DegronMD - Q9Y4G8(RAPGEF2)

FUNCTION: Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10608844, PubMed:10548487, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions. {ECO:0000269|PubMed:10548487, ECO:0000269|PubMed:10608844, ECO:0000269|PubMed:10608883, ECO:0000269|PubMed:10801446, ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11359771, ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:16272156, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:23800469}. View more >>

GO - Biological processes (BP): adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; blood vessel development [GO:0001568]; brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cAMP-mediated signaling [GO:0019933]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; cellular response to nerve growth factor stimulus [GO:1990090]; establishment of endothelial barrier [GO:0061028]; establishment of endothelial intestinal barrier [GO:0090557]; forebrain neuron development [GO:0021884]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; microvillus assembly [GO:0030033]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of melanin biosynthetic process [GO:0048022]; nerve growth factor signaling pathway [GO:0038180]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of dendritic cell apoptotic process [GO:2000670]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein binding [GO:0032092]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vasculogenesis [GO:2001214]; protein localization to plasma membrane [GO:0072659]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of cell junction assembly [GO:1901888]; regulation of synaptic plasticity [GO:0048167]; small GTPase mediated signal transduction [GO:0007264]; ventricular system development [GO:0021591] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1242S	TCGA-24-2295	OV	TCGA	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.3056
p.A1242S	DO32173	OV	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.3056
p.V1163L	TCGA-44-2656	LUAD	TCGA	VSLHDE	LIG_APCC_ABBA_1	1165:1170	Mutation rewiring degron network	0.2778
p.V1163L	DO26052	LUAD	ICGC	VSLHDE	LIG_APCC_ABBA_1	1165:1170	Mutation rewiring degron network	0.2778
p.C1252S	TCGA-44-A4SS	LUAD	TCGA	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.2222
p.C1252S	DO24227	LUAD	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.2222
p.A1390S	TCGA-46-3768	LUSC	TCGA	VASST	DEG_SPOP_SBC_1	1380:1384	Mutation rewiring degron network	0.1667
p.A1390S	DO26466	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	1380:1384	Mutation rewiring degron network	0.1667
p.S1244I	TCGA-55-A491	LUAD	TCGA	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation altering degron motif	0.8453
p.S1244I	DO25787	LUAD	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation altering degron motif	0.8453
p.G1245C	TCGA-55-A491	LUAD	TCGA	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation altering degron motif	0.76
p.G1245C	DO25787	LUAD	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation altering degron motif	0.76
p.R1346L	TCGA-73-4662	LUAD	TCGA	AESSS	DEG_SPOP_SBC_1	1356:1360	Mutation rewiring degron network	0.0556
p.R1346L	DO24790	LUAD	ICGC	AESSS	DEG_SPOP_SBC_1	1356:1360	Mutation rewiring degron network	0.0556
p.D1240H	TCGA-75-6214	LUAD	TCGA	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.25
p.D1240H	DO24830	LUAD	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.25
p.R1236C	TCGA-90-A4ED	LUSC	TCGA	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.1389
p.R1236C	TCGA-EE-A2MR	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.1389
p.R1236C	TCGA-FW-A3R5	SKCM	TCGA	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.1389
p.R1236C	TCGA-G4-6586	COAD	TCGA	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.1389
p.R1236C	DO9698	COAD	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.1389
p.R1236C	DO45482	LUSC	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.1389
p.R1236C	DO37819	SKCM	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.1389
p.R1236C	DO37406	SKCM	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.1389
p.R1236C	SIDM00487	Colorectal Carcinoma	GDSC	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.1389
p.R1236C	ACH-000963	Colon/Colorectal Cancer	CCLE	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.1389
p.R1236C	CCK-81	large intestine	COSMIC	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.1389
p.R1172H	TCGA-93-A4JQ	LUAD	TCGA	VSLHDE	LIG_APCC_ABBA_1	1165:1170	Mutation rewiring degron network	0.2778
p.R1172H	TCGA-A5-A0G2	UCEC	TCGA	VSLHDE	LIG_APCC_ABBA_1	1165:1170	Mutation rewiring degron network	0.2778
p.R1172H	DO51195	LUAD	ICGC	VSLHDE	LIG_APCC_ABBA_1	1165:1170	Mutation rewiring degron network	0.2778
p.R1172H	DO41235	UCEC	ICGC	VSLHDE	LIG_APCC_ABBA_1	1165:1170	Mutation rewiring degron network	0.2778
p.K521N	TCGA-95-7039	LUAD	TCGA	GRNKLKKIL	DEG_APCC_DBOX_1	529:537	Mutation substituting flanking lysine	0.2222
p.K521N	DO23907	LUAD	ICGC	GRNKLKKIL	DEG_APCC_DBOX_1	529:537	Mutation substituting flanking lysine	0.2222
p.A1379S	TCGA-A5-A0G2	UCEC	TCGA	VASST	DEG_SPOP_SBC_1	1380:1384	Mutation rewiring degron network	0.3056
p.A1379S	DO41235	UCEC	ICGC	VASST	DEG_SPOP_SBC_1	1380:1384	Mutation rewiring degron network	0.3056
p.A1379S	SIDM01387	Small Cell Lung Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	1380:1384	Mutation rewiring degron network	0.3056
p.A1379S	ACH-000921	Lung Cancer	CCLE	VASST	DEG_SPOP_SBC_1	1380:1384	Mutation rewiring degron network	0.3056
p.A1237T	TCGA-AA-3864	COAD	TCGA	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.1667
p.A1237T	DO8490	COAD	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.1667
p.A1237T	SIDM00216	Colorectal Carcinoma	GDSC	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.1667
p.A1237T	ACH-000989	Colon/Colorectal Cancer	CCLE	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.1667
p.A1237T	SNU-175	large intestine	COSMIC	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.1667
p.S56I	TCGA-AG-A002	READ	TCGA	DSGSSS	DEG_SCF_TRCP1_1	53:58	Mutation altering degron motif	0.623
p.D538N	TCGA-AG-A002	READ	TCGA	GRNKLKKIL	DEG_APCC_DBOX_1	529:537	Mutation rewiring degron network	0.3056
p.D538N	TCGA-EI-6917	READ	TCGA	GRNKLKKIL	DEG_APCC_DBOX_1	529:537	Mutation rewiring degron network	0.3056
p.D538N	DO36881	READ	ICGC	GRNKLKKIL	DEG_APCC_DBOX_1	529:537	Mutation rewiring degron network	0.3056
p.S1158L	TCGA-AG-A002	READ	TCGA	VSLHDE	LIG_APCC_ABBA_1	1165:1170	Mutation rewiring degron network	0.1389
p.S1158L	TCGA-AX-A06F	UCEC	TCGA	VSLHDE	LIG_APCC_ABBA_1	1165:1170	Mutation rewiring degron network	0.1389
p.S1158L	TCGA-AX-A0J0	UCEC	TCGA	VSLHDE	LIG_APCC_ABBA_1	1165:1170	Mutation rewiring degron network	0.1389
p.S1158L	DO41752	UCEC	ICGC	VSLHDE	LIG_APCC_ABBA_1	1165:1170	Mutation rewiring degron network	0.1389
p.S1158L	DO41133	UCEC	ICGC	VSLHDE	LIG_APCC_ABBA_1	1165:1170	Mutation rewiring degron network	0.1389
p.D1258A	TCGA-AX-A0J0	UCEC	TCGA	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.0556
p.D1258A	DO41133	UCEC	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.0556
p.R541L	TCGA-BF-A1PZ	SKCM	TCGA	GRNKLKKIL	DEG_APCC_DBOX_1	529:537	Mutation rewiring degron network	0.2222
p.R541L	DO50279	SKCM	ICGC	GRNKLKKIL	DEG_APCC_DBOX_1	529:537	Mutation rewiring degron network	0.2222
p.H1377L	TCGA-CJ-4901	KIRC	TCGA	VASST	DEG_SPOP_SBC_1	1380:1384	Mutation rewiring degron network	0.25
p.H1377L	DO16276	KIRC	ICGC	VASST	DEG_SPOP_SBC_1	1380:1384	Mutation rewiring degron network	0.25
p.H1377L	DO35549	PBCA	ICGC	VASST	DEG_SPOP_SBC_1	1380:1384	Mutation rewiring degron network	0.25
p.S543N	TCGA-D3-A8GJ	SKCM	TCGA	GRNKLKKIL	DEG_APCC_DBOX_1	529:537	Mutation rewiring degron network	0.1667
p.S543N	DO50285	SKCM	ICGC	GRNKLKKIL	DEG_APCC_DBOX_1	529:537	Mutation rewiring degron network	0.1667
p.G1348S	TCGA-D3-A8GM	SKCM	TCGA	AESSS	DEG_SPOP_SBC_1	1356:1360	Mutation rewiring degron network	0.1111
p.G1348S	DO50288	SKCM	ICGC	AESSS	DEG_SPOP_SBC_1	1356:1360	Mutation rewiring degron network	0.1111
p.G55A	TCGA-DD-A1EC	LIHC	TCGA	DSGSSS	DEG_SCF_TRCP1_1	53:58	Mutation altering degron motif	0.754
p.G55A	DO22982	LIHC	ICGC	DSGSSS	DEG_SCF_TRCP1_1	53:58	Mutation altering degron motif	0.754
p.D1427N	TCGA-EI-6917	READ	TCGA	PPDY	ITCH	1425:1428	Mutation altering degron motif	0.5821
p.D1427N	DO36881	READ	ICGC	PPDY	ITCH	1425:1428	Mutation altering degron motif	0.5821
p.S1353Y	TCGA-EX-A1H6	CESC	TCGA	AESSS	DEG_SPOP_SBC_1	1356:1360	Mutation rewiring degron network	0.25
p.S1353Y	DO44308	CESC	ICGC	AESSS	DEG_SPOP_SBC_1	1356:1360	Mutation rewiring degron network	0.25
p.P1415L	TCGA-FS-A1Z3	SKCM	TCGA	PPGY	ITCH	1403:1406	Mutation rewiring degron network	0.0833
p.P1415L	TCGA-FS-A1Z3	SKCM	TCGA	PPDY	ITCH	1425:1428	Mutation rewiring degron network	0.0556
p.P1415L	DO37635	SKCM	ICGC	PPGY	ITCH	1403:1406	Mutation rewiring degron network	0.0833
p.P1415L	DO37635	SKCM	ICGC	PPDY	ITCH	1425:1428	Mutation rewiring degron network	0.0556
p.P546Q	TCGA-FS-A1ZG	SKCM	TCGA	GRNKLKKIL	DEG_APCC_DBOX_1	529:537	Mutation rewiring degron network	0.0833
p.P546Q	DO37523	SKCM	ICGC	GRNKLKKIL	DEG_APCC_DBOX_1	529:537	Mutation rewiring degron network	0.0833
p.R1436Q	TCGA-HF-7132	STAD	TCGA	PPDY	ITCH	1425:1428	Mutation rewiring degron network	0.1111
p.R1436Q	TCGA-XK-AAIW	PRAD	TCGA	PPDY	ITCH	1425:1428	Mutation rewiring degron network	0.1111
p.R1436Q	DO222960	BTCA	ICGC	PPDY	ITCH	1425:1428	Mutation rewiring degron network	0.1111
p.R1436Q	DO51407	PRAD	ICGC	PPDY	ITCH	1425:1428	Mutation rewiring degron network	0.1111
p.R1436Q	DO38214	STAD	ICGC	PPDY	ITCH	1425:1428	Mutation rewiring degron network	0.1111
p.S57N	TCGA-L5-A8NM	ESCA	TCGA	DSGSSS	DEG_SCF_TRCP1_1	53:58	Mutation altering degron motif	0.5958
p.R1246S	TCGA-NH-A5IV	COAD	TCGA	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation altering degron motif	0.6316
p.R1246S	DO49095	COAD	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation altering degron motif	0.6316
p.T1369A	TCGA-OR-A5LK	ACC	TCGA	AESSS	DEG_SPOP_SBC_1	1356:1360	Mutation rewiring degron network	0.0833
p.K520N	TCGA-QG-A5Z1	COAD	TCGA	GRNKLKKIL	DEG_APCC_DBOX_1	529:537	Mutation substituting flanking lysine	0.1944
p.K520N	DO51731	COAD	ICGC	GRNKLKKIL	DEG_APCC_DBOX_1	529:537	Mutation substituting flanking lysine	0.1944
p.P1425L	TCGA-UF-A71A	HNSC	TCGA	PPDY	ITCH	1425:1428	Mutation altering degron motif	0.7582
p.P1425L	DO52106	HNSC	ICGC	PPDY	ITCH	1425:1428	Mutation altering degron motif	0.7582
p.P1373L	TCGA-W3-A825	SKCM	TCGA	VASST	DEG_SPOP_SBC_1	1380:1384	Mutation rewiring degron network	0.1389
p.P1373L	DO51272	SKCM	ICGC	VASST	DEG_SPOP_SBC_1	1380:1384	Mutation rewiring degron network	0.1389
p.G1405S	TCGA-WQ-AB4B	LIHC	TCGA	PPGY	ITCH	1403:1406	Mutation altering degron motif	0.5882
p.G1405S	DO52327	LIHC	ICGC	PPGY	ITCH	1403:1406	Mutation altering degron motif	0.5882
p.G1405S	DO42673	UCEC	ICGC	PPGY	ITCH	1403:1406	Mutation altering degron motif	0.5882
p.R530S	TCGA-XF-AAMG	BLCA	TCGA	GRNKLKKIL	DEG_APCC_DBOX_1	529:537	Mutation altering degron motif	0.7427
p.R530S	DO219049	BLCA	ICGC	GRNKLKKIL	DEG_APCC_DBOX_1	529:537	Mutation altering degron motif	0.7427
p.A1237V	DO230326	COCA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.1667
p.R541W	DO233854	GACA	ICGC	GRNKLKKIL	DEG_APCC_DBOX_1	529:537	Mutation rewiring degron network	0.2222
p.V1165F	DO228952	LICA	ICGC	VSLHDE	LIG_APCC_ABBA_1	1165:1170	Mutation altering degron motif	0.5957
p.V1155F	DO229026	LICA	ICGC	VSLHDE	LIG_APCC_ABBA_1	1165:1170	Mutation rewiring degron network	0.0556
p.G1394C	DO229036	LICA	ICGC	VASST	DEG_SPOP_SBC_1	1380:1384	Mutation rewiring degron network	0.0556
p.G1394C	DO229036	LICA	ICGC	PPGY	ITCH	1403:1406	Mutation rewiring degron network	0.0833
p.R1236L	DO229045	LICA	ICGC	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation rewiring degron network	0.1389
p.T1402P	DO50894	LICA	ICGC	PPGY	ITCH	1403:1406	Mutation rewiring degron network	0.3056
p.R1346W	DO218180	ORCA	ICGC	AESSS	DEG_SPOP_SBC_1	1356:1360	Mutation rewiring degron network	0.0556
p.P1421L	DO35083	PACA	ICGC	PPDY	ITCH	1425:1428	Mutation rewiring degron network	0.2222
p.F1414S	DO229227	THCA	ICGC	PPGY	ITCH	1403:1406	Mutation rewiring degron network	0.1111
p.G1405R	DO229232	THCA	ICGC	PPGY	ITCH	1403:1406	Mutation altering degron motif	0.6457
p.T1366M	SIDM02049	Pancreatic Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	1356:1360	Mutation rewiring degron network	0.1667
p.T1366M	SIDM00662	Melanoma	GDSC	AESSS	DEG_SPOP_SBC_1	1356:1360	Mutation rewiring degron network	0.1667
p.T1366M	SIDM00188	Kidney Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	1356:1360	Mutation rewiring degron network	0.1667
p.T1366M	SIDM01711	Non-Cancerous	GDSC	AESSS	DEG_SPOP_SBC_1	1356:1360	Mutation rewiring degron network	0.1667
p.T1366M	Hs940-T	skin	COSMIC	AESSS	DEG_SPOP_SBC_1	1356:1360	Mutation rewiring degron network	0.1667
p.S58C	SIDM02016	Colorectal Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	53:58	Mutation altering degron motif	0.8652
p.A65G	SIDM00074	Burkitt's Lymphoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	53:58	Mutation rewiring degron network	0.1389
p.A65G	BL-70	haematopoietic and lymphoid tissue	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	53:58	Mutation rewiring degron network	0.1389
p.S54F	SIDM00007	Other Solid Cancers	GDSC	DSGSSS	DEG_SCF_TRCP1_1	53:58	Mutation altering degron motif	0.7982
p.S54F	ACH-001550	Skin Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	53:58	Mutation altering degron motif	0.7982
p.S54F	MCC13	skin	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	53:58	Mutation altering degron motif	0.7982
p.V1430M	SIDM00329	Hodgkin's Lymphoma	GDSC	PPDY	ITCH	1425:1428	Mutation rewiring degron network	0.2778
p.V1430M	ACH-000806	Lymphoma	CCLE	PPDY	ITCH	1425:1428	Mutation rewiring degron network	0.2778
p.V1430M	L-540	haematopoietic and lymphoid tissue	COSMIC	PPDY	ITCH	1425:1428	Mutation rewiring degron network	0.2778
p.R1246C	SIDM00472	Ovarian Carcinoma	GDSC	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation altering degron motif	0.719
p.R1246C	ACH-001630	Ovarian Cancer	CCLE	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation altering degron motif	0.719
p.R1246C	PEO1	ovary	COSMIC	DSGRGS	DEG_SCF_TRCP1_1	1243:1248	Mutation altering degron motif	0.719
p.T1412A	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PPGY	ITCH	1403:1406	Mutation rewiring degron network	0.1667
p.T1412A	ACH-002059	Leukemia	CCLE	PPGY	ITCH	1403:1406	Mutation rewiring degron network	0.1667
p.R1347S	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	1356:1360	Mutation rewiring degron network	0.0833
p.R1347S	ACH-000917	Esophageal Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	1356:1360	Mutation rewiring degron network	0.0833
p.R1347S	TE-4	oesophagus	COSMIC	AESSS	DEG_SPOP_SBC_1	1356:1360	Mutation rewiring degron network	0.0833
p.A1381V	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	1380:1384	Mutation altering degron motif	0.5825
p.A1381V	NCI-H3122	lung	COSMIC	VASST	DEG_SPOP_SBC_1	1380:1384	Mutation altering degron motif	0.5825
p.I50V	SIDM01608	Endometrial Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	53:58	Mutation rewiring degron network	0.25
p.I50V	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	53:58	Mutation rewiring degron network	0.25
p.L1361P	SIDM01608	Endometrial Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	1356:1360	Mutation rewiring degron network	0.3056
p.L1361P	ACH-000990	Endometrial/Uterine Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	1356:1360	Mutation rewiring degron network	0.3056
p.H1168R	SIDM01617	Endometrial Carcinoma	GDSC	VSLHDE	LIG_APCC_ABBA_1	1165:1170	Mutation altering degron motif	0.8244
p.H1168R	ACH-000994	Endometrial/Uterine Cancer	CCLE	VSLHDE	LIG_APCC_ABBA_1	1165:1170	Mutation altering degron motif	0.8244
p.T1362R	ACH-000836	Head and Neck Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	1356:1360	Mutation rewiring degron network	0.2778
p.R1172G	ACH-001347	Head and Neck Cancer	CCLE	VSLHDE	LIG_APCC_ABBA_1	1165:1170	Mutation rewiring degron network	0.2778
p.P1178Q	LS-411N	large intestine	COSMIC	VSLHDE	LIG_APCC_ABBA_1	1165:1170	Mutation blocking phosphorylation signal	0.5556
p.Y1395C	KALS-1	central nervous system	COSMIC	PPGY	ITCH	1403:1406	Mutation rewiring degron network	0.1111
p.Y1395C	TE-11	oesophagus	COSMIC	PPGY	ITCH	1403:1406	Mutation rewiring degron network	0.1111
p.S1361C	SK-LU-1	lung	COSMIC	AESSS	DEG_SPOP_SBC_1	1356:1360	Mutation rewiring degron network	0.3056
p.A531T	NCI-H1155	lung	COSMIC	GRNKLKKIL	DEG_APCC_DBOX_1	529:537	Mutation altering degron motif	0.7139
p.S1405N	22RV1	prostate	COSMIC	PPGY	ITCH	1403:1406	Mutation altering degron motif	0.7069
p.R1426C	PEO1	ovary	COSMIC	PPDY	ITCH	1425:1428	Mutation altering degron motif	0.8301
p.S1381T	NCI-H23	lung	COSMIC	VASST	DEG_SPOP_SBC_1	1380:1384	Mutation altering degron motif	0.7116
p.N1165S	Hs766T	pancreas	COSMIC	VSLHDE	LIG_APCC_ABBA_1	1165:1170	Mutation altering degron motif	0.7069
p.R1416C	CCK-81	large intestine	COSMIC	PPGY	ITCH	1403:1406	Mutation rewiring degron network	0.0556
p.R1416C	CCK-81	large intestine	COSMIC	PPDY	ITCH	1425:1428	Mutation rewiring degron network	0.0833
p.A1417T	SNU-175	large intestine	COSMIC	PPDY	ITCH	1425:1428	Mutation rewiring degron network	0.1111
p.R1407S	TE-4	oesophagus	COSMIC	PPGY	ITCH	1403:1406	Mutation rewiring degron network	0.3056
p.S1389Y	LNCaP-Clone-FGC	prostate	COSMIC	VASST	DEG_SPOP_SBC_1	1380:1384	Mutation rewiring degron network	0.1944
p.T1426M	Hs940-T	skin	COSMIC	PPDY	ITCH	1425:1428	Mutation altering degron motif	0.7423

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAPGEF2

UniProt ID: Q9Y4G8

Entrez ID: 9693

Protein name: Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RAPGEF2 in