DegronMD - Q9NPG3(UBN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K874N	TCGA-A5-A0G2	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	867:871	Mutation substituting flanking lysine	0.3611
p.K874N	DO228976	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	867:871	Mutation substituting flanking lysine	0.3611
p.K874N	DO41235	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	867:871	Mutation substituting flanking lysine	0.3611
p.S878L	TCGA-AP-A1DV	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	876:880	Mutation altering degron motif	0.7667
p.S878L	DO43186	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	876:880	Mutation altering degron motif	0.7667
p.S878L	SIDM00210	Ovarian Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	876:880	Mutation altering degron motif	0.7667
p.S878L	SIDM00875	Breast Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	876:880	Mutation altering degron motif	0.7667
p.A848S	TCGA-CK-6746	COAD	TCGA	HRSLLQLVK	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.2778
p.A848S	DO7938	COAD	ICGC	HRSLLQLVK	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.2778
p.T875A	TCGA-CZ-5468	KIRC	TCGA	ASSSS	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.2222
p.T875A	TCGA-CZ-5468	KIRC	TCGA	PASSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.3056
p.T875A	DO18332	KIRC	ICGC	ASSSS	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.2222
p.T875A	DO18332	KIRC	ICGC	PASSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.3056
p.P856S	TCGA-DA-A1HY	SKCM	TCGA	HRSLLQLVK	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.0556
p.P856S	DO37409	SKCM	ICGC	HRSLLQLVK	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.0556
p.S1003L	TCGA-DU-6392	LGG	TCGA	VTSST	DEG_SPOP_SBC_1	1001:1005	Mutation altering degron motif	0.7667
p.S1003L	DO22237	LGG	ICGC	VTSST	DEG_SPOP_SBC_1	1001:1005	Mutation altering degron motif	0.7667
p.S879F	TCGA-EE-A2MR	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	876:880	Mutation altering degron motif	0.7982
p.S879F	DO37819	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	876:880	Mutation altering degron motif	0.7982
p.S881F	TCGA-EK-A3GJ	CESC	TCGA	ASSSS	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.0556
p.S881F	TCGA-EK-A3GJ	CESC	TCGA	PASSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.3056
p.S881F	DO49962	CESC	ICGC	ASSSS	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.0556
p.S881F	DO49962	CESC	ICGC	PASSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.3056
p.P991S	TCGA-GN-A4U4	SKCM	TCGA	VTSST	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.0556
p.P991S	DO51256	SKCM	ICGC	VTSST	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.0556
p.H838D	DO48413	BLCA	ICGC	HRSLLQLVK	DEG_APCC_DBOX_1	838:846	Mutation altering degron motif	0.6577
p.A882V	DO48413	BLCA	ICGC	PASSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.2778
p.A849V	DO230346	COCA	ICGC	HRSLLQLVK	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.25
p.V998F	DO228952	LICA	ICGC	VTSST	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.25
p.L1007F	DO228971	LICA	ICGC	VTSST	DEG_SPOP_SBC_1	1001:1005	Mutation rewiring degron network	0.2778
p.A887S	DO228985	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.1389
p.L841F	SIDM00454	Rhabdomyosarcoma	GDSC	HRSLLQLVK	DEG_APCC_DBOX_1	838:846	Mutation altering degron motif	0.587
p.L841F	SIDM00210	Ovarian Carcinoma	GDSC	HRSLLQLVK	DEG_APCC_DBOX_1	838:846	Mutation altering degron motif	0.587
p.L841F	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	HRSLLQLVK	DEG_APCC_DBOX_1	838:846	Mutation altering degron motif	0.587
p.L841F	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	HRSLLQLVK	DEG_APCC_DBOX_1	838:846	Mutation altering degron motif	0.587
p.L841F	SIDM00254	Neuroblastoma	GDSC	HRSLLQLVK	DEG_APCC_DBOX_1	838:846	Mutation altering degron motif	0.587
p.L841F	SIDM00760	Small Cell Lung Carcinoma	GDSC	HRSLLQLVK	DEG_APCC_DBOX_1	838:846	Mutation altering degron motif	0.587
p.A832T	SIDM01387	Small Cell Lung Carcinoma	GDSC	HRSLLQLVK	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.1667
p.A832T	ACH-000921	Lung Cancer	CCLE	HRSLLQLVK	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.1667

Kaplan plot for UBN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBN1

UniProt ID: Q9NPG3

Entrez ID: 29855

Protein name: Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UBN1 in