DegronMD

Uniprot ID: Q6P0Q8

Source protein: Microtubule-associated serine/threonine-protein kinase 2

Source gene: MAST2

Class: DEG_SPOP_SBC_1

Location: 178:182

E3 ligase: SPOP

DEGRON score: 0.8042

ASA_SCORE: 92.6

COIL: 0.9086

CONS_SCORE: 0.334

DSS_SCORE: 0.6446

HELIX: 0.0234

FCONS_SCORE: 0.8914

RIG_SCORE: 0.6529

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R169Q	TCGA-B5-A11E	UCEC	TCGA	VTSST	DEG_SPOP_SBC_1	0.0833
p.R169Q	TCGA-EY-A1GL	UCEC	TCGA	VTSST	DEG_SPOP_SBC_1	0.0833
p.R169Q	DO41644	UCEC	ICGC	VTSST	DEG_SPOP_SBC_1	0.0833
p.R169Q	DO41181	UCEC	ICGC	VTSST	DEG_SPOP_SBC_1	0.0833
p.R169Q	SIDM01686	Chronic Myelogenous Leukemia	GDSC	VTSST	DEG_SPOP_SBC_1	0.0833
p.R169Q	ACH-000462	Leukemia	CCLE	VTSST	DEG_SPOP_SBC_1	0.0833
p.S183L	TCGA-Q1-A73O	CESC	TCGA	VTSST	DEG_SPOP_SBC_1	0.75
p.S183L	DO51612	CESC	ICGC	VTSST	DEG_SPOP_SBC_1	0.75
p.P187Q	DO230323	COCA	ICGC	VTSST	DEG_SPOP_SBC_1	0.1944
p.R173C	SIDM00216	Colorectal Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	0.1944
p.R173C	ACH-000989	Colon/Colorectal Cancer	CCLE	VTSST	DEG_SPOP_SBC_1	0.1944
p.R173C	SNU-175	large_intestine	COSMIC	VTSST	DEG_SPOP_SBC_1	0.1944
p.K174N	SIDM00272	Breast Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	0.3333
p.K174N	ACH-000910	Breast Cancer	CCLE	VTSST	DEG_SPOP_SBC_1	0.3333
p.K174N	MDA-MB-453	breast	COSMIC	VTSST	DEG_SPOP_SBC_1	0.3333
p.R188Q	SIDM00612	Glioma	GDSC	VTSST	DEG_SPOP_SBC_1	0.1667
p.R188Q	ACH-002257	Brain Cancer	CCLE	VTSST	DEG_SPOP_SBC_1	0.1667
p.R188Q	KINGS-1	central_nervous_system	COSMIC	VTSST	DEG_SPOP_SBC_1	0.1667
p.P189S	SIDM01608	Endometrial Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	0.1389
p.P189S	ACH-000990	Endometrial/Uterine Cancer	CCLE	VTSST	DEG_SPOP_SBC_1	0.1389
p.R175H	PA-1	ovary	COSMIC	VTSST	DEG_SPOP_SBC_1	0.25
p.R173Q	CAL-85-1	breast	COSMIC	VTSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	258:262	VTSST	SPOP	0.8479	More...
P35908	Keratin, type II cytoskeletal 2 epidermal	DEG_SPOP_SBC_1	503:507	VTSST	SPOP	0.842	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	303:307	VTSST	SPOP	0.9985	More...
Q06330	Recombining binding protein suppressor of hairless	DEG_SPOP_SBC_1	491:495	VTSST	SPOP	0.9106	More...
Q5T1M5	FK506-binding protein 15	DEG_SPOP_SBC_1	1128:1132	VTSST	SPOP	0.8902	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	178:182	VTSST	SPOP	0.8042	More...
Q8TEU7	Rap guanine nucleotide exchange factor 6	DEG_SPOP_SBC_1	1479:1483	VTSST	SPOP	0.8438	More...
Q9NPG3	Ubinuclein-1	DEG_SPOP_SBC_1	1001:1005	VTSST	SPOP	0.9937	More...
Q9UJM3	ERBB receptor feedback inhibitor 1	DEG_SPOP_SBC_1	305:309	VTSST	SPOP	0.9829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons