DegronMD

Uniprot ID: Q9Y4G8

Source protein: Rap guanine nucleotide exchange factor 2

Source gene: RAPGEF2

Class: DEG_SCF_TRCP1_1

Location: 53:58

E3 ligase: BTRC

DEGRON score: 0.9394

ASA_SCORE: 71.3667

COIL: 0.8568

CONS_SCORE: 0.4144

DSS_SCORE: 0.4638

HELIX: 0.0697

FCONS_SCORE: 1.1319

RIG_SCORE: 0.5886

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S56I	TCGA-AG-A002	READ	TCGA	DSGSSS	DEG_SCF_TRCP1_1	0.623
p.G55A	TCGA-DD-A1EC	LIHC	TCGA	DSGSSS	DEG_SCF_TRCP1_1	0.754
p.G55A	DO22982	LIHC	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.754
p.S57N	TCGA-L5-A8NM	ESCA	TCGA	DSGSSS	DEG_SCF_TRCP1_1	0.5958
p.S58C	SIDM02016	Colorectal Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.8652
p.A65G	SIDM00074	Burkitt's Lymphoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.1389
p.A65G	BL-70	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	0.1389
p.S54F	SIDM00007	Other Solid Cancers	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.7982
p.S54F	ACH-001550	Skin Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	0.7982
p.S54F	MCC13	skin	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	0.7982
p.I50V	SIDM01608	Endometrial Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.25
p.I50V	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13428	Treacle protein	DEG_SCF_TRCP1_1	931:936	DSGSSS	BTRC	0.9956	More...
Q8IYG6	Leucine-rich repeat-containing protein 56	DEG_SCF_TRCP1_1	460:465	DSGSSS	BTRC	0.9835	More...
Q96S38	Ribosomal protein S6 kinase delta-1	DEG_SCF_TRCP1_1	499:504	DSGSSS	BTRC	0.9876	More...
Q9C0H9	SRC kinase signaling inhibitor 1	DEG_SCF_TRCP1_1	512:517	DSGSSS	BTRC	0.9672	More...
Q9H7S9	Zinc finger protein 703	DEG_SCF_TRCP1_1	169:174	DSGSSS	BTRC	0.9995	More...
Q9NQ76	Matrix extracellular phosphoglycoprotein	DEG_SCF_TRCP1_1	515:520	DSGSSS	BTRC	0.9943	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SCF_TRCP1_1	53:58	DSGSSS	BTRC	0.9394	More...
Q9C0H5	Rho GTPase-activating protein 39	DEG_SCF_TRCP1_1	168:173	DSGSSS	BTRC	0.9988	More...
Q86VQ1	Glucocorticoid-induced transcript 1 protein	DEG_SCF_TRCP1_1	393:398	DSGSSS	BTRC	0.9577	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons