DegronMD - Q8TEU7(RAPGEF6)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1450A	TCGA-2W-A8YY	CESC	TCGA	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation rewiring degron network	0.1944
p.T1450A	DO223732	CESC	ICGC	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation rewiring degron network	0.1944
p.S705I	TCGA-78-7220	LUAD	TCGA	CRHSLAIMP	DEG_APCC_DBOX_1	712:720	Mutation blocking phosphorylation signal	0.5833
p.S705I	DO24409	LUAD	ICGC	CRHSLAIMP	DEG_APCC_DBOX_1	712:720	Mutation blocking phosphorylation signal	0.5833
p.R1400S	TCGA-94-A5I6	LUSC	TCGA	DPIAEVEPT	DEG_SIAH_1	1398:1406	Mutation altering degron motif	0.7427
p.R1400S	DO219176	LUSC	ICGC	DPIAEVEPT	DEG_SIAH_1	1398:1406	Mutation altering degron motif	0.7427
p.S1446Y	TCGA-B5-A0JY	UCEC	TCGA	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation rewiring degron network	0.0833
p.S1446Y	DO43041	UCEC	ICGC	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation rewiring degron network	0.0833
p.S1357Y	TCGA-BS-A0UF	UCEC	TCGA	DSGRGS	DEG_SCF_TRCP1_1	1359:1364	Mutation rewiring degron network	0.2778
p.S1357Y	DO41488	UCEC	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1359:1364	Mutation rewiring degron network	0.2778
p.I1362S	TCGA-EY-A215	UCEC	TCGA	DSGRGS	DEG_SCF_TRCP1_1	1359:1364	Mutation altering degron motif	0.7341
p.I1362S	DO42665	UCEC	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1359:1364	Mutation altering degron motif	0.7341
p.R1370C	TCGA-HC-7211	PRAD	TCGA	DSGRGS	DEG_SCF_TRCP1_1	1359:1364	Mutation rewiring degron network	0.1667
p.R1370C	DO36287	PRAD	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1359:1364	Mutation rewiring degron network	0.1667
p.H1360Q	TCGA-PK-A5HB	ACC	TCGA	DSGRGS	DEG_SCF_TRCP1_1	1359:1364	Mutation altering degron motif	0.7582
p.D1394V	TCGA-S9-A6WL	LGG	TCGA	DPIAEVEPT	DEG_SIAH_1	1398:1406	Mutation rewiring degron network	0.2222
p.D1394V	DO48616	LGG	ICGC	DPIAEVEPT	DEG_SIAH_1	1398:1406	Mutation rewiring degron network	0.2222
p.S1445R	TCGA-VQ-A8PO	STAD	TCGA	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation rewiring degron network	0.0556
p.S1445R	DO51773	STAD	ICGC	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation rewiring degron network	0.0556
p.T1450M	TCGA-VQ-A91E	STAD	TCGA	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation rewiring degron network	0.1944
p.T1450M	DO51784	STAD	ICGC	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation rewiring degron network	0.1944
p.T1450M	SIDM01112	Osteosarcoma	GDSC	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation rewiring degron network	0.1944
p.T1450M	SIDM01088	Endometrial Carcinoma	GDSC	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation rewiring degron network	0.1944
p.T1450M	SIDM01664	Prostate Carcinoma	GDSC	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation rewiring degron network	0.1944
p.T1457P	TCGA-WS-AB45	COAD	TCGA	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation altering degron motif	0.7031
p.T1457P	DO51734	COAD	ICGC	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation altering degron motif	0.7031
p.S1362N	DO222503	COCA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1359:1364	Mutation altering degron motif	0.7069
p.Q1460R	DO229010	COCA	ICGC	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation altering degron motif	0.7329
p.Q1460R	DO229013	COCA	ICGC	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation altering degron motif	0.7329
p.Q1460R	DO229016	COCA	ICGC	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation altering degron motif	0.7329
p.Q1460R	DO229003	COCA	ICGC	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation altering degron motif	0.7329
p.Q1460R	DO229005	COCA	ICGC	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation altering degron motif	0.7329
p.K1360T	DO222509	ESCA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1359:1364	Mutation altering degron motif	0.7306
p.E1464D	DO233900	GACA	ICGC	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation rewiring degron network	0.2778
p.G1473S	DO10880	GBM	ICGC	VTSST	DEG_SPOP_SBC_1	1479:1483	Mutation rewiring degron network	0.1667
p.D1526N	DO44454	HNSC	ICGC	PPDY	ITCH	1529:1532	Mutation rewiring degron network	0.25
p.T1501I	DO21487	LAML	ICGC	PPGY	ITCH	1508:1511	Mutation blocking phosphorylation signal	0.5833
p.S1369R	DO228944	LICA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1359:1364	Mutation rewiring degron network	0.1944
p.H1403N	DO228948	LICA	ICGC	DPIAEVEPT	DEG_SIAH_1	1398:1406	Mutation altering degron motif	0.7423
p.H711N	DO229031	LICA	ICGC	CRHSLAIMP	DEG_APCC_DBOX_1	712:720	Mutation rewiring degron network	0.3056
p.A1363D	DO229045	LICA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1359:1364	Mutation altering degron motif	0.7793
p.T709K	DO229008	LICA	ICGC	CRHSLAIMP	DEG_APCC_DBOX_1	712:720	Mutation rewiring degron network	0.25
p.P1503S	DO52169	LIHC	ICGC	PPGY	ITCH	1508:1511	Mutation rewiring degron network	0.1944
p.Y1509H	DO48733	LIRI	ICGC	PPGY	ITCH	1508:1511	Mutation altering degron motif	0.7229
p.Y1519F	DO223665	LUAD	ICGC	PPGY	ITCH	1508:1511	Mutation rewiring degron network	0.1111
p.Y1519F	DO223665	LUAD	ICGC	PPDY	ITCH	1529:1532	Mutation rewiring degron network	0.0556
p.Y1498C	DO231183	LUSC	ICGC	PPGY	ITCH	1508:1511	Mutation rewiring degron network	0.0556
p.Y1498C	SIDM00537	Colorectal Carcinoma	GDSC	PPGY	ITCH	1508:1511	Mutation rewiring degron network	0.0556
p.G1361E	DO222395	MELA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1359:1364	Mutation altering degron motif	0.7199
p.H1534Q	DO30620	OV	ICGC	PPDY	ITCH	1529:1532	Mutation rewiring degron network	0.2778
p.S1349L	DO35442	PACA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1359:1364	Mutation rewiring degron network	0.0556
p.D1526H	DO233550	PRAD	ICGC	PPDY	ITCH	1529:1532	Mutation rewiring degron network	0.25
p.P1514S	DO47652	SKCM	ICGC	PPGY	ITCH	1508:1511	Mutation rewiring degron network	0.25
p.P1538S	DO51276	SKCM	ICGC	PPDY	ITCH	1529:1532	Mutation rewiring degron network	0.1667
p.K1350N	DO219774	UCEC	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1359:1364	Mutation rewiring degron network	0.0833
p.S1523Y	DO41458	UCEC	ICGC	PPDY	ITCH	1529:1532	Mutation rewiring degron network	0.1667
p.K1360R	SIDM00845	Burkitt's Lymphoma	GDSC	DSGRGS	DEG_SCF_TRCP1_1	1359:1364	Mutation altering degron motif	0.7237
p.K1357T	SIDM00845	Burkitt's Lymphoma	GDSC	DSGRGS	DEG_SCF_TRCP1_1	1359:1364	Mutation rewiring degron network	0.2778
p.R713K	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	CRHSLAIMP	DEG_APCC_DBOX_1	712:720	Mutation altering degron motif	0.7237
p.R713K	NCI-H1299	lung	COSMIC	CRHSLAIMP	DEG_APCC_DBOX_1	712:720	Mutation altering degron motif	0.7237
p.H714Y	SIDM00602	Gastric Carcinoma	GDSC	CRHSLAIMP	DEG_APCC_DBOX_1	712:720	Mutation altering degron motif	0.6118
p.H714Y	ACH-000919	Gastric Cancer	CCLE	CRHSLAIMP	DEG_APCC_DBOX_1	712:720	Mutation altering degron motif	0.6118
p.H714Y	IM-95	stomach	COSMIC	CRHSLAIMP	DEG_APCC_DBOX_1	712:720	Mutation altering degron motif	0.6118
p.A717T	SIDM00007	Other Solid Cancers	GDSC	CRHSLAIMP	DEG_APCC_DBOX_1	712:720	Mutation altering degron motif	0.6028
p.A717T	ACH-001550	Skin Cancer	CCLE	CRHSLAIMP	DEG_APCC_DBOX_1	712:720	Mutation altering degron motif	0.6028
p.A717T	MCC13	skin	COSMIC	CRHSLAIMP	DEG_APCC_DBOX_1	712:720	Mutation altering degron motif	0.6028
p.S1490R	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VTSST	DEG_SPOP_SBC_1	1479:1483	Mutation blocking phosphorylation signal	0.5833
p.S1490R	ACH-002256	Leukemia	CCLE	VTSST	DEG_SPOP_SBC_1	1479:1483	Mutation blocking phosphorylation signal	0.5833
p.S1490R	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VTSST	DEG_SPOP_SBC_1	1479:1483	Mutation blocking phosphorylation signal	0.5833
p.I1361V	SIDM01112	Osteosarcoma	GDSC	DSGRGS	DEG_SCF_TRCP1_1	1359:1364	Mutation altering degron motif	0.7076
p.I1361V	SIDM01664	Prostate Carcinoma	GDSC	DSGRGS	DEG_SCF_TRCP1_1	1359:1364	Mutation altering degron motif	0.7076
p.H1534L	SIDM00482	Chronic Myelogenous Leukemia	GDSC	PPDY	ITCH	1529:1532	Mutation rewiring degron network	0.2778
p.N1374D	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DSGRGS	DEG_SCF_TRCP1_1	1359:1364	Mutation rewiring degron network	0.0556
p.N1374D	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DSGRGS	DEG_SCF_TRCP1_1	1359:1364	Mutation rewiring degron network	0.0556
p.S1523F	SIDM00003	Melanoma	GDSC	PPDY	ITCH	1529:1532	Mutation rewiring degron network	0.1667
p.S1523F	M14	skin	COSMIC	PPDY	ITCH	1529:1532	Mutation rewiring degron network	0.1667
p.V707L	SIDM01066	Melanoma	GDSC	CRHSLAIMP	DEG_APCC_DBOX_1	712:720	Mutation rewiring degron network	0.1944
p.V707L	ACH-000650	Skin Cancer	CCLE	CRHSLAIMP	DEG_APCC_DBOX_1	712:720	Mutation rewiring degron network	0.1944
p.V707L	IGR-37	skin	COSMIC	CRHSLAIMP	DEG_APCC_DBOX_1	712:720	Mutation rewiring degron network	0.1944
p.A1468P	SIDM00936	Bladder Carcinoma	GDSC	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation rewiring degron network	0.1667
p.A1468P	ACH-000142	Bladder Cancer	CCLE	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation rewiring degron network	0.1667
p.A1468P	CAL-29	urinary tract	COSMIC	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation rewiring degron network	0.1667
p.C1499S	SIDM00312	Plasma Cell Myeloma	GDSC	PPGY	ITCH	1508:1511	Mutation rewiring degron network	0.0833
p.S1541I	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PPDY	ITCH	1529:1532	Mutation rewiring degron network	0.0833
p.S1541I	PF-382	haematopoietic and lymphoid tissue	COSMIC	PPDY	ITCH	1529:1532	Mutation rewiring degron network	0.0833
p.S1398F	SIDM01617	Endometrial Carcinoma	GDSC	DPIAEVEPT	DEG_SIAH_1	1398:1406	Mutation altering degron motif	0.7982
p.S1398F	ACH-000994	Endometrial/Uterine Cancer	CCLE	DPIAEVEPT	DEG_SIAH_1	1398:1406	Mutation altering degron motif	0.7982
p.S1533I	ACH-000937	Leukemia	CCLE	PPDY	ITCH	1529:1532	Mutation blocking phosphorylation signal	0.75
p.S1533I	PF-382	haematopoietic and lymphoid tissue	COSMIC	PPDY	ITCH	1529:1532	Mutation blocking phosphorylation signal	0.75
p.S1515F	ACH-002159	Skin Cancer	CCLE	PPGY	ITCH	1508:1511	Mutation rewiring degron network	0.2222
p.S1515F	M14	skin	COSMIC	PPGY	ITCH	1508:1511	Mutation rewiring degron network	0.2222
p.G1499C	NCI-H1993	lung	COSMIC	PPGY	ITCH	1508:1511	Mutation rewiring degron network	0.0833
p.A1473P	CAL-29	urinary tract	COSMIC	VTSST	DEG_SPOP_SBC_1	1479:1483	Mutation rewiring degron network	0.1667
p.G1486C	NCI-H1993	lung	COSMIC	VTSST	DEG_SPOP_SBC_1	1479:1483	Mutation rewiring degron network	0.25
p.A1460P	CAL-29	urinary tract	COSMIC	LESTPAES	DEG_SCF_FBW7_1	1455:1462	Mutation altering degron motif	0.6392
p.S1482R	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VTSST	DEG_SPOP_SBC_1	1479:1483	Mutation altering degron motif	0.7427

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAPGEF6

UniProt ID: Q8TEU7

Entrez ID: 51735

Protein name: Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAPGEF6 in