DegronMD

Uniprot ID: Q9Y4G8

Source protein: Rap guanine nucleotide exchange factor 2

Source gene: RAPGEF2

Class: DEG_APCC_DBOX_1

Location: 529:537

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5218

ASA_SCORE: 94.5889

COIL: 0.5271

CONS_SCORE: 0.3953

DSS_SCORE: 0.3694

HELIX: 0.4362

FCONS_SCORE: 1.0552

RIG_SCORE: 0.8124

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K521N	TCGA-95-7039	LUAD	TCGA	GRNKLKKIL	DEG_APCC_DBOX_1	0.2222
p.K521N	DO23907	LUAD	ICGC	GRNKLKKIL	DEG_APCC_DBOX_1	0.2222
p.D538N	TCGA-AG-A002	READ	TCGA	GRNKLKKIL	DEG_APCC_DBOX_1	0.3056
p.D538N	TCGA-EI-6917	READ	TCGA	GRNKLKKIL	DEG_APCC_DBOX_1	0.3056
p.D538N	DO36881	READ	ICGC	GRNKLKKIL	DEG_APCC_DBOX_1	0.3056
p.R541L	TCGA-BF-A1PZ	SKCM	TCGA	GRNKLKKIL	DEG_APCC_DBOX_1	0.2222
p.R541L	DO50279	SKCM	ICGC	GRNKLKKIL	DEG_APCC_DBOX_1	0.2222
p.S543N	TCGA-D3-A8GJ	SKCM	TCGA	GRNKLKKIL	DEG_APCC_DBOX_1	0.1667
p.S543N	DO50285	SKCM	ICGC	GRNKLKKIL	DEG_APCC_DBOX_1	0.1667
p.P546Q	TCGA-FS-A1ZG	SKCM	TCGA	GRNKLKKIL	DEG_APCC_DBOX_1	0.0833
p.P546Q	DO37523	SKCM	ICGC	GRNKLKKIL	DEG_APCC_DBOX_1	0.0833
p.K520N	TCGA-QG-A5Z1	COAD	TCGA	GRNKLKKIL	DEG_APCC_DBOX_1	0.1944
p.K520N	DO51731	COAD	ICGC	GRNKLKKIL	DEG_APCC_DBOX_1	0.1944
p.R530S	TCGA-XF-AAMG	BLCA	TCGA	GRNKLKKIL	DEG_APCC_DBOX_1	0.7427
p.R530S	DO219049	BLCA	ICGC	GRNKLKKIL	DEG_APCC_DBOX_1	0.7427
p.R541W	DO233854	GACA	ICGC	GRNKLKKIL	DEG_APCC_DBOX_1	0.2222
p.A531T	NCI-H1155	lung	COSMIC	GRNKLKKIL	DEG_APCC_DBOX_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_APCC_DBOX_1	529:537	GRNKLKKIL	APC,CDC20,FZR1	0.5218	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons