DegronMD

Uniprot ID: Q8TEU7

Source protein: Rap guanine nucleotide exchange factor 6

Source gene: RAPGEF6

Class: DEG_SCF_FBW7_1

Location: 1455:1462

E3 ligase: FBXW7

DEGRON score: 0.9991

ASA_SCORE: 81.9125

COIL: 0.7421

CONS_SCORE: 0.3249

DSS_SCORE: 0.6013

HELIX: 0.0694

FCONS_SCORE: 1.0653

RIG_SCORE: 0.6788

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1450A	TCGA-2W-A8YY	CESC	TCGA	LESTPAES	DEG_SCF_FBW7_1	0.1944
p.T1450A	DO223732	CESC	ICGC	LESTPAES	DEG_SCF_FBW7_1	0.1944
p.S1446Y	TCGA-B5-A0JY	UCEC	TCGA	LESTPAES	DEG_SCF_FBW7_1	0.0833
p.S1446Y	DO43041	UCEC	ICGC	LESTPAES	DEG_SCF_FBW7_1	0.0833
p.S1445R	TCGA-VQ-A8PO	STAD	TCGA	LESTPAES	DEG_SCF_FBW7_1	0.0556
p.S1445R	DO51773	STAD	ICGC	LESTPAES	DEG_SCF_FBW7_1	0.0556
p.T1450M	TCGA-VQ-A91E	STAD	TCGA	LESTPAES	DEG_SCF_FBW7_1	0.1944
p.T1450M	DO51784	STAD	ICGC	LESTPAES	DEG_SCF_FBW7_1	0.1944
p.T1450M	SIDM01112	Osteosarcoma	GDSC	LESTPAES	DEG_SCF_FBW7_1	0.1944
p.T1450M	SIDM01088	Endometrial Carcinoma	GDSC	LESTPAES	DEG_SCF_FBW7_1	0.1944
p.T1450M	SIDM01664	Prostate Carcinoma	GDSC	LESTPAES	DEG_SCF_FBW7_1	0.1944
p.T1457P	TCGA-WS-AB45	COAD	TCGA	LESTPAES	DEG_SCF_FBW7_1	0.7031
p.T1457P	DO51734	COAD	ICGC	LESTPAES	DEG_SCF_FBW7_1	0.7031
p.Q1460R	DO229010	COCA	ICGC	LESTPAES	DEG_SCF_FBW7_1	0.7329
p.Q1460R	DO229013	COCA	ICGC	LESTPAES	DEG_SCF_FBW7_1	0.7329
p.Q1460R	DO229016	COCA	ICGC	LESTPAES	DEG_SCF_FBW7_1	0.7329
p.Q1460R	DO229003	COCA	ICGC	LESTPAES	DEG_SCF_FBW7_1	0.7329
p.Q1460R	DO229005	COCA	ICGC	LESTPAES	DEG_SCF_FBW7_1	0.7329
p.E1464D	DO233900	GACA	ICGC	LESTPAES	DEG_SCF_FBW7_1	0.2778
p.A1468P	SIDM00936	Bladder Carcinoma	GDSC	LESTPAES	DEG_SCF_FBW7_1	0.1667
p.A1468P	ACH-000142	Bladder Cancer	CCLE	LESTPAES	DEG_SCF_FBW7_1	0.1667
p.A1468P	CAL-29	urinary_tract	COSMIC	LESTPAES	DEG_SCF_FBW7_1	0.1667
p.A1460P	CAL-29	urinary_tract	COSMIC	LESTPAES	DEG_SCF_FBW7_1	0.6392

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEU7	Rap guanine nucleotide exchange factor 6	DEG_SCF_FBW7_1	1455:1462	LESTPAES	FBXW7	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons