DegronMD

Uniprot ID: Q8TEU7

Source protein: Rap guanine nucleotide exchange factor 6

Source gene: RAPGEF6

Class: DEG_APCC_DBOX_1

Location: 712:720

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9785

ASA_SCORE: 77.1889

COIL: 0.7159

CONS_SCORE: 0.3377

DSS_SCORE: 0.4321

HELIX: 0.1421

FCONS_SCORE: 0.8592

RIG_SCORE: 0.7619

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S705I	TCGA-78-7220	LUAD	TCGA	CRHSLAIMP	DEG_APCC_DBOX_1	0.5833
p.S705I	DO24409	LUAD	ICGC	CRHSLAIMP	DEG_APCC_DBOX_1	0.5833
p.H711N	DO229031	LICA	ICGC	CRHSLAIMP	DEG_APCC_DBOX_1	0.3056
p.T709K	DO229008	LICA	ICGC	CRHSLAIMP	DEG_APCC_DBOX_1	0.25
p.R713K	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	CRHSLAIMP	DEG_APCC_DBOX_1	0.7237
p.R713K	NCI-H1299	lung	COSMIC	CRHSLAIMP	DEG_APCC_DBOX_1	0.7237
p.H714Y	SIDM00602	Gastric Carcinoma	GDSC	CRHSLAIMP	DEG_APCC_DBOX_1	0.6118
p.H714Y	ACH-000919	Gastric Cancer	CCLE	CRHSLAIMP	DEG_APCC_DBOX_1	0.6118
p.H714Y	IM-95	stomach	COSMIC	CRHSLAIMP	DEG_APCC_DBOX_1	0.6118
p.A717T	SIDM00007	Other Solid Cancers	GDSC	CRHSLAIMP	DEG_APCC_DBOX_1	0.6028
p.A717T	ACH-001550	Skin Cancer	CCLE	CRHSLAIMP	DEG_APCC_DBOX_1	0.6028
p.A717T	MCC13	skin	COSMIC	CRHSLAIMP	DEG_APCC_DBOX_1	0.6028
p.V707L	SIDM01066	Melanoma	GDSC	CRHSLAIMP	DEG_APCC_DBOX_1	0.1944
p.V707L	ACH-000650	Skin Cancer	CCLE	CRHSLAIMP	DEG_APCC_DBOX_1	0.1944
p.V707L	IGR-37	skin	COSMIC	CRHSLAIMP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEU7	Rap guanine nucleotide exchange factor 6	DEG_APCC_DBOX_1	712:720	CRHSLAIMP	APC,CDC20,FZR1	0.9785	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons