DegronMD

Uniprot ID: Q5T1M5

Source protein: FK506-binding protein 15

Source gene: FKBP15

Class: DEG_SPOP_SBC_1

Location: 1128:1132

E3 ligase: SPOP

DEGRON score: 0.8902

ASA_SCORE: 90.52

COIL: 0.9638

CONS_SCORE: 0.3994

DSS_SCORE: 0.7913

HELIX: 0.0168

FCONS_SCORE: 1.0599

RIG_SCORE: 0.575

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1131T	TCGA-13-0903	OV	TCGA	VTSST	DEG_SPOP_SBC_1	0.6005
p.S1131T	DO32616	OV	ICGC	VTSST	DEG_SPOP_SBC_1	0.6005
p.Q1119E	TCGA-4Z-AA7R	BLCA	TCGA	VTSST	DEG_SPOP_SBC_1	0.0833
p.Q1119E	DO51866	BLCA	ICGC	VTSST	DEG_SPOP_SBC_1	0.0833
p.T1132I	TCGA-AP-A059	UCEC	TCGA	VTSST	DEG_SPOP_SBC_1	0.7078
p.T1132I	DO41361	UCEC	ICGC	VTSST	DEG_SPOP_SBC_1	0.7078
p.P1118R	TCGA-AP-A1DV	UCEC	TCGA	VTSST	DEG_SPOP_SBC_1	0.0556
p.P1118R	DO43186	UCEC	ICGC	VTSST	DEG_SPOP_SBC_1	0.0556
p.S1131P	DO228542	GACA	ICGC	VTSST	DEG_SPOP_SBC_1	0.6752
p.S1130R	DO229038	LICA	ICGC	VTSST	DEG_SPOP_SBC_1	0.7427
p.P1118S	SIDM02015	Colorectal Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	258:262	VTSST	SPOP	0.8479	More...
P35908	Keratin, type II cytoskeletal 2 epidermal	DEG_SPOP_SBC_1	503:507	VTSST	SPOP	0.842	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	303:307	VTSST	SPOP	0.9985	More...
Q06330	Recombining binding protein suppressor of hairless	DEG_SPOP_SBC_1	491:495	VTSST	SPOP	0.9106	More...
Q5T1M5	FK506-binding protein 15	DEG_SPOP_SBC_1	1128:1132	VTSST	SPOP	0.8902	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	178:182	VTSST	SPOP	0.8042	More...
Q8TEU7	Rap guanine nucleotide exchange factor 6	DEG_SPOP_SBC_1	1479:1483	VTSST	SPOP	0.8438	More...
Q9NPG3	Ubinuclein-1	DEG_SPOP_SBC_1	1001:1005	VTSST	SPOP	0.9937	More...
Q9UJM3	ERBB receptor feedback inhibitor 1	DEG_SPOP_SBC_1	305:309	VTSST	SPOP	0.9829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons