DegronMD

Uniprot ID: Q8TEU7

Source protein: Rap guanine nucleotide exchange factor 6

Source gene: RAPGEF6

Class: DEG_SIAH_1

Location: 1398:1406

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9896

ASA_SCORE: 61.4333

COIL: 0.6808

CONS_SCORE: 0.3453

DSS_SCORE: 0.4872

HELIX: 0.0711

FCONS_SCORE: 1.1012

RIG_SCORE: 0.7199

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1400S	TCGA-94-A5I6	LUSC	TCGA	DPIAEVEPT	DEG_SIAH_1	0.7427
p.R1400S	DO219176	LUSC	ICGC	DPIAEVEPT	DEG_SIAH_1	0.7427
p.D1394V	TCGA-S9-A6WL	LGG	TCGA	DPIAEVEPT	DEG_SIAH_1	0.2222
p.D1394V	DO48616	LGG	ICGC	DPIAEVEPT	DEG_SIAH_1	0.2222
p.H1403N	DO228948	LICA	ICGC	DPIAEVEPT	DEG_SIAH_1	0.7423
p.S1398F	SIDM01617	Endometrial Carcinoma	GDSC	DPIAEVEPT	DEG_SIAH_1	0.7982
p.S1398F	ACH-000994	Endometrial/Uterine Cancer	CCLE	DPIAEVEPT	DEG_SIAH_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEU7	Rap guanine nucleotide exchange factor 6	DEG_SIAH_1	1398:1406	DPIAEVEPT	SIAH1,SIAH2,SIAH3	0.9896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons