DegronMD

Uniprot ID: P16471

Source protein: Prolactin receptor

Source gene: PRLR

Class: DEG_SCF_TRCP1_1

Location: 348:353

E3 ligase: BTRC

DEGRON score: 0.9988

ASA_SCORE: 62.2167

COIL: 0.8797

CONS_SCORE: 0.9521

DSS_SCORE: 0.6659

HELIX: 0.0588

FCONS_SCORE: 1.3067

RIG_SCORE: 0.5626

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S356N	TCGA-3N-A9WD	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.6944
p.C354F	TCGA-AJ-A3IA	UCEC	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.3056
p.R351W	TCGA-B5-A3FC	UCEC	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.7523
p.P340T	TCGA-DX-A1L0	SARC	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.1111
p.L359F	TCGA-EB-A44P	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.1667
p.G350S	TCGA-EB-A6QY	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.6993
p.S356R	TCGA-EE-A2MM	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.6944
p.M338I	TCGA-EE-A2MT	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.0556
p.M338I	TCGA-FR-A726	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.0556
p.P340L	TCGA-GN-A266	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.1111
p.P340S	TCGA-GN-A266	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.1111
p.G352E	TCGA-RP-A695	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	0.6087
p.A345V	DO17492	KIRC	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.25
p.P355Q	DO228976	LICA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.2778
p.A353V	DO45465	LUSC	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.6936
p.G354S	DO222562	MELA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.3056
p.D356Y	DO222632	MELA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.6944
p.A346T	DO46657	PAAD	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.2778
p.S360F	DO232761	PBCA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.1389
p.S360F	DO219878	SKCA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.1389
p.S360N	DO220246	SARC	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.1389
p.A347T	DO218874	SKCA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.3056
p.E339K	DO50291	SKCM	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.1944
p.L350F	DO229199	THCA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.6981
p.R341W	DO41235	UCEC	ICGC	DSGRGS	DEG_SCF_TRCP1_1	0.1389
p.L340M	SIDM00781	Colorectal Carcinoma	GDSC	DSGRGS	DEG_SCF_TRCP1_1	0.1111
p.L340M	SNU-C2B	large_intestine	COSMIC	DSGRGS	DEG_SCF_TRCP1_1	0.1111
p.K363N	SIDM00663	Melanoma	GDSC	DSGRGS	DEG_SCF_TRCP1_1	0.1667
p.K363N	ACH-000814	Skin Cancer	CCLE	DSGRGS	DEG_SCF_TRCP1_1	0.1667
p.K363N	Hs939-T	skin	COSMIC	DSGRGS	DEG_SCF_TRCP1_1	0.1667
p.K357N	SIDM00429	B-Lymphoblastic Leukemia	GDSC	DSGRGS	DEG_SCF_TRCP1_1	0.2222
p.K357N	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	DSGRGS	DEG_SCF_TRCP1_1	0.2222
p.M338L	SIDM01412	Oral Cavity Carcinoma	GDSC	DSGRGS	DEG_SCF_TRCP1_1	0.0556
p.M338L	ACH-000762	Head and Neck Cancer	CCLE	DSGRGS	DEG_SCF_TRCP1_1	0.0556
p.S349A	EVSA-T	breast	COSMIC	DSGRGS	DEG_SCF_TRCP1_1	0.87

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16471	Prolactin receptor	DEG_SCF_TRCP1_1	348:353	DSGRGS	BTRC	0.9988	More...
Q8TEU7	Rap guanine nucleotide exchange factor 6	DEG_SCF_TRCP1_1	1359:1364	DSGRGS	BTRC	0.9746	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SCF_TRCP1_1	1243:1248	DSGRGS	BTRC	0.9965	More...
Q8N398	von Willebrand factor A domain-containing protein 5B2	DEG_SCF_TRCP1_1	1141:1146	DSGRGS	BTRC	0.7446	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGRGS

Degron related mutations and impact score

Drug responses associated with PRLR mutations

All proteins holding degron of DSGRGS