DegronMD

Uniprot ID: Q9NPG3

Source protein: Ubinuclein-1

Source gene: UBN1

Class: DEG_APCC_DBOX_1

Location: 838:846

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9768

ASA_SCORE: 112.0556

COIL: 0.5568

CONS_SCORE: 0.3556

DSS_SCORE: 0.5264

HELIX: 0.4207

FCONS_SCORE: 1.0757

RIG_SCORE: 0.8075

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A848S	TCGA-CK-6746	COAD	TCGA	HRSLLQLVK	DEG_APCC_DBOX_1	0.2778
p.A848S	DO7938	COAD	ICGC	HRSLLQLVK	DEG_APCC_DBOX_1	0.2778
p.P856S	TCGA-DA-A1HY	SKCM	TCGA	HRSLLQLVK	DEG_APCC_DBOX_1	0.0556
p.P856S	DO37409	SKCM	ICGC	HRSLLQLVK	DEG_APCC_DBOX_1	0.0556
p.H838D	DO48413	BLCA	ICGC	HRSLLQLVK	DEG_APCC_DBOX_1	0.6577
p.A849V	DO230346	COCA	ICGC	HRSLLQLVK	DEG_APCC_DBOX_1	0.25
p.L841F	SIDM00454	Rhabdomyosarcoma	GDSC	HRSLLQLVK	DEG_APCC_DBOX_1	0.587
p.L841F	SIDM00210	Ovarian Carcinoma	GDSC	HRSLLQLVK	DEG_APCC_DBOX_1	0.587
p.L841F	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	HRSLLQLVK	DEG_APCC_DBOX_1	0.587
p.L841F	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	HRSLLQLVK	DEG_APCC_DBOX_1	0.587
p.L841F	SIDM00254	Neuroblastoma	GDSC	HRSLLQLVK	DEG_APCC_DBOX_1	0.587
p.L841F	SIDM00760	Small Cell Lung Carcinoma	GDSC	HRSLLQLVK	DEG_APCC_DBOX_1	0.587
p.A832T	SIDM01387	Small Cell Lung Carcinoma	GDSC	HRSLLQLVK	DEG_APCC_DBOX_1	0.1667
p.A832T	ACH-000921	Lung Cancer	CCLE	HRSLLQLVK	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NPG3	Ubinuclein-1	DEG_APCC_DBOX_1	838:846	HRSLLQLVK	APC,CDC20,FZR1	0.9768	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons