DegronMD

Uniprot ID: P35908

Source protein: Keratin, type II cytoskeletal 2 epidermal

Source gene: KRT2

Class: DEG_SPOP_SBC_1

Location: 503:507

E3 ligase: SPOP

DEGRON score: 0.842

ASA_SCORE: 69.08

COIL: 0.59

CONS_SCORE: 0.266

DSS_SCORE: 0.3311

HELIX: 0.0128

FCONS_SCORE: 0.8165

RIG_SCORE: 0.7589

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T504K	TCGA-24-1847	OV	TCGA	VTSST	DEG_SPOP_SBC_1	0.6195
p.T504K	DO31080	OV	ICGC	VTSST	DEG_SPOP_SBC_1	0.6195
p.S509L	TCGA-3N-A9WD	SKCM	TCGA	VTSST	DEG_SPOP_SBC_1	0.2778
p.S509L	TCGA-FJ-A3ZE	BLCA	TCGA	VTSST	DEG_SPOP_SBC_1	0.2778
p.S509L	DO484	BLCA	ICGC	VTSST	DEG_SPOP_SBC_1	0.2778
p.S509L	DO51235	SKCM	ICGC	VTSST	DEG_SPOP_SBC_1	0.2778
p.S496R	DO229038	LICA	ICGC	VTSST	DEG_SPOP_SBC_1	0.1389
p.A517G	SIDM00672	Hepatocellular Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	0.0556
p.A517G	SIDM00882	Breast Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	0.0556
p.A517G	SIDM00793	Burkitt's Lymphoma	GDSC	VTSST	DEG_SPOP_SBC_1	0.0556
p.A517G	SIDM00808	Burkitt's Lymphoma	GDSC	VTSST	DEG_SPOP_SBC_1	0.0556
p.A517G	SIDM01409	Bladder Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	0.0556
p.A517G	SIDM01254	Burkitt's Lymphoma	GDSC	VTSST	DEG_SPOP_SBC_1	0.0556
p.T500I	SIDM00719	Small Cell Lung Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	0.25
p.T500I	ACH-001364	Lung Cancer	CCLE	VTSST	DEG_SPOP_SBC_1	0.25
p.T500I	NCI-H345	lung	COSMIC	VTSST	DEG_SPOP_SBC_1	0.25
p.D494H	SIDM00888	Other Solid Cancers	GDSC	VTSST	DEG_SPOP_SBC_1	0.0833
p.D494H	ACH-000055	Brain Cancer	CCLE	VTSST	DEG_SPOP_SBC_1	0.0833
p.D494H	D-283MED	central_nervous_system	COSMIC	VTSST	DEG_SPOP_SBC_1	0.0833
p.G493E	SIDM00140	Melanoma	GDSC	VTSST	DEG_SPOP_SBC_1	0.0556
p.G493E	ACH-000968	Skin Cancer	CCLE	VTSST	DEG_SPOP_SBC_1	0.0556
p.G493E	COLO-792	skin	COSMIC	VTSST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	258:262	VTSST	SPOP	0.8479	More...
P35908	Keratin, type II cytoskeletal 2 epidermal	DEG_SPOP_SBC_1	503:507	VTSST	SPOP	0.842	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	303:307	VTSST	SPOP	0.9985	More...
Q06330	Recombining binding protein suppressor of hairless	DEG_SPOP_SBC_1	491:495	VTSST	SPOP	0.9106	More...
Q5T1M5	FK506-binding protein 15	DEG_SPOP_SBC_1	1128:1132	VTSST	SPOP	0.8902	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	178:182	VTSST	SPOP	0.8042	More...
Q8TEU7	Rap guanine nucleotide exchange factor 6	DEG_SPOP_SBC_1	1479:1483	VTSST	SPOP	0.8438	More...
Q9NPG3	Ubinuclein-1	DEG_SPOP_SBC_1	1001:1005	VTSST	SPOP	0.9937	More...
Q9UJM3	ERBB receptor feedback inhibitor 1	DEG_SPOP_SBC_1	305:309	VTSST	SPOP	0.9829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons