DegronMD

Uniprot ID: Q8TEU7

Source protein: Rap guanine nucleotide exchange factor 6

Source gene: RAPGEF6

Class: DEG_SPOP_SBC_1

Location: 1479:1483

E3 ligase: SPOP

DEGRON score: 0.8438

ASA_SCORE: 66.42

COIL: 0.537

CONS_SCORE: 0.3079

DSS_SCORE: 0.3737

HELIX: 0.048

FCONS_SCORE: 0.98

RIG_SCORE: 0.748

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1473S	DO10880	GBM	ICGC	VTSST	DEG_SPOP_SBC_1	0.1667
p.S1490R	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VTSST	DEG_SPOP_SBC_1	0.5833
p.S1490R	ACH-002256	Leukemia	CCLE	VTSST	DEG_SPOP_SBC_1	0.5833
p.S1490R	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VTSST	DEG_SPOP_SBC_1	0.5833
p.A1473P	CAL-29	urinary_tract	COSMIC	VTSST	DEG_SPOP_SBC_1	0.1667
p.G1486C	NCI-H1993	lung	COSMIC	VTSST	DEG_SPOP_SBC_1	0.25
p.S1482R	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VTSST	DEG_SPOP_SBC_1	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	258:262	VTSST	SPOP	0.8479	More...
P35908	Keratin, type II cytoskeletal 2 epidermal	DEG_SPOP_SBC_1	503:507	VTSST	SPOP	0.842	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	303:307	VTSST	SPOP	0.9985	More...
Q06330	Recombining binding protein suppressor of hairless	DEG_SPOP_SBC_1	491:495	VTSST	SPOP	0.9106	More...
Q5T1M5	FK506-binding protein 15	DEG_SPOP_SBC_1	1128:1132	VTSST	SPOP	0.8902	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	178:182	VTSST	SPOP	0.8042	More...
Q8TEU7	Rap guanine nucleotide exchange factor 6	DEG_SPOP_SBC_1	1479:1483	VTSST	SPOP	0.8438	More...
Q9NPG3	Ubinuclein-1	DEG_SPOP_SBC_1	1001:1005	VTSST	SPOP	0.9937	More...
Q9UJM3	ERBB receptor feedback inhibitor 1	DEG_SPOP_SBC_1	305:309	VTSST	SPOP	0.9829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons