	DEG_SPOP_SBC_1	1645:1649	Mutation rewiring degron network	0.3056
p.S1633I	TCGA-78-8640	LUAD	TCGA	LTPTSS	DEG_SCF_FBW7_1	1637:1642	Mutation rewiring degron network	0.2222
p.R222C	TCGA-90-A4ED	LUSC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.1944
p.R222C	DO230312	COCA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.1944
p.R222C	DO45482	LUSC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.1944
p.S1635L	TCGA-A5-A2K5	UCEC	TCGA	LTPTSS	DEG_SCF_FBW7_1	1637:1642	Mutation rewiring degron network	0.2778
p.S1635L	TCGA-A5-A2K5	UCEC	TCGA	PPSST	DEG_SPOP_SBC_1	1645:1649	Mutation rewiring degron network	0.0556
p.R460C	TCGA-AJ-A3BG	UCEC	TCGA	TRDPLEEMA	DEG_APCC_DBOX_1	469:477	Mutation rewiring degron network	0.0833
p.R169Q	TCGA-B5-A11E	UCEC	TCGA	VTSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.0833
p.R169Q	TCGA-EY-A1GL	UCEC	TCGA	VTSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.0833
p.R169Q	DO41644	UCEC	ICGC	VTSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.0833
p.R169Q	DO41181	UCEC	ICGC	VTSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.0833
p.R169Q	SIDM01686	Chronic Myelogenous Leukemia	GDSC	VTSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.0833
p.R169Q	ACH-000462	Leukemia	CCLE	VTSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.0833
p.P235L	TCGA-B5-A1MX	UCEC	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	227:235	Mutation altering degron motif	0.6471
p.P235L	DO41999	UCEC	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	227:235	Mutation altering degron motif	0.6471
p.P485A	TCGA-C8-A12T	BRCA	TCGA	TRDPLEEMA	DEG_APCC_DBOX_1	469:477	Mutation rewiring degron network	0.1111
p.R1246C	TCGA-CD-8536	STAD	TCGA	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.1111
p.R1246C	TCGA-F4-6856	COAD	TCGA	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.1111
p.P114S	TCGA-DA-A3F8	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	114:118	Mutation altering degron motif	0.6752
p.P114S	DO37418	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	114:118	Mutation altering degron motif	0.6752
p.M476V	TCGA-DD-A1EE	LIHC	TCGA	TRDPLEEMA	DEG_APCC_DBOX_1	469:477	Mutation altering degron motif	0.6097
p.P114T	TCGA-EE-A2GR	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	114:118	Mutation altering degron motif	0.7031
p.P114T	DO37996	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	114:118	Mutation altering degron motif	0.7031
p.Q125H	TCGA-EO-A22T	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	114:118	Mutation rewiring degron network	0.1389
p.Q125H	DO42320	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	114:118	Mutation rewiring degron network	0.1389
p.P1104L	TCGA-EO-A22U	UCEC	TCGA	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation rewiring degron network	0.1944
p.P1104L	DO43755	UCEC	ICGC	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation rewiring degron network	0.1944
p.P1262A	TCGA-F4-6570	COAD	TCGA	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.25
p.W1658C	TCGA-FD-A3N5	BLCA	TCGA	PPSST	DEG_SPOP_SBC_1	1645:1649	Mutation rewiring degron network	0.0833
p.T1638N	TCGA-FD-A5BU	BLCA	TCGA	LTPTSS	DEG_SCF_FBW7_1	1637:1642	Mutation altering degron motif	0.7055
p.H1108Y	TCGA-FS-A1ZW	SKCM	TCGA	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation rewiring degron network	0.0833
p.H1108Y	DO37519	SKCM	ICGC	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation rewiring degron network	0.0833
p.P485S	TCGA-GN-A26C	SKCM	TCGA	TRDPLEEMA	DEG_APCC_DBOX_1	469:477	Mutation rewiring degron network	0.1111
p.L1630I	TCGA-L5-A43J	ESCA	TCGA	LTPTSS	DEG_SCF_FBW7_1	1637:1642	Mutation rewiring degron network	0.1389
p.R1086W	TCGA-LN-A49V	ESCA	TCGA	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation rewiring degron network	0.1944
p.S230A	TCGA-NJ-A4YI	LUAD	TCGA	RRWSLASLP	DEG_APCC_DBOX_1	227:235	Mutation altering degron motif	0.7588
p.S230A	DO218942	LUAD	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	227:235	Mutation altering degron motif	0.7588
p.L112M	TCGA-NJ-A4YP	LUAD	TCGA	PLSSS	DEG_SPOP_SBC_1	114:118	Mutation rewiring degron network	0.2778
p.L112M	DO218943	LUAD	ICGC	PLSSS	DEG_SPOP_SBC_1	114:118	Mutation rewiring degron network	0.2778
p.S183L	TCGA-Q1-A73O	CESC	TCGA	VTSST	DEG_SPOP_SBC_1	178:182	Mutation blocking phosphorylation signal	0.75
p.S183L	DO51612	CESC	ICGC	VTSST	DEG_SPOP_SBC_1	178:182	Mutation blocking phosphorylation signal	0.75
p.E1175Q	TCGA-XF-A9SM	BLCA	TCGA	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation rewiring degron network	0.0556
p.E1082K	DO48459	BLCA	ICGC	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation rewiring degron network	0.0833
p.E1082Q	DO223597	BLCA	ICGC	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation rewiring degron network	0.0833
p.E1250K	DO4012	BRCA	ICGC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation blocking phosphorylation signal	0.6667
p.M470I	DO6088	BRCA	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	469:477	Mutation altering degron motif	0.7618
p.M470I	DO228974	LICA	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	469:477	Mutation altering degron motif	0.7618
p.A1193V	DO8119	COAD	ICGC	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation rewiring degron network	0.2222
p.P1252L	DO8119	COAD	ICGC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.2778
p.P187Q	DO230323	COCA	ICGC	VTSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1944
p.R1188W	DO227549	COCA	ICGC	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation altering degron motif	0.8634
p.R227W	DO234315	ESAD	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	227:235	Mutation altering degron motif	0.7523
p.K1104R	DO234285	ESAD	ICGC	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation rewiring degron network	0.1944
p.I473V	DO223144	ESCA	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	469:477	Mutation altering degron motif	0.7076
p.R228C	DO225448	GACA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	227:235	Mutation altering degron motif	0.8301
p.R467H	DO233203	GACA	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	469:477	Mutation rewiring degron network	0.2778
p.R467H	DO27985	OV	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	469:477	Mutation rewiring degron network	0.2778
p.R1254M	DO18938	KIRC	ICGC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation altering degron motif	0.8632
p.R1254M	DO37631	SKCM	ICGC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation altering degron motif	0.8632
p.V1105L	DO228937	LICA	ICGC	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation rewiring degron network	0.1667
p.K472N	DO228948	LICA	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	469:477	Mutation altering degron motif	0.6918
p.S118I	DO228976	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	114:118	Mutation altering degron motif	0.8453
p.R460L	DO229028	LICA	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	469:477	Mutation rewiring degron network	0.0833
p.R460L	DO26502	LUSC	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	469:477	Mutation rewiring degron network	0.0833
p.E1603D	DO229022	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	1592:1596	Mutation rewiring degron network	0.1389
p.R222H	DO229056	LICA	ICGC	RRWSLASLP	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.1944
p.R1188Q	DO219533	LIHC	ICGC	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation altering degron motif	0.7329
p.Q125E	DO23498	LINC	ICGC	PLSSS	DEG_SPOP_SBC_1	114:118	Mutation rewiring degron network	0.1389
p.S1182Y	DO229177	LMS	ICGC	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation rewiring degron network	0.25
p.S1269F	DO45318	LUAD	ICGC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.0556
p.R460W	DO26250	LUAD	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	469:477	Mutation rewiring degron network	0.0833
p.R460W	DO42673	UCEC	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	469:477	Mutation rewiring degron network	0.0833
p.R1109W	DO27532	LUSC	ICGC	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation rewiring degron network	0.0556
p.P1258F	DO222504	MELA	ICGC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation altering degron motif	0.7897
p.E1099D	DO50084	OV	ICGC	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation altering degron motif	0.6758
p.R1583K	DO28491	OV	ICGC	AASSS	DEG_SPOP_SBC_1	1592:1596	Mutation rewiring degron network	0.0833
p.P1097A	DO47088	RECA	ICGC	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation altering degron motif	0.7503
p.R1188L	DO37715	SKCM	ICGC	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation altering degron motif	0.8428
p.R481L	DO37491	SKCM	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	469:477	Mutation rewiring degron network	0.2222
p.R481L	DO37916	SKCM	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	469:477	Mutation rewiring degron network	0.2222
p.R467C	DO38887	STAD	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	469:477	Mutation rewiring degron network	0.2778
p.P1180L	DO42023	UCEC	ICGC	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation blocking phosphorylation signal	0.6389
p.R465W	DO52399	UCEC	ICGC	TRDPLEEMA	DEG_APCC_DBOX_1	469:477	Mutation rewiring degron network	0.2222
p.P1180S	DO41235	UCEC	ICGC	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation blocking phosphorylation signal	0.6389
p.V1194A	DO41331	UCEC	ICGC	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation rewiring degron network	0.1944
p.P1190S	SIDM00608	Plasma Cell Myeloma	GDSC	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation rewiring degron network	0.3056
p.P1190S	SIDM00527	Colorectal Carcinoma	GDSC	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation rewiring degron network	0.3056
p.P1190S	ACH-000714	Myeloma	CCLE	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation rewiring degron network	0.3056
p.P1190S	ACH-000935	Colon/Colorectal Cancer	CCLE	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation rewiring degron network	0.3056
p.P1190S	KMS-11	haematopoietic and lymphoid tissue	COSMIC	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation rewiring degron network	0.3056
p.P1190S	MDST8	large intestine	COSMIC	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation rewiring degron network	0.3056
p.D1093H	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation altering degron motif	0.6577
p.D1093H	ACH-000365	Lymphoma	CCLE	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation altering degron motif	0.6577
p.D1093H	SU-DHL-4	haematopoietic and lymphoid tissue	COSMIC	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation altering degron motif	0.6577
p.L1637F	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPTSS	DEG_SCF_FBW7_1	1637:1642	Mutation altering degron motif	0.6981
p.L1637F	SIDM00722	Mesothelioma	GDSC	LTPTSS	DEG_SCF_FBW7_1	1637:1642	Mutation altering degron motif	0.6981
p.L1637F	SIDM00923	Cervical Carcinoma	GDSC	LTPTSS	DEG_SCF_FBW7_1	1637:1642	Mutation altering degron motif	0.6981
p.L1637F	SIDM00057	Neuroblastoma	GDSC	LTPTSS	DEG_SCF_FBW7_1	1637:1642	Mutation altering degron motif	0.6981
p.L1637F	SIDM01503	Small Cell Lung Carcinoma	GDSC	LTPTSS	DEG_SCF_FBW7_1	1637:1642	Mutation altering degron motif	0.6981
p.L1637F	SIDM01665	Colorectal Carcinoma	GDSC	LTPTSS	DEG_SCF_FBW7_1	1637:1642	Mutation altering degron motif	0.6981
p.R1246L	SIDM00608	Plasma Cell Myeloma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.1111
p.R1246L	SIDM01040	Ovarian Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.1111
p.R1246L	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.1111
p.R1246L	SIDM00491	Thyroid Gland Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.1111
p.R1246L	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.1111
p.R1246L	SIDM00362	Burkitt's Lymphoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.1111
p.R1246L	SIDM00296	Small Cell Lung Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.1111
p.R1246L	SIDM00592	Oral Cavity Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.1111
p.R1246L	SIDM00351	Oral Cavity Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.1111
p.R1246L	SIDM00687	Gastric Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.1111
p.R1246L	SIDM00287	B-Lymphoblastic Leukemia	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.1111
p.R1246L	SIDM00292	Small Cell Lung Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.1111
p.R1246L	SIDM00294	Small Cell Lung Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.1111
p.R1246L	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.1111
p.R1246L	SIDM00240	Cervical Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.1111
p.R1246L	SIDM00239	Kidney Carcinoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.1111
p.R1246L	SIDM01447	Glioblastoma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.1111
p.R1246L	SIDM01473	Plasma Cell Myeloma	GDSC	SLSSGE	DEG_Kelch_Keap1_1	1254:1259	Mutation rewiring degron network	0.1111
p.R173C	SIDM00216	Colorectal Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1944
p.R173C	ACH-000989	Colon/Colorectal Cancer	CCLE	VTSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1944
p.R173C	SNU-175	large intestine	COSMIC	VTSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1944
p.M1101L	SIDM00845	Burkitt's Lymphoma	GDSC	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation rewiring degron network	0.2778
p.M1101L	SIDM00461	Acute Myeloid Leukemia	GDSC	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation rewiring degron network	0.2778
p.M1101L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation rewiring degron network	0.2778
p.M1101L	ACH-000786	Lymphoma	CCLE	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation rewiring degron network	0.2778
p.M1101L	ACH-000992	Head and Neck Cancer	CCLE	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation rewiring degron network	0.2778
p.M1101L	ACH-001067	Brain Cancer	CCLE	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation rewiring degron network	0.2778
p.S121T	SIDM00525	Osteosarcoma	GDSC	PLSSS	DEG_SPOP_SBC_1	114:118	Mutation rewiring degron network	0.25
p.S121T	SIDM00865	Small Cell Lung Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	114:118	Mutation rewiring degron network	0.25
p.S1596C	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	1592:1596	Mutation altering degron motif	0.7541
p.S1596C	ACH-002313	Lymphoma	CCLE	AASSS	DEG_SPOP_SBC_1	1592:1596	Mutation altering degron motif	0.7541
p.S1596C	TK	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	1592:1596	Mutation altering degron motif	0.7541
p.K174N	SIDM00272	Breast Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	178:182	Mutation substituting flanking lysine	0.3333
p.K174N	ACH-000910	Breast Cancer	CCLE	VTSST	DEG_SPOP_SBC_1	178:182	Mutation substituting flanking lysine	0.3333
p.K174N	MDA-MB-453	breast	COSMIC	VTSST	DEG_SPOP_SBC_1	178:182	Mutation substituting flanking lysine	0.3333
p.P1090S	SIDM00414	Bladder Carcinoma	GDSC	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation rewiring degron network	0.3056
p.P1090S	ACH-000545	Bladder Cancer	CCLE	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation rewiring degron network	0.3056
p.P1090S	VM-CUB-1	urinary tract	COSMIC	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation rewiring degron network	0.3056
p.S1091R	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation altering degron motif	0.6316
p.S1091R	NCI-H1993	lung	COSMIC	SRDFLPALG	DEG_APCC_DBOX_1	1091:1099	Mutation altering degron motif	0.6316
p.A1588T	SIDM00121	T-Lymphoblastic Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	1592:1596	Mutation rewiring degron network	0.2222
p.A1588T	ACH-001738	Leukemia	CCLE	AASSS	DEG_SPOP_SBC_1	1592:1596	Mutation rewiring degron network	0.2222
p.A1588T	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	1592:1596	Mutation rewiring degron network	0.2222
p.R188Q	SIDM00612	Glioma	GDSC	VTSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1667
p.R188Q	ACH-002257	Brain Cancer	CCLE	VTSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1667
p.R188Q	KINGS-1	central nervous system	COSMIC	VTSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1667
p.K1197E	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation blocking ubiquitination signal	0.5556
p.K1197E	ACH-000855	Esophageal Cancer	CCLE	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation blocking ubiquitination signal	0.5556
p.K1197E	KYSE-150	oesophagus	COSMIC	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation blocking ubiquitination signal	0.5556
p.N1193S	SIDM00980	Gastric Carcinoma	GDSC	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation rewiring degron network	0.2222
p.N1193S	ACH-000948	Gastric Cancer	CCLE	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation rewiring degron network	0.2222
p.N1193S	23132-87	stomach	COSMIC	AISTT	DEG_SPOP_SBC_1	1185:1189	Mutation rewiring degron network	0.2222
p.P189S	SIDM01608	Endometrial Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1389
p.P189S	ACH-000990	Endometrial/Uterine Cancer	CCLE	VTSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1389
p.G1599D	SIDM01564	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	1592:1596	Mutation rewiring degron network	0.25
p.G1599D	ACH-000214	Non-Cancerous	CCLE	AASSS	DEG_SPOP_SBC_1	1592:1596	Mutation rewiring degron network	0.25
p.R175H	PA-1	ovary	COSMIC	VTSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.25
p.R173Q	CAL-85-1	breast	COSMIC	VTSST	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAST2

UniProt ID: Q6P0Q8

Entrez ID: 23139

Protein name: Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAST2 in