DegronMD

Uniprot ID: Q8TEU7

Source protein: Rap guanine nucleotide exchange factor 6

Source gene: RAPGEF6

Class: DEG_SCF_TRCP1_1

Location: 1359:1364

E3 ligase: BTRC

DEGRON score: 0.9746

ASA_SCORE: 63.95

COIL: 0.7863

CONS_SCORE: 0.3867

DSS_SCORE: 0.3645

HELIX: 0.1147

FCONS_SCORE: 1.1387

RIG_SCORE: 0.6179

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1357Y	TCGA-BS-A0UF	UCEC	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.2778
p.S1357Y	DO41488	UCEC	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.2778
p.I1362S	TCGA-EY-A215	UCEC	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.7341
p.I1362S	DO42665	UCEC	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.7341
p.R1370C	TCGA-HC-7211	PRAD	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.1667
p.R1370C	DO36287	PRAD	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.1667
p.H1360Q	TCGA-PK-A5HB	ACC	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.7582
p.S1362N	DO222503	COCA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.7069
p.K1360T	DO222509	ESCA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.7306
p.S1369R	DO228944	LICA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.1944
p.A1363D	DO229045	LICA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.7793
p.G1361E	DO222395	MELA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.7199
p.S1349L	DO35442	PACA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.0556
p.K1350N	DO219774	UCEC	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.0833
p.K1360R	SIDM00845	Burkitt's Lymphoma	GDSC	DSGRGS	DEG_SCF_TRCP1_1	0.7237
p.K1357T	SIDM00845	Burkitt's Lymphoma	GDSC	DSGRGS	DEG_SCF_TRCP1_1	0.2778
p.I1361V	SIDM01112	Osteosarcoma	GDSC	DSGRGS	DEG_SCF_TRCP1_1	0.7076
p.I1361V	SIDM01664	Prostate Carcinoma	GDSC	DSGRGS	DEG_SCF_TRCP1_1	0.7076
p.N1374D	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DSGRGS	DEG_SCF_TRCP1_1	0.0556
p.N1374D	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	DSGRGS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16471	Prolactin receptor	DEG_SCF_TRCP1_1	348:353	DSGRGS	BTRC	0.9988	More...
Q8TEU7	Rap guanine nucleotide exchange factor 6	DEG_SCF_TRCP1_1	1359:1364	DSGRGS	BTRC	0.9746	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SCF_TRCP1_1	1243:1248	DSGRGS	BTRC	0.9965	More...
Q8N398	von Willebrand factor A domain-containing protein 5B2	DEG_SCF_TRCP1_1	1141:1146	DSGRGS	BTRC	0.7446	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons