DegronMD - P35908(KRT2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T504K	TCGA-24-1847	OV	TCGA	VTSST	DEG_SPOP_SBC_1	503:507	Mutation altering degron motif	0.6195
p.T504K	DO31080	OV	ICGC	VTSST	DEG_SPOP_SBC_1	503:507	Mutation altering degron motif	0.6195
p.S509L	TCGA-3N-A9WD	SKCM	TCGA	VTSST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.2778
p.S509L	TCGA-FJ-A3ZE	BLCA	TCGA	VTSST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.2778
p.S509L	DO484	BLCA	ICGC	VTSST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.2778
p.S509L	DO51235	SKCM	ICGC	VTSST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.2778
p.S496R	DO229038	LICA	ICGC	VTSST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1389
p.A517G	SIDM00672	Hepatocellular Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0556
p.A517G	SIDM00882	Breast Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0556
p.A517G	SIDM00793	Burkitt's Lymphoma	GDSC	VTSST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0556
p.A517G	SIDM00808	Burkitt's Lymphoma	GDSC	VTSST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0556
p.A517G	SIDM01409	Bladder Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0556
p.A517G	SIDM01254	Burkitt's Lymphoma	GDSC	VTSST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0556
p.T500I	SIDM00719	Small Cell Lung Carcinoma	GDSC	VTSST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.T500I	ACH-001364	Lung Cancer	CCLE	VTSST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.T500I	NCI-H345	lung	COSMIC	VTSST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.D494H	SIDM00888	Other Solid Cancers	GDSC	VTSST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0833
p.D494H	ACH-000055	Brain Cancer	CCLE	VTSST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0833
p.D494H	D-283MED	central nervous system	COSMIC	VTSST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0833
p.G493E	SIDM00140	Melanoma	GDSC	VTSST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0556
p.G493E	ACH-000968	Skin Cancer	CCLE	VTSST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0556
p.G493E	COLO-792	skin	COSMIC	VTSST	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0556

Kaplan plot for KRT2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRT2

UniProt ID: P35908

Entrez ID: 3849

Protein name: Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KRT2 in