DegronMD - P16471(PRLR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S356N	TCGA-3N-A9WD	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation blocking phosphorylation signal	0.6944
p.C354F	TCGA-AJ-A3IA	UCEC	TCGA	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.3056
p.R351W	TCGA-B5-A3FC	UCEC	TCGA	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation altering degron motif	0.7523
p.P340T	TCGA-DX-A1L0	SARC	TCGA	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.1111
p.L359F	TCGA-EB-A44P	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.1667
p.G350S	TCGA-EB-A6QY	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation altering degron motif	0.6993
p.S356R	TCGA-EE-A2MM	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation blocking phosphorylation signal	0.6944
p.M338I	TCGA-EE-A2MT	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.0556
p.M338I	TCGA-FR-A726	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.0556
p.P340L	TCGA-GN-A266	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.1111
p.P340S	TCGA-GN-A266	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.1111
p.G352E	TCGA-RP-A695	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation altering degron motif	0.6087
p.A345V	DO17492	KIRC	ICGC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.25
p.P355Q	DO228976	LICA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.2778
p.A353V	DO45465	LUSC	ICGC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation altering degron motif	0.6936
p.G354S	DO222562	MELA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.3056
p.D356Y	DO222632	MELA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation blocking phosphorylation signal	0.6944
p.A346T	DO46657	PAAD	ICGC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.2778
p.S360F	DO232761	PBCA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.1389
p.S360F	DO219878	SKCA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.1389
p.S360N	DO220246	SARC	ICGC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.1389
p.A347T	DO218874	SKCA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.3056
p.E339K	DO50291	SKCM	ICGC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation substituting flanking lysine	0.1944
p.L350F	DO229199	THCA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation altering degron motif	0.6981
p.R341W	DO41235	UCEC	ICGC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.1389
p.L340M	SIDM00781	Colorectal Carcinoma	GDSC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.1111
p.L340M	SNU-C2B	large intestine	COSMIC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.1111
p.K363N	SIDM00663	Melanoma	GDSC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation substituting flanking lysine	0.1667
p.K363N	ACH-000814	Skin Cancer	CCLE	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation substituting flanking lysine	0.1667
p.K363N	Hs939-T	skin	COSMIC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation substituting flanking lysine	0.1667
p.K357N	SIDM00429	B-Lymphoblastic Leukemia	GDSC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.2222
p.K357N	NALM-6	haematopoietic and lymphoid tissue	COSMIC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.2222
p.M338L	SIDM01412	Oral Cavity Carcinoma	GDSC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.0556
p.M338L	ACH-000762	Head and Neck Cancer	CCLE	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation rewiring degron network	0.0556
p.S349A	EVSA-T	breast	COSMIC	DSGRGS	DEG_SCF_TRCP1_1	348:353	Mutation altering degron motif	0.87

Kaplan plot for PRLR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRLR

UniProt ID: P16471

Entrez ID: 5618

Protein name: Prolactin receptor (PRL-R)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRLR in